Background:Despite the growing role of genetic testing in pediatric kidney disease, translating genomic findings into clinical care remains...

Steroid-resistant nephrotic syndrome (SRNS) is the leading cause of chronic glomerular disease in individuals under 25 years of age. Biallelic variants in NPHS2, encoding podocin, are the most common ...

BI 764198 lowered proteinuria and was well tolerated by participants in this trial. This is the first evidence of efficacy with a podocyte-targeted therapy in FSGS. Larger randomised controlled trials...