iiinova — where your digital self keeps evolving

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American Society of Clinical Oncology @ascocancer.bsky.social · 31/05/2026

The final study presented at #ASCO26 Plenary: RASolute-302 results show daraxonrasib meeting all primary and key secondary endpoints, demonstrating significant and clinically meaningful improvements in OS, PFS, and ORR in metastatic #PDAC: bit.ly/49r62n1 #ASCODailyNews

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Dr. Glaucomflecken @glaucomflecken.bsky.social · 11/05/2025

youtube.com/shorts/CuSwN... I made some people big mad with this one

youtube.com

The Dangers of Raw Milk

YouTube video by Dr. Glaucomflecken

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Alastair Lamb @lambalastair.bsky.social · 29/04/2025

Really enjoyed this deep dive into intratumoural immune archetypes from Matt Krummel #AACR25 @TheAACR.bsky.social Loved this video on T Cell vs Dendritic Cell interacting #IntratumouralHeterogeity #ClonalEvolution #ReactiveImmunity

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Johanna Joyce @johannajoyce.bsky.social · 29/04/2025

Powerful insights into metastatic evolution and the importance of the microenvironment by Mariam Jamal-Hanjani A brilliant plenary session on “Targeting the Cancer Ecosystem” - thanks to all four speakers and @marasherman.bsky.social for wonderful chairing 👏 #AACR2025 @theaacr.bsky.social

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manjuggm.bsky.social @manjuggm.bsky.social · 25/04/2025

Excited to learn from this awesome panel at #AACR2025 as we talk about EO Cancers & their rising rates As an early onset #colorectalcancer survivor & as someone who sees the impact of #EOCRC daily in #COLONTOWN, we need more concerted efforts to reduce the burden of EOCRC worldwide. lnkd.in/drM7X2PS

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manjuggm.bsky.social @manjuggm.bsky.social · 25/04/2025

Thrilled to participate in this hashtag#AACR2025 session on Regulatory Trends Shaping the Future of Cancer Drug Development and learn from these experts! lnkd.in/d4WTshuY See you there!

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Eric Topol @erictopol.bsky.social · 27/03/2025

There are so many ways to rev up our immune response against cancer. Here, the oncolytic viruses www.cell.com/cancer-cell/...

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Chise @sailorrooscout.bsky.social · 15/03/2025

the tens of thousands who suffer from the illness, especially in African nations where the disease is prevalent. You can read all this and more here: • www.cbsnews.com/newyork/news... • www.yahoo.com/news/long-is... • www.nhlbi.nih.gov/health/sickl... • www.fda.gov/news-events/... • www.lyfgenia.com

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Chise @sailorrooscout.bsky.social · 15/03/2025

is also looking to re-enroll in school to pursue a medical career, inspired by his own journey. Contributions have been made to Northwell Health, supporting the organization's continuing efforts in treating sickle cell disease, a move that signifies hope for the availability of the gene therapy for

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Chise @sailorrooscout.bsky.social · 15/03/2025

had to stay in the hospital for about another month and said that January 13th was the day he felt like a new person as things kicked in. Beauzile says he’s not in pain anymore, and that he’s been able to do a lot of new things, including finally having the first chance for a carefree vacation. He

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Chise @sailorrooscout.bsky.social · 15/03/2025

In late December, Sebastien’s stem cells were successfully re-infused back into him in a matter of minutes. Now he’s producing normal adult hemoglobin in his parent cells and that’s why he’s not having any symptoms related to his sickle cell disease according to his doctors. For assurances, Beauzile

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Chise @sailorrooscout.bsky.social · 15/03/2025

treated with Lyfgenia in the lab before being infused back via a stem cell transplant. Before the procedure, the patient must undergo a round of high-dose chemotherapy to eliminate faulty blood stem cells and make room for new ones.

