iiinova — where your digital self keeps evolving

Marie Will, MD, PhD @marie-will.bsky.social · 08/02/2025

But… hear me out… how much of this damage was just from the last few weeks of excessive grinding for all of us?

Marie Will, MD, PhD @marie-will.bsky.social · 06/02/2025

Today, we are one step closer to the next pandemic, just as the people in charge proudly proclaim that they don’t believe in either vaccines or infectious diseases. Without public health communication, we are flying blind. If I haven’t been posting, it’s because I am literally at a loss for words.

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Marie Will, MD, PhD @marie-will.bsky.social · 22/01/2025

So much is happening so fast that it’s easy to be on outrage overload. But as you pick your battles (and there are so many!), also remember to take care of yourself. For me, I made my own marshmallow so I could eat my feelings in fluffy, cloud-like, sugar-pillow form. #medfoodsky #doctorswhocook

Picture of white, fluffy, homemade marshmallow on a plate.

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Marie Will, MD, PhD @marie-will.bsky.social · 22/01/2025

If COVID-19 taught us anything, it’s that diseases don’t respect borders. We are all in this together. Withdrawing from a global public health organization - while under new pandemic threats - will not only limit our own access to data/resources but also weaken the global response. 🤦🏻‍♀️

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Marie Will, MD, PhD @marie-will.bsky.social · 17/01/2025

Circulating tumor DNA (ctDNA) is branded as a “liquid biopsy” - a simple blood test that can detect cancer, bypassing invasive biopsy procedures. Problem is it lacks sensitivity in the early stage. Here, a new ultra-sensitive ctDNA assay that improves early detection and enables outcome prediction.

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Marie Will, MD, PhD @marie-will.bsky.social · 17/01/2025

I would still say that’s making them! Knowing the right shortcuts is a sign of expertise!

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Marie Will, MD, PhD @marie-will.bsky.social · 13/01/2025

Of all the things I have ever made, my nyc-native kids were most impressed by this one 🤣

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Marie Will, MD, PhD @marie-will.bsky.social · 13/01/2025

6 months after leaving NYC, I have arrived at the stage of making my own bagels at home. If that catches your attention, please consider donating to the real chefs at World Central Kitchen, who are helping with the California fires, here: wck.org/relief/calif... #doctorswhocook #ChefsForCalifornia

A stack of everything bagels on a wooden cutting board.

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Marie Will, MD, PhD @marie-will.bsky.social · 11/01/2025

Many people who undergo genetic testing for cancer risks will find themselves with a “variant of uncertain significance.” Even when the risk is unclear (as the term implies), seeing a gene like BRCA2 on your report is understandably unnerving. Functional studies like this are so needed for clarity.

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Marie Will, MD, PhD @marie-will.bsky.social · 11/01/2025

So sorry to hear this - hope you all stay safe!

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Marie Will, MD, PhD @marie-will.bsky.social · 07/01/2025

If you, like me, are getting that deja vu feeling reading this news, try not to panic (yet). Instead, tune into the influenza experts. @colincarlson.bsky.social has kindly made a starter pack of people who have had long term research interests in influenza, including H5N1, here: go.bsky.app/L1vwJPS

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Marie Will, MD, PhD @marie-will.bsky.social · 07/01/2025

I promise it tastes almost as good as it looks! 😂

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Marie Will, MD, PhD @marie-will.bsky.social · 07/01/2025

So this may be a good time to admit that I have a sourdough starter? 😅😂

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Marie Will, MD, PhD @marie-will.bsky.social · 06/01/2025

And you have a super super cool display name!

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Marie Will, MD, PhD @marie-will.bsky.social · 06/01/2025

I too am obsessed with my cat. She’s like a solid part of my personality 🤣

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Marie Will, MD, PhD @marie-will.bsky.social · 06/01/2025

@thanhneville.bsky.social thank you! I was inspired by you and all the deliciousness you always serve up. I thought I was supposed to stick with medicine content, but then you made me feel like we can be a WHOLE person with all our dimensions!

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Marie Will, MD, PhD @marie-will.bsky.social · 04/01/2025

I feel like I have been on Bluesky long enough to confess to my obsession with cats, specifically this cat, who is constantly claiming all my chairs. Say hello to Thea, the queen cat. Happy New Year, Bluesky. May we all be such fierce defenders of our territories. We are gonna need it this year.

