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Mari B. Gornitzka

@maribgo.bsky.social
70 followers 163 following 2 posts

PhD fellow in immunogenetics @ University of Oslo | I like ripped genes, long genes, baggy genes and double genes

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Reposted by Mari B. Gornitzka
Andreas Lossius @lossiusandreas.bsky.social · 22/09/2025
New BCR reconstruction tool for scRNA-seq: assembles full heavy & light chains and annotates constant regions. Check it out: www.biorxiv.org/content/10.1... #scRNAseq #immunology
biorxiv.org
GATHeR: Graph-based Accurate Tool for Immunoglobulin HEavy- and Light-chain Reconstruction
Recovering full-length, paired B-cell receptor (BCR) sequences from scRNA-seq reads remains difficult, especially in naive and memory B cells where immunoglobulin transcripts are sparse. Current metho...
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Mari B. Gornitzka @maribgo.bsky.social · 22/09/2025
Interested in BCR analysis, including paired heavy-light chain and constant region?👀 Check out our new tool for reconstructing BCRs from scRNAseq! Compatible with 10x and Smart-seq🧬 www.biorxiv.org/content/10.1...
biorxiv.org
GATHeR: Graph-based Accurate Tool for Immunoglobulin HEavy- and Light-chain Reconstruction
Recovering full-length, paired B-cell receptor (BCR) sequences from scRNA-seq reads remains difficult, especially in naive and memory B cells where immunoglobulin transcripts are sparse. Current metho...
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Mari B. Gornitzka @maribgo.bsky.social · 14/02/2025
*constant*ly amazed 🧬
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Reposted by Mari B. Gornitzka
Corey Watson @cdubsig.bsky.social · 18/12/2024
Check out long-read sequencing results in human IGH! HUGE duplications in constant gene regions...and 7 copies of IGHV3-23 on one haplotype! @lossiusandreas.bsky.social @williamlees.bsky.social www.biorxiv.org/content/10.1...
biorxiv.org
Ultra-long sequencing for contiguous haplotype resolution of the human immunoglobulin heavy chain locus
Genetic diversity within the human immunoglobulin heavy chain (IGH) locus influences the expressed antibody repertoire and susceptibility to infectious and autoimmune diseases. However, repetitive seq...
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Reposted by Mari B. Gornitzka
Andreas Lossius @lossiusandreas.bsky.social · 18/12/2024
Our collaborative paper on #Nanopore sequencing is now available on #BioRxiv. Among several new variants, we characterize a large duplication in the IGHC region, suggesting non-canonical class switching between the duplicated isotypes in #Bcells. www.biorxiv.org/content/10.1...
biorxiv.org
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