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Manoj Doss not exist @manojdoss.bsky.social · 06/10/2026

Go check out the exhibit in Toronto before December!

Manoj Doss not exist @manojdoss.bsky.social · 05/10/2026

Came for TV on the Radio (& Beach House & The Strokes), stayed for @aoc.bsky.social & @sanders.senate.gov. What a family experience in NYC with my sister, brother-in-law, & my revolutionary wife Lucía.

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Manoj Doss not exist @manojdoss.bsky.social · 29/09/2026

Together, *might* suggest dissociable effects of psychedelics and dissociatives on WM capacity vs. precision: capacity less impaired by dissociatives, precision less impaired or even enhanced by psychedelics.

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Manoj Doss not exist @manojdoss.bsky.social · 29/09/2026

Interesting when 1) a 5-HT2A agonist sharpened neural tuning/precision of working memory representations (www.jneurosci.org/content/22/7...) and 2) working memory capacity (rather than precision) tends to be more readily impaired by 5-HTA psychedelics compared to NMDA dissociatives.

jneurosci.org

The Physiological Role of 5-HT2A Receptors in Working Memory

Dorsolateral prefrontal cortex has an essential role in the cognitive process of working memory, dysfunction of which is considered to be a core deficit in schizophrenia. Although this cortical region...

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Manoj Doss not exist @manojdoss.bsky.social · 27/09/2026

“Muscimol killed mice at a lower dose than nearly all psychotropic drugs we examined, including fentanyl.” That can’t be right when muscimol is active in milligrams and fentanyl is active in micrograms.

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Sam Cooper PhD @samcooper.bsky.social · 21/09/2026

Culmination of many years of work and thought in my little sub area of psych and neuro. Big thanks to @gushennings.bsky.social and @plaing94.bsky.social for helping bring this one home. We hope it provokes thought and improvement in the realm of fear generalization research.

screenshot of title of trends in cognitive sciences review titled "trends in cognitive neuroscience"

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M.J. Crockett @mjcrockett.bsky.social · 13/09/2026

I used to love this time of year, hearing from students applying to work in my lab. No more. Every day a fresh batch of nearly identical emails with nonsensical remixes of the text on my lab website. It makes me so sad.

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Manoj Doss not exist @manojdoss.bsky.social · 10/09/2026

Wow. Jim Pekar is so ahead of his time that he's publishing in the future!

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Manoj Doss not exist @manojdoss.bsky.social · 09/09/2026

Lastly, it was great catching meeting my soon-to-be co-author David Lawrence. Watch this space for more bizarre psychedelic effects on familiarity!

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Manoj Doss not exist @manojdoss.bsky.social · 09/09/2026

My chapter in the exhibit book! I should have taken more pics, but I had to capture the fact that they included Kid Cudi among psychedelic music (something I 100% agree with!)

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Manoj Doss not exist @manojdoss.bsky.social · 09/09/2026

I had an incredible visit to Toronto, and it was such an honor to see my work on display at the psychedelics exhibit at @romtoronto.bsky.social. They worked so hard on this, so please check it out before December 6! #lakeontario

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Manoj Doss not exist @manojdoss.bsky.social · 02/09/2026

Austin, TX & surrounding community: We're testing the effects of psychedelics on brain function & cognition. This is not for mental health treatment, and there'll be several cognitive tasks (no lying on a couch or eyeshades), but you'll be supporting science! Please share!

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Manoj Doss not exist @manojdoss.bsky.social · 28/08/2026

Have you had a creative insight related to your work/hobby that you think was due to a psychedelic experience? Please complete this survey! Note that we don't want personal insights (e.g., "I should quit my job" or "I had a bad relationship with my boss"). tiny.cc/PsychedelicsInsights

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Manoj Doss not exist @manojdoss.bsky.social · 28/08/2026

So the “line-of-sight” method we used was simple but is probs going out of fashion in favor of acoustic modeling, which is what we plan on doing next but is complicated. There’s a side of me that thinks just wait for the devices that do both targeting and sonication, but no idea how much those cost.

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Manoj Doss not exist @manojdoss.bsky.social · 28/08/2026

Yeaaaah memory was our primary interest, but Joey had an already programmed task laying around, so we threw that in last minute. Honestly surprised that the effects converged. But as a non-face person who hasn’t kept up with that lit, curious what’s problematic about emo labels and morphed faces?