Photo of a grey and white long hair cat sitting on a winter-theme blanket on a recliner chair.

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Marie Will, MD, PhD @marie-will.bsky.social · 04/01/2025

Back from holidays, and I am still thinking about this discovery of ALAS1 as a global repressor of miRNA and its potential to improve siRNA therapy. RNA-targeting drugs (including for cancer) has always held huge promise but sluggish progress. These mechanistic studies are crucial for improvement.

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Marie Will, MD, PhD @marie-will.bsky.social · 28/12/2024

I feel pretty good about my obsession with Costco today, so I will share an oncologist’s secret: I buy my sunscreens from them so I always have enough of it to slather all over myself and my family in thick, protective layers. Cancer prevention aside, it really helps with the forever-young look.

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Marie Will, MD, PhD @marie-will.bsky.social · 26/12/2024

It did help occupy them for a few hours - a necessity when school is out 😂.

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Marie Will, MD, PhD @marie-will.bsky.social · 25/12/2024

I made a Yule Log cake but let my kids help decorate… and now it has not just flowers and mushrooms, but also black ants and insects because “they are important parts of fallen logs!” 🤦🏻‍♀️ Merry Christmas, Bluesky. May we all be such staunch defenders of the ecosystem. #medfoodsky, #doctorswhocook

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Marie Will, MD, PhD @marie-will.bsky.social · 23/12/2024

Will need a lot of tips for teenage years!

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Marie Will, MD, PhD @marie-will.bsky.social · 22/12/2024

Asked my 9yo why his room was a disastrous mess. Him, straight faced: “Welcome to the new America, Mama. Everything is a mess - it’s not my room. Are you sure this is your priority thing to tackle right now?” Is sarcasm how teenage years begin?

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Marie Will, MD, PhD @marie-will.bsky.social · 21/12/2024

I remember those days. The last few miles are always the hardest. Keep going, AND give yourself a break, you are almost there!

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Marie Will, MD, PhD @marie-will.bsky.social · 21/12/2024

To all the grad students and postdocs spending their weekends studying YFP (Your Favorite Protein) and mulling over scientific problems about which nobody else gives a damn, you are doing important work. Progress is not often a straight line, but knowledge is always a permanent gain.

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Marie Will, MD, PhD @marie-will.bsky.social · 19/12/2024

Thank you - I love your username and page!

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Marie Will, MD, PhD @marie-will.bsky.social · 19/12/2024

Thank you! This feed for MedFoodSky looks amazing!!

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Marie Will, MD, PhD @marie-will.bsky.social · 18/12/2024

Inspired by @thanhneville.bsky.social, I will post the apple frangipane tart (with almond paste) that I made for a recent holiday party. Arguably the wrong season for apple tarts, but we had extra apples! #DoctorsWhoCook or should I say #DoctorsWhoBake

An apple-almond tart with apples arranged in rosette pattern.

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Marie Will, MD, PhD @marie-will.bsky.social · 18/12/2024

We don’t often see numbers like 100% in oncology. That sort of response is exciting not just because it is practice-changing, but also because it offers a rare & powerful clue about the nature of the disease itself. Excited for the basic scientific studies to come - bedside to bench and back again.

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Marie Will, MD, PhD @marie-will.bsky.social · 15/12/2024

Absolutely agree - those are the most powerful tools we could give our kids.

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Marie Will, MD, PhD @marie-will.bsky.social · 14/12/2024

That’s such important work - please teach us all and thanks for what you do! I must admit that many of us in science and medicine, including me, have shied away from social media. But now, more than ever, science needs a voice in public discourse, and we can’t afford our own silence in this space.

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Marie Will, MD, PhD @marie-will.bsky.social · 14/12/2024

To me, AI just a technology - and like all technologies, it is the way we design, use, implement, and interpret it that will matter. BMJ, JAMA, Cancer Cell, Cancer Discovery, and many other journals all have recent articles on the use of AI in oncology if you would like to check those out!