Treatment Process
STEP 1: LYGENIA is made specifically for you from your own blood stem cells. Your healthcare provider will collect your blood stem cells through a procedure/ process called mobilization and apheresis. This process takes approximately one week and may need to be repeated to obtain a sufficient number of cells.
'Back-up' stem cells (or 'rescue cells') are also collected and stored at the treatment center. This is a precaution in case there is a problem in the treatment process. If this happens, your back-up stem cells will be given back to you. If you receive back-up cells, you will have no benefit from LYFGENIA.
STEP 2: Your blood stem cells will be sent to a manufacturing site where they are used to make your
LYFGENIA. It typically takes 10 to 15 weeks from the time your cells are collected to make and test LYFGENIA before it is shipped to your healthcare provider, but the time may vary and be up to 22 weeks.
STEP 3: Before you receive LYGENIA, your healthcare provider will give you chemotherapy for a few days to make room in the bone marrow. You will be admitted to the treatment center for this step and remain there until after LYGENIA infusion.
STEP 4: LYFGENIA is given by an intravenous infusion.
You may receive more than one bag of LYFGENIA. Each bag is infused in 30 minutes or less.
After LYGENIA infusion, you will stay in the treatment center for approximately 3-6 weeks so that your healthcare team can closely monitor your recovery. Your healthcare provider will determine when you can go home.

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Chise @sailorrooscout.bsky.social · 15/03/2025

patient, and creates a new, healthy gene inserted into parent cells that connect to the stem cells of red blood cells afflicted by the illness instead of more painful procedures like bone marrow transplants. Patients’ own hematopoietic stem cells, or blood cell precursors, are collected and then

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Chise @sailorrooscout.bsky.social · 15/03/2025

treatment of sickle cell disease in patients 12 years of age and older with a history of vaso-occlusive events (VOEs). Lyfgenia delivers a modified version of the HBB gene that can produce a form of hemoglobin (HbAT87Q) that’s resistant to clumping or sickling. It is made SPECIFICALLY for each

Figure 1. Basic Elements of the LYFGENIA Gene Therapy Process

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Chise @sailorrooscout.bsky.social · 15/03/2025

was FDA approved in late 2023, Sebastien was the first patient on their minds, and it changed his life dramatically. Lyfgenia is a one-time gene therapy used to treat sickle cell disease in patients 12 years of age or older and a history of vaso-occlusive events. It was approved by the FDA for the

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Chise @sailorrooscout.bsky.social · 15/03/2025

Northwell facility in New Hyde Park. He couldn’t travel without going to a hospital, had a hard time working a job, and had to stop going to Queens Community College because of recurring issues with the disease, which made his life substantially challenging. When Lyfgenia became available when it

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Chise @sailorrooscout.bsky.social · 15/03/2025

and intense pain if damaged red blood cells block vessels and restrict oxygen supply, which can also lead to strokes and heart failure. Beauzile, had his first of many crises from his extremely severe case of sickle cell as a 4-month-old baby. Since then, he has consistently been in and out of the

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Chise @sailorrooscout.bsky.social · 15/03/2025

mutation (mutation in the HBB gene) causes red blood cells to become irreversibly sickle shaped, which can lead to haemolytic anaemia- a blood condition that occurs when your red blood cells are destroyed faster than they are replaced. Over a long period, the disorder can cause severe organ damage

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Chise @sailorrooscout.bsky.social · 15/03/2025

descent. According to the center’s Director of Pediatric Hematology, Oncology, and Stem Cell Transplantation: THIS IS A FIX. Other drugs modify the disease, but this is a CURE and they suspect this genetic treatment will replace bone marrow transplants in time. In sickle cell disease, a gene

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Chise @sailorrooscout.bsky.social · 15/03/2025

In a significant medical breakthrough, Long Island's Sebastien Beauzile has become the first person in New York to be cured of sickle cell anemia, a genetic disease that causes chronic pain and a host of other health issues, primarily affecting people of African, Mediterranean, and Middle Eastern

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Chise @sailorrooscout.bsky.social · 15/03/2025

THIS IS INCREDIBLE! Cohen Children’s Medical Center has confirmed that it has successfully ELIMINATED sickle cell disease from Sebastien Beauzile, using the groundbreaking genetic treatment Lyfgenia. He has made HISTORY by becoming the FIRST in New York to be CURED of sickle cell anemia! 🧪🧵⬇️

