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Dr. Mark A. Hix

@markahix.bsky.social
159 followers 226 following 237 posts

PhD theoretical chemist for biomolecules, protein engineering, QM/MM, excited states, automation | he/him/his | Opinions my own.

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Dr. Mark A. Hix @markahix.bsky.social · 7h
My student loan service company emailing me every other week to thank me for my payment like it's something I'm doing willingly and with any kind of positive feelings about it is beginning to grate on my nerves. I've already paid more than the original principal, and I've got 10 years to go. Jerks.
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Dr. Mark A. Hix @markahix.bsky.social · 10h
I'm finding myself constantly entertained by LinkedIn posts from AI hype accounts who include things like "I used a 2000-line prompt to achieve X" and my first thought is "I can do that with like 20 lines of code, though." AI cannot and will not replace actual innovation and real experience.
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Reposted by Dr. Mark A. Hix
Brendel @brendelbored.bsky.social · 05/10/2026
Professor Frink saying this
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Dr. Mark A. Hix @markahix.bsky.social · 01/10/2026
I keep seeing "uplifting" headlines like "California Law bans companies from using AI to monitor employee emotional states" and I'm beyond horrified that there needed to be a *law* against that, rather than absolutely any modicum of basic human decency being enough.
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Dr. Mark A. Hix @markahix.bsky.social · 30/09/2026
Public flogging of politicians who break the law might be a solid start. "You want to wield this kind of power? It comes with these kinds of consequences."
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Dr. Mark A. Hix @markahix.bsky.social · 23/09/2026
News: "<Service> free for <group>" Internet: "<Service> should be free for EVERYONE!" Improvements aren't usually all-or-nothing events. Getting <Service> free for <group> makes it easier to increase <group> towards EVERYONE, because it's harder to justify objections to the increment. like M4A.
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Dr. Mark A. Hix @markahix.bsky.social · 02/09/2026
"Non-profit" seems to be used more and more to mislead people. Non-profit just means "nothing left over after expenses", it doesn't really mean that the expenses aren't absurd salaries in lieu of actually helping people who need it.
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Dr. Mark A. Hix @markahix.bsky.social · 02/09/2026
I want, more than anything, a serious academic journal that is specifically focused on failures. "We had a goal. We had a hypothesis. We tried 84 different methods that didn't work. We ran out of funding. We had to stop the project." We gotta know about those 84 method so we don't repeat them!
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Dr. Mark A. Hix @markahix.bsky.social · 29/08/2026
Pretty sure we fought a whole war to not give a shit what y'all think. Just like a hundred other countries around the world who celebrate an Independence Day. Get over yourself, you're not the arbiter of language.
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Reposted by Dr. Mark A. Hix
👻 Jack Djinn Wail 🧞 @jacktindale.bsky.social · 28/08/2026
Minor point but I really hate this performative “y’all” people do to try and appear more folksy. I don’t type in a Yorkshire accent and I did people would rightly tell me to shut up.
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Abdul El-Sayed @abdulelsayed.bsky.social · 23/08/2026
We're being told that if we sacrifice the rights of some people, then the rest of us get to keep our rights. We all know that's some BS.
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Dr. Mark A. Hix @markahix.bsky.social · 11/08/2026
Whatever publishing company executive had the idea to advertise other books on the backs of toddler books is two things: 1. An absolutely brilliant businessperson and marketing genius. 2. 100% the villain of our tale. We have purchased so many toddler books. My bookshelf has been overrun...
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michael veale @michae.lv · 07/08/2026
Cloudflare (>20% of all domains) has started automatically implementing DSM Dir art 4 rights reservation (ie copyright/TDM objection to scraping) for all sites that do not have a robots.txt file. They also adding purpose fields to robots.txt unilaterally. developers.cloudflare.com/bots/additio...
# As a condition of accessing this website, you agree to abide by the following
# content signals:

# (a)  If a Content-Signal = yes, you may collect content for the corresponding
#      use.
# (b)  If a Content-Signal = no, you may not collect content for the
#      corresponding use.
# (c)  If the website operator does not include a Content-Signal for a
#      corresponding use, the website operator neither grants nor restricts
#      permission via Content-Signal with respect to the corresponding use.

