Reposted by @lukebsnell.bsky.socialAdela Alcolea-Medina @adelaam.bsky.social · 04/02/2026We show no improvement in pathogen detection or genome recovery X10 with longer turnaround time and higher failure rates for the dual-arm approach. 011
Reposted by @lukebsnell.bsky.socialAdela Alcolea-Medina @adelaam.bsky.social · 04/02/2026Our latest preprint compares the dual-arm nanopore workflow with the respiratory metagenomics protocol currently implemented across the NHS, using clinical samples. 👉 www.researchsquare.com/article/rs-8... @nhsmetagenomicsnet.bsky.social @lukebsnell.bsky.social @ronandoyle.bsky.socialresearchsquare.comComparison of nanopore methods for respiratory clinical metagenomicsRespiratory metagenomic sequencing is increasingly used for rapid, pan-microbial diagnosis in clinical practice, but there is a need to evaluate different wet lab protocols for performance and feasibi... 144
Reposted by @lukebsnell.bsky.socialStuart Neil @tetherin.bsky.social · 02/02/2026This is finally out. Very short take home. All the variation in spike that produced the immune escape characteristics of Omicron can occur in one single persistently infected individual over the period of a year. This is why persistent infections matter www.cell.com/cell-reports...cell.comAntibody escape drives emergence of diverse spike haplotypes resembling variants of concern in persistent SARS-CoV-2 infectionsSnell et al. develop sequencing methodology to identify full-length spike haplotypes and show that persistent SARS-CoV-2 infections drive divergent haplotype emergence, accelerating viral evolution an... 39550
Reposted by @lukebsnell.bsky.socialNHS Respiratory Metagenomics Network @nhsmetagenomicsnet.bsky.social · 13/11/2025What an inspiring day! Last week we hosted our second Network Day, bringing together over 120 people. We explored the development of the national pilot metagenomic service, which is improving detection & treatment of respiratory infections. Thank you to all who joined and to our fantastic speakers! 232
Reposted by @lukebsnell.bsky.socialmedRxivpreprint @medrxivpreprint.bsky.social · 10/10/2025Implementing rapid pan-microbial metagenomics in paediatric intensive care www.medrxiv.org/content/10.1101/202… 022
Reposted by @lukebsnell.bsky.socialThe Lancet Microbe @lancetmicrobe.bsky.social · 02/10/2025New research article Rapid pan-microbial metagenomics for pathogen detection and personalised therapy in the intensive care unit: a single-centre prospective observational study www.thelancet.com/journals/lan... #IDSky #ClinMicro #OpenAccess #OA 2216