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Manoj Doss not exist @manojdoss.bsky.social · 27/08/2026

Thanks Joey Dunsmoor for doing what I thought would be a necessary but not necessarily groundbreaking study that ended up raising more questions. He just had an R21 awarded in which we’ll attempt a replication and use fMRI and more advanced methods for amygdala targeting. 10/10

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Manoj Doss not exist @manojdoss.bsky.social · 27/08/2026

2 decades ago, work by Bryan Strange & others suggested a filtering function of the amygdala including less filtering in patients w/amygdala lesions. 9/10 www.pnas.org/doi/full/10.... doi.org/10.1523/JNEU... doi.org/10.1523/JNEU... doi.org/10.1017/S003... doi.org/10.1515/REVN...

pnas.org

PNAS

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

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Manoj Doss not exist @manojdoss.bsky.social · 27/08/2026

I realize this reinterpretation of amygdala function based on new-ish technology that we don’t fully understand is massively speculative, but we’re not the first to suggest that the amygdala may act as a filter. 8/10

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Manoj Doss not exist @manojdoss.bsky.social · 27/08/2026

A study by @brainscout.bsky.social found intracranial amygdala stimulation immediately after the presentation of a stimulus enhanced memory. One interpretation could be they turned up the filter AFTER a stimulus was processed which reduced retroactive interference. 7/10 www.pnas.org/doi/10.1073/...

pnas.org

PNAS

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Manoj Doss not exist @manojdoss.bsky.social · 27/08/2026

Both salience amplification & filtering would produce enhancements in emo vs neutral memory but only a filtering account would predict that inhibiting the amygdala would enhance memory (letting more stuff in). Likewise enhancing amygdala function should turn up filtering &…6/10

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Manoj Doss not exist @manojdoss.bsky.social · 27/08/2026

Assuming this tFUS protocol is in fact inhibitory, what could be happening? There’s a lot of speculation in the discussion, but one possibility is that instead of the amygdala enhancing the processing of salient stimuli, it instead filters non-salient information. 5/10

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Manoj Doss not exist @manojdoss.bsky.social · 27/08/2026

This tFUS protocol inhibits BOLD fMRI activity tho this isn’t definitive that it’s inhibitory. Greg Fonzo (a co-author) found 15 daily sessions w/this protocol was therapeutic in depression, anxiety, and PTSD in which the amygdala is thought to be on “overdrive.” 4/10 doi.org/10.1038/s413...

doi.org

Low-intensity transcranial focused ultrasound amygdala neuromodulation: a double-blind sham-controlled target engagement study and unblinded single-arm clinical trial - Molecular Psychiatry

Molecular Psychiatry - Low-intensity transcranial focused ultrasound amygdala neuromodulation: a double-blind sham-controlled target engagement study and unblinded single-arm clinical trial

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Manoj Doss not exist @manojdoss.bsky.social · 27/08/2026

We also found that tFUS enhanced fear discrimination in faces, which correlated with the memory enhancements (thanks to a reviewer for this suggestion!) 3/10

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Manoj Doss not exist @manojdoss.bsky.social · 27/08/2026

Instead, we enhanced episodic memory (regardless of emotion)! tFUS was administered to the left amygdala before memory encoding & memory was tested on a couple different tests 24 hours later, presumably when tFUS effects dissipate, thereby minimizing effects on retrieval. 2/10

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Jörn Alexander Quent @jaquent.bsky.social · 13/08/2026

Most of us agree that impact factor is a flawed measure/concept but I still wonder what happened to all these solid small journals, which now barely get above 1? There are memory journals, which when I started studying in the 2010s were really good but now all suffer from this decline.

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Manoj Doss not exist @manojdoss.bsky.social · 31/07/2026

Peep what Raquel Kosted and I had to say during ICPR 2026! Raquel - www.youtube.com/watch?v=CwWL... Me - www.youtube.com/watch?v=6e2f... (I was recovering from a cold, so I probably sound funny)

youtube.com

Raquel Kosted | ICPR 2026 | OPEN Foundation

YouTube video by OPEN Foundation

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Leah Banellis @leahbanellis.bsky.social · 23/07/2026

Sensing your body (‘Interoception’) is everywhere in theories of mental health. But when we tested how well hundreds of people sensed their heart and lungs, the link to symptoms was almost nowhere to be found. 💣 🚨New @natmentalhealth.nature.com paper 🚨🎉 asks why 🧵 www.nature.com/articles/s44...

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Bita Moghaddam @bita137.bsky.social · 21/07/2026

Our new study ⬇️inspired by the question: does psilocybin influence meta-learning and cortical processing of unexpected uncertainty? Why is this important? Meta-learning may be critical for therapeutic effects of psychedelics and how the trip creates a window that facilitates clinical intervention

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Manoj Doss not exist @manojdoss.bsky.social · 11/07/2026

🤮 Well I now know what journal I’m never going to review for.

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Manoj Doss not exist @manojdoss.bsky.social · 03/07/2026

Peep my dude Samuli’s (@kangaslampi.bsky.social) interview on psychedelics and (false) memory recovery by the inimitable Shayla Love (@shaylalove.bsky.social). “…perhaps it’s never too late to have a traumatic childhood if you really go looking for it.” Brilliant!

themicrodose.substack.com

Do psychedelics create false memories? 5 Questions with psychologist Samuli Kangaslampi

Kangaslampi discusses the need to study autobiographical memories that may emerge during trips.