# The content signals and their meanings are:

# search:   building a search index and providing search results (e.g., returning
#           hyperlinks and short excerpts from your website's contents). Search does not
#           include providing AI-generated search summaries.
# ai-input: inputting content into one or more AI models (e.g., retrieval
#           augmented generation, grounding, or other real-time taking of content for
#           generative AI search answers).
# ai-train: training or fine-tuning AI models.
# use:      how AI systems may consume the content (immediate, reference, or full).

# ANY RESTRICTIONS EXPRESSED VIA CONTENT SIGNALS ARE EXPRESS RESERVATIONS OF
# RIGHTS UNDER ARTICLE 4 OF THE EUROPEAN UNION DIRECTIVE 2019/790 ON COPYRIGHT
# AND RELATED RIGHTS IN THE DIGITAL SINGLE MARKET.

# BEGIN Cloudflare Managed content
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Dr. Mark A. Hix @markahix.bsky.social · 07/08/2026
Anyone seeking asylum should... *checks notes* sleep on a rock and eat with their hands, got it.
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Dr. Mark A. Hix @markahix.bsky.social · 05/08/2026
Dear LinkedIn, No matter how desperately you may plead with me, I will never - and I must reiterate this again - NEVER download and install a "LinkedIn App" to my computer. I don't care if you promise to immediately hand me a 7-figure job. Take that garbage elsewhere.
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Brooke Harrington @ebharrington.bsky.social · 03/08/2026
"don't make enough money" is a fig leaf All those degree programs--social work, art, etc.--have disproportionately female student bodies. This is designed to make it harder for women to attend college--college education being a key factor in women's autonomy from men & left-leaning voting pattern.
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@wsuchemistry.bsky.social @waynestatechem.bsky.social · 03/08/2026
Congrats to Dr. Matt Allen, for being named a fellow of the @RSC.org, one of the highest distinctions awarded by the world’s oldest chemical society. #wsuchemistry #chemsky clas.wayne.edu/chemistry/ne...
clas.wayne.edu
WSU chemistry chair and AVP for research and innovation named fellow of Royal Society of Chemistry
Wayne State chemistry chair Matthew Allen named a Fellow of the Royal Society of Chemistry, one of the field's most prestigious senior honors.
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Dr. Mark A. Hix @markahix.bsky.social · 17/07/2026
One of the frequent ads I see during my doomscrolling is for an enclosed garden bed/house structure. And all I can see is the amount of fully untreated and improper wood they're using. It's so unready to be used the way they have it, it's sucking moisture out of the dirt. It's gonna rot so fast.
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James Talarico @jamestalarico.bsky.social · 07/07/2026
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Dr. Mark A. Hix @markahix.bsky.social · 02/07/2026
Socialist policies are only "bad for business" if your business is hoarding as much money as you can while intentionally creating suffering in as many people as possible. Then, yeah, sure.
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Dr. Mark A. Hix @markahix.bsky.social · 02/07/2026
I am ride-or-die for tardigrades. Little eldritch horrors just floating around in the void of space, unbothered by any of the quaint concerns like "Radiation" or "Sustenance of any kind". Little monsters from beyond the veil, I love them.
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Dr. Mark A. Hix @markahix.bsky.social · 30/06/2026
"... at birth, owe allegiance solely to this country." Aww, look at the cute little baby born only hours ago, can't even really open its eyes... Here's your rifle, baby, you owe this country your allegiance! To war with you! Alito is a trash bag of a human and this dissent is unconcealed bigotry.
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Dr. Mark A. Hix @markahix.bsky.social · 23/06/2026
Electricity Usage this month vs. last year: +6%. Electricity Bill this month vs. last year: +22% DTE energy is the absolute worst. They're presenting my bill like somehow I'M the problem and not the fact that they're asking for another $500M rate increase this year.
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Dr. Mark A. Hix @markahix.bsky.social · 20/06/2026