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Marie Will, MD, PhD @marie-will.bsky.social · 14/12/2024

More and more, oncologists will need to find innovative ways to incorporate AI into both research and patient care. Here, Pedram Razavi from @mskcancercenter.bsky.social showed us a powerful example of how such technology can be utilized to predict therapy responders in breast cancer. #SABCS24

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Marie Will, MD, PhD @marie-will.bsky.social · 14/12/2024

Congratulations to @caiy0219.bsky.social who demonstrated that NR2F2 is an important target in endocrine-resistant breast cancer! #SABCS24

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Marie Will, MD, PhD @marie-will.bsky.social · 14/12/2024

This is a dream team for the amazing work on DREAM complex! #SABCS24

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Marie Will, MD, PhD @marie-will.bsky.social · 14/12/2024

What’s the point of social media if you can’t brag about your friends? So proud of @avantikagupta.bsky.social and @saratchandarlapaty.bsky.social for their groundbreaking work showing how APOBEC-driven mutagenesis ➡️ key genomic alterations ➡️ therapy resistance in breast cancer. #SABCS24

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Marie Will, MD, PhD @marie-will.bsky.social · 12/12/2024

I still remember when @saratchandarlapaty.bsky.social & team discover ESR1 mutations in breast cancer by painstakingly analyzing patient samples and building lab models. Over a decade later, SERDs like imlunestrant show clear survival benefits in this population. Follow the science. #sabcs24

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Marie Will, MD, PhD @marie-will.bsky.social · 09/12/2024

Great story of oncology progress over the decades. Look at the curves. Success came via a couple of breakthroughs, yes, but also via smaller improvements that together make a steady progress. You often hear studies dismissed as “incremental,” but keep chipping away, every incremental step counts.

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Marie Will, MD, PhD @marie-will.bsky.social · 07/12/2024

Overall response rate (ORR) of 100%! Now with long term data showing 5-yr-Progression Free Survival (PFS) of 91%. Neither Pembro nor GVD alone is as efficacious, begging the mechanistic question of “synergy” - that is, how do immunotherapy and chemotherapy combine to become more than either alone?

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Marie Will, MD, PhD @marie-will.bsky.social · 03/12/2024

On matching, for my local folks, 2X at the Greater Boston Food Bank today. There are so many HCWs in this area - surely y’all aren’t just gathering here for this ridiculous cold weather! Flex your HCW density and feed some local folks! Team #DiagnoseAndTreats, let’s go! my.gbfb.org/give/629477/...

my.gbfb.org

The Greater Boston Food Bank

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Marie Will, MD, PhD @marie-will.bsky.social · 03/12/2024

OMG - the pediatricians are not messing around! Have you heard about their very deep pockets? No! All they’ve got is unlimited super power, boundless enthusiasm, and eternal kid love! So how come we are in 2nd place?? Come on, onc team #DiagnoseAndTreats, diagnose and treat this! #HCWvsHunger

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Marie Will, MD, PhD @marie-will.bsky.social · 02/12/2024

Hey onc peeps! Our team this year for #HCWvsHunger is #DiagnoseAndTreats - let’s go! Yes, poverty/food insecurity is a policy issue - even a policy *choice* in our society - and should be addressed as a system. But.. look around…policies won’t get fixed anytime soon and people need our help now!

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Marie Will, MD, PhD @marie-will.bsky.social · 30/11/2024

Vaccines are being attacked left and right BECAUSE they work so well that people have conveniently forgotten about polio and poxes. Here is a contemporary example in oncology. Vaccines prevent cancer and reduce cancer deaths - do you know how hard THAT is?? Spread the words - vaccine save lives!

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Marie Will, MD, PhD @marie-will.bsky.social · 27/11/2024

A bench-to-bedside targeted therapy story! Fatal disease ➡️ patient samples ➡️ deep proteomics ➡️ find target (jak/stat) ➡️ realize drugs exist ➡️ try drugs in lab ➡️ it works! ➡️ give drugs to patients ➡️ holy cow it actually works!!!! ➡️ save lives. This is the dream. Nice work @tnordmann.bsky.social

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Marie Will, MD, PhD @marie-will.bsky.social · 25/11/2024

If you don’t make the baklava, you won’t have a source for the energy you need for the grant!

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