Reposted by Marteinn Snæbjörnsson
RESEARCH | MT Snaebjornsson, @almutschulze.bsky.social et al. @dkfz.bsky.social
The authors explore a selective vulnerability in #cancer elicited by targeting AldolaseA, which causes #EnergyImbalance and prevents further #metabolic adaptations
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Targeting aldolase A in hepatocellular carcinoma leads to imbalanced glycolysis and energy stress due to uncontrolled FBP accumulation - Nature Metabolism
Snaebjornsson et al. explore a selective vulnerability in cancer elicited by targeting aldolase A, which causes energy imbalance and prevents further metabolic adaptations.