You will also spend the GDP of a small country on berries. There will not be enough, regardless of the quantity consumed.
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Sarah Shay @sarahshay.com · 14/06/2026
My biggest editing client has officially replaced me with an LLM, meaning I am now functionally unemployed. If any of you need a proofreader or copy editor and value having a human being who can tell right from wrong doing the job, let me know?
sarahshay.com
Copy Editing and Proofreading – Sarah Shay
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Dr. Mark A. Hix @markahix.bsky.social · 13/06/2026
If money is the lifeblood of an economy, a trillionaire is the blood clot about to hit the brain.
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@wsuchemistry.bsky.social @waynestatechem.bsky.social · 11/06/2026
Solomon Effah, of the Walker Lab, has been recognized by Schrödinger, as a winner of the Molecules & Models Virtual Science Fair, an event that builds connections between researchers across institutions and career stages. Congratulations, all! #wsuchemistry #compchem #chemsky
Solomon Effah and other winners of the Molecules & Models Virtual Science FaiPhoto of Solomon Effah and the title of his winning presentation: “Controlling Fluorescence in DNA Probes: Structural Design of Perylene-Modified Nucleic Acids for Enhanced Imaging”
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@wsuchemistry.bsky.social @waynestatechem.bsky.social · 10/06/2026
Check out the Walker Lab’s new paper: “Librarian of Alexandria: A Modular Chemical Data Extraction Pipeline to Compare LLM Performance.” #wsuchemistry #compchem #ChemSky #machinelearning pubs.acs.org/doi/10.1021/...
pubs.acs.org
Librarian of Alexandria: A Modular Chemical Data Extraction Pipeline to Compare LLM Performance
Dataset creation is a critical component of predictive machine learning technology. In the field of chemistry, large experimental datasets are scarce, especially for niche chemical properties and topi...
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Dr. Mark A. Hix @markahix.bsky.social · 02/06/2026
Saw a "parenting hack" that says you should tape the bubble container to a chair so the kids can't spill it and my first thought was "have you literally ever seen a toddler near a chair?" Toddlers treat upright chairs as an affront to nature that must be corrected immediately.
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Dr. Mark A. Hix @markahix.bsky.social · 25/05/2026
My monthly electric bill shows a year-over-year comparison for the month. Over last year, my usage increased by 19%. My bill increased by 36%. The electricity was not 17% better, my appliances did not run 17% faster or get my clothes 17% cleaner. The lights were not 17% brighter. Such a scam.
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Sarah McAnulty, Ph.D. @sarahmackattack.bsky.social · 15/05/2026
Can I sell enough plants that support Philly bugs to fund a mural that educates people about Philly's bugs??? Probably not! but like! Idk! Weirder things have happened!
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Dr. Mark A. Hix @markahix.bsky.social · 10/05/2026
With every jarring, blaring ad that interrupts my relaxing 10-hour nature video stream, I become more radicalized.
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Kevin Fox @michigrim.bsky.social · 30/04/2026
A captcha that is a reference to the opening scene of Master and Commander
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Alice R. Walker @arwalker.bsky.social · 29/04/2026
One tenure for me, thanks ✨ From the bottom of my heart, thank you to my amazing students, colleagues, mentors, collaborators and friends. Science is a group effort and even when it’s hard I love being in it with all of you. #compchem #chemsky
Letter of tenure notification
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Dr. Mark A. Hix @markahix.bsky.social · 21/04/2026
Dear Academic and Scientific Publishers, If you're going to provide a template that we're expected to use, please make sure it's the template you want us to use and that you don't then make a bunch of extra demands for things the template doesn't currently support. Sincerely, Everyone
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Alice R. Walker @arwalker.bsky.social · 15/04/2026
So grateful for this award, and for the chance to present our group's research at ACS in the Fall! #compchem #chemsky
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Dr. Mark A. Hix @markahix.bsky.social · 13/04/2026