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Manoj Doss not exist @manojdoss.bsky.social · 01/07/2026

Researchers in cognitive neuroscience (eg, @tobiasegner.bsky.social) have also come to the conclusion that the stability-flexibility conceptualization is an oversimplification, and instead, different learning processes may better capture flexible decision-making. www.nature.com/articles/s44... 12/12

nature.com

Principles of cognitive control over task focus and task switching - Nature Reviews Psychology

Adaptive behaviour requires the ability to maintain focus on a task and to flexibly switch tasks, depending on the context. In this Perspective, Egner integrates the task focus and task switching lite...

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Manoj Doss not exist @manojdoss.bsky.social · 01/07/2026

This model is certainly oversimplified, but it better captures the literature than the unidimensional stability-flexibility continuum, and what’s interesting is that recently...11/12

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Manoj Doss not exist @manojdoss.bsky.social · 01/07/2026

Perhaps if someone w/addiction relapses following psychedelic therapy, they may even be able to better realize that their addiction is no longer bringing them the rewards that they experienced when their addiction began (tho I realize this is a pretty big conceptual leap). 10/12

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Manoj Doss not exist @manojdoss.bsky.social · 01/07/2026

When one’s grandiose idea turns out to not produce the rewards they may expect, they may quickly learn that this idea is not worth pursuing, hence most people not feeding into a bizarre idea conjured up on psychedelics. 9/12

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Manoj Doss not exist @manojdoss.bsky.social · 01/07/2026

Perhaps this could relate to how during acute psychedelic effects, one can have a grandiose idea that can be borderline delusional. However, this can be offset by the post-acute enhancements in learning from reward omission…8/12

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Manoj Doss not exist @manojdoss.bsky.social · 01/07/2026

While this model isn’t perfect, it does capture tendencies in the literature. For example, during acute psychedelic effects, learning that a stimulus is rewarding can be so enhanced that one may perseverate such that learning a new stimulus is rewarding may become difficult. 7/12

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Manoj Doss not exist @manojdoss.bsky.social · 01/07/2026

Both of these processes seem to get enhanced during the acute and post-acute effects, but learning from reward receipt is disproportionately enhanced during acute effects, whereas learning from reward omission is more enhanced post-acutely. 6/12

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Manoj Doss not exist @manojdoss.bsky.social · 01/07/2026

I didn’t tell Raquel to frame this around learning & memory, but to my delight as a memory researcher, she came up with a model that involved two learning processes that largely captured the literature: learning from reward receipt and learning from reward omission. 5/12

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Manoj Doss not exist @manojdoss.bsky.social · 01/07/2026

During Raquel first year, I put her up to the task of reviewing the literature and seeing if she could delineate the conditions (e.g., tasks, timing of drug, pharmacology of drug, etc.) that produce the varied results. 4/12

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Manoj Doss not exist @manojdoss.bsky.social · 01/07/2026

Some have said that this is because the brain is on a unidimensional stability-flexibility continuum, & the acute effects of psychedelics tip it too far into flexibility while the post-acute effects make the brain just flexible enough. As we discuss, this is far too simple. 3/12

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Manoj Doss not exist @manojdoss.bsky.social · 01/07/2026

So the idea for this review started while I was writing this paper www.nature.com/articles/s41.... I realized that there were several animal & human studies on psychedelics and cognitive flexibility, some showing impairments, some showing enhancements, and some showing no effects. 2/12

nature.com

Psilocybin therapy increases cognitive and neural flexibility in patients with major depressive disorder - Translational Psychiatry

Translational Psychiatry - Psilocybin therapy increases cognitive and neural flexibility in patients with major depressive disorder

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Manoj Doss not exist @manojdoss.bsky.social · 20/06/2026

Lol I actually dropped that years ago on my Twitter! The way people do their tricks has always fascinated me. Most bladers remember the skates someone has but I always remember which way people do their tricks (& there’s a largely predictable pattern dependent on foot dominance and spin direction).

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Manoj Doss not exist @manojdoss.bsky.social · 20/06/2026

This is interesting to me because in rollerblading, I tend to see more left vs. right spinners, including myself (see clip below). Left spinners will even do tricks/grinds with their non-dominant foot/feet positioning to avoid spinning to the right, something I rarely see with right spinners.

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Manoj Doss not exist @manojdoss.bsky.social · 15/06/2026

I don’t think funding currently favors any one model, and I think many are aware that there are lots of untested assumptions. Almost certainly no one is going to ding your grant for not providing the full spa treatment and not playing lame music haha

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Manoj Doss not exist @manojdoss.bsky.social · 15/06/2026

Was quoted in @theatlantic.com regarding efforts to create new psychedelic drugs. Lol they mention my disdain for the overhyped Hopkins playlist. www.theatlantic.com/health/2026/...

theatlantic.com

The New Science of Psychedelic Drugs

University researchers are looking for ways to engineer better mind-altering therapeutic experiences

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