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Chise @sailorrooscout.bsky.social · 13/03/2025

THIS IS HUGE! Researchers at Cornell University have developed a new thermostable, MULTI-TARGET vaccine platform that offers stronger, longer-lasting protection against SARS-CoV-2 AND influenza while providing broader immunity against VARIOUS flu strains. 🧪🧵⬇️

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Eric Topol @erictopol.bsky.social · 12/03/2025

An important graph and caption on the impact of Covid www.nytimes.com/interactive/...

Disability increase from COVID in the US graph

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Angie Rasmussen @angierasmussen.bsky.social · 10/03/2025

My co-EIC Florian Krammer wrote this commentary in Vaccine on the need for next generation flu vaccines to have a NA component (the N in H5N1 or H3N2). It’s a smart idea & safeguards against bad matches to HA & other subtypes that share N1 or N2.

Screenshot of article linked here: https://pdf.sciencedirectassets.com/271205/1-s2.0-S0264410X25X00098/1-s2.0-S0264410X25002919/main.pdf

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Chise @sailorrooscout.bsky.social · 09/03/2025

THIS IS HUGE! Researchers at Stanford University have developed a dual-antibody treatment that remains effective against ALL SARS-CoV-2 variants by targeting a less-mutable part of the virus. This breakthrough could lead to longer-lasting therapies that OUTPACE viral evolution. 🧪🧵⬇️

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Missy Hubbard @missy-ubermom.bsky.social · 08/03/2025

We have these up in VA02…

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Ida Bae Wells @nhannahjones.bsky.social · 07/03/2025

My hometown of Waterloo, Iowa canceled its African American Read-In after Trump’s anti-diversity directives. So i got together some writer friends and I’m holding it instead.

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manjuggm.bsky.social @manjuggm.bsky.social · 06/03/2025

Very little can help my general mood of despair, but my goodness, this did.. x.com/timjacobwise...

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Shematologist, MD @shematologist.medsky.social · 04/03/2025

And if that doesn't warm your heart, he only retired due to rules that in Australia you can't donate past the age of 81! So cheers to Mr. Harrison, a long life full of helping others, and all the babies he saved. May we all bring such good into the world. 18/fin

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Shematologist, MD @shematologist.medsky.social · 04/03/2025

Mr. Harrison's antibodies were likely due to his prior surgery. He is one of <50 people in Australia known to have the antibodies. As of 2018 (when he retired), every batch of anti-D ever made in Australia had come from his blood! And his own daughter received anti-D! 17/n

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Shematologist, MD @shematologist.medsky.social · 04/03/2025

Prior to the development of anti-D 16% of D- women were allo-immunized after 2 deliveries of D+ babies. A single dose of anti-D decreased this rate to 1-2%, and an additional dose in 3rd trimester led to only 0.1-0.3%! 16/n

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Shematologist, MD @shematologist.medsky.social · 04/03/2025

And the answer is, we don't really know. Possibilities: -rapid clearance of anti-D coated RBCs occurs before an immune response can -down regulation of antigen specific B cells But the important thing is that it WORKS! 15/n

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Shematologist, MD @shematologist.medsky.social · 04/03/2025

Once he became a donor, doctors discovered that his blood contained the antibody that could be used to make anti-D immune globulin! Anti-D is manufactured from pooled plasma selected for high titers of IgG antibodies to D-positive RBCs. But wait, how can that work? 14/n

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Shematologist, MD @shematologist.medsky.social · 04/03/2025

So what about our hero? Mr. Harrison had major surgery at the age of 14 and blood donations saved his life. He pledged to become a blood donor! 13/n

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a poster encouraging people to donate blood to save lives .