I'm curious if other job-seekers are seeing this pattern. I see a job posting on LinkedIn from Company A, but in the text of the posting, it opens with "Company B is committed to ..." I've seen this pattern with multiple Companies A referring to multiple Companies B. Is it just crappy recruiters?
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Dr. Mark A. Hix @markahix.bsky.social · 07/04/2026
I'd be mad, but this is honestly just par for the course in this age of technocratic nonsense. I'm not surprised. I'm not even disappointed, because I never expected anything better from any of these companies.
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Raider @iwillnotbesilenced.bsky.social · 23/03/2026
If you’re traveling and spot ICE at the airport, start snapping photos. They aren't allowed to wear masks inside the terminal, which gives us a rare, massive opportunity for identification. Don’t miss the shot
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Jeri Ryan (official account) @jerilryan.bsky.social · 23/03/2026
Caption: Crew, it’s time for a sit-down to organize and exercise our rights. This Saturday. No Kings. Find a No Kings near you at NoKings.org. We can’t sit this one out. @rayzzo.bsky.social @1acommittee.bsky.social @50501movement.bsky.social
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Alice R. Walker @arwalker.bsky.social · 17/03/2026
Check out our new cover art, made by the talented @markahix.bsky.social ! It highlights orbital mixing of a low barrier hydrogen bond that spans the dimer interface of YajL. Small changes tune LBHB character in homologue DJ1. With a point mutation it appears! pubs.acs.org/toc/bichaw/6...
A YajL protein dimer is shown in green and yellow protein surfaces with an interfacial aspartate/glutamate low-barrier hydrogen bond displayed with mixed-valence orbitals, calculated using quantum mechanics/molecular mechanics for each amino acid.  The low-barrier hydrogen bond in the center is highlighted.
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Dr. Mark A. Hix @markahix.bsky.social · 12/03/2026
I love how obvious all the predatory (MDPI) journal emails are. "We can tell by your publication record that you're an expert in the field of Electroplating Potato Beetles with Deep Sea Shrimp Eyeballs" Buddy, I've never even conceived of those words in that order before.
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Dr. Mark A. Hix @markahix.bsky.social · 02/03/2026
I have a tendency to get into an analysis groove where I will remain *intensely* focused on it for so long I suddenly feel my tongue cracking from dry mouth, and then I look like Charlie Day.
media.tenor.com
a man in a blue shirt and tie is pointing at a bulletin board with a lot of papers on it .
ALT: a man in a blue shirt and tie is pointing at a bulletin board with a lot of papers on it .
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Dr. Mark A. Hix @markahix.bsky.social · 23/02/2026
It is the grapefruit, for no other reason than it tastes like absolute garbage and huge swaths of population can't eat it without medical problems arising. The Grapefruit is God's Mistake.
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Dr. Mark A. Hix @markahix.bsky.social · 12/02/2026
"If all the names in the Epstein Files are released then our entire system would collapse." so you're saying the system needs to be obliterated.
media.tenor.com
a man is holding a microphone and making a funny face .
ALT: a man is holding a microphone and making a funny face .
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LorennaCleary.bsky.social @lorennacleary.bsky.social · 12/02/2026
SAVE Act: Asks for naturalization papers which US birth citizens do not have. Or REAL ID which requires your last name match that of your birth certificate, which disqualifies married women who are US citizens. Or passport which poor rural Americans usually don’t have. SAVE Act is anti American
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Dr. Mark A. Hix @markahix.bsky.social · 05/02/2026
This monologue delivered by this man gives me chills, as it should every person who hears it.
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Dr. Mark A. Hix @markahix.bsky.social · 04/02/2026
If I ever found out a colleague or collaborator was doing this, I think I'd just ... explode. My blood pressure would literally pop my brain like a balloon.
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