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Shematologist, MD @shematologist.medsky.social · 04/03/2025

But as we all know, prevention is always better than treatment! If mothers are D- with negative antibody screen, and possible D+ fetus, they are candidates for preventive anti-D immune globulin. If antibodies positive, they should not receive as it will be ineffective. 12/n

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Shematologist, MD @shematologist.medsky.social · 04/03/2025

Further monitoring/treatment depends on clinical scenario and may involve: -following anti-D titers -ultrasound assessments -intrauterine transfusions -maternal plasmapheresis and IVIG (investigational) 11/n

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Shematologist, MD @shematologist.medsky.social · 04/03/2025

So what can be done about this? D typing and antibody screening is performed at 1st prenatal visit. If negative plus uncomplicated pregnancy, testing is repeated at 28 weeks and delivery. If anti-D antibody is detected, the fetal D type is determined. 10/n

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Shematologist, MD @shematologist.medsky.social · 04/03/2025

Transplancental transfer of maternal antibody leads to hemolytic disease of the fetus and newborn. This can lead to hydrops fetalis (skin edema, pleural and pericardial effusion, ascites) when fetal hemoglobin is <5g/dL. 9/n

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Shematologist, MD @shematologist.medsky.social · 04/03/2025

D-antigen is thought to elicit a strong immune response but this varies considerably Interestingly, risk of sensitization to D is decreased if the fetus and mother are ABO incompatible. Any leaked cells are rapidly destroyed by anti-A/B reducing the likelihood of exposure. 8/n

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Shematologist, MD @shematologist.medsky.social · 04/03/2025

Once mother's immune system is exposed, anti-D IgG antibodies form. These antibodies cross the placenta, where they opsonize fetal RBCs (make them more likely to be phagocytized (ingested) by macrophages). These RBCs are then phagocytized by macrophages in the fetal spleen. 7/n

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Shematologist, MD @shematologist.medsky.social · 04/03/2025

Alloimmunization occurs when a mother who is RH negative (lacking D) is exposed to D-positive RBCs. This can occur through transplacental fetomaternal bleeding (virtually all), injection with contaminated needles, inadvertent transfusion or D-mismatched stem cell transplant. 6/n

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Shematologist, MD @shematologist.medsky.social · 04/03/2025

Prevalence of D-negative blood type varies considerably among populations from up to 35% in Basques to only 0.3% in Chinese. By 38 days gestation, the D antigen is present on RBCs. Unlike most other antigens, it is only present on RBCs. 5/n

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Shematologist, MD @shematologist.medsky.social · 04/03/2025

In obstetrics, blood type is designated as ABO type plus RH status (positive or negative). This refers whether the woman has the D antigen on her red blood cells. (although technically the Rh system consists of 48 antigens, with the most common being D, C, c, E, and e) 4/n

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Shematologist, MD @shematologist.medsky.social · 04/03/2025

How could one man save so many? And why is his blood any different than the rest of us? It all goes back to alloimmunization, a problem in pregnancy whereby mothers develop antibodies against certain antigens on their child's red blood cell. 3/n

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Shematologist, MD @shematologist.medsky.social · 04/03/2025

James Harrison was known as the "Man with the Golden Arm." He donated blood almost weekly for 60 years, and in that time helped save the lives of >2.4 million Australian babies! 2/n

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Shematologist, MD @shematologist.medsky.social · 04/03/2025

A legend died today. In his memory, how about a heartwarming heme #skeetorial? #hemesky #nerdalert Today the world lost the man with the "golden arm" 1/n

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Carl T. Bergstrom @carlbergstrom.com · 02/03/2025

In the LA area? I'm speaking at UCLA's Marschak Colloquium on Tuesday at 1 PM PST on Tuesday. Not in the LA area? You can RSVP to attend by zoom. www.library.ucla.edu/visit/events...

Event flier:

The Crisis of Human Collective Decision-making in a Social Media World
March 4, 2025
1:00 pm - 2:30 pm

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Angie Rasmussen @angierasmussen.bsky.social · 28/02/2025

Parents who choose not to vaccinate often do so for 2 reasons, both wrong: 1. They think measles is harmless. 2. They think the vaccine is harmful. Measles can be deadly & cause long term disability. Kids are at highest risk. MMR vaccines are safe & prevent measles.

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