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Lucas A. Defelipe

@lucasdefelipe.bsky.social

106 followers 259 following 1 posts

Senior technical officer @ EMBL Hamburg. Biophysics and Structural Biology

Posts Replies Media

Reposted by Lucas A. Defelipe

SPC Facility & Garcia-Alai Lab @spcembl.bsky.social · 28/04/2025

🔊 Thrilled to share our latest work, just published in NAR! 📃 We present ChiraKit, open-source tool to process raw CD data and perform advanced analysis! Access via our eSPC web-server! ➡️ spc.embl-hamburg.de @osvalb.bsky.social @lucasdefelipe.bsky.social @embl.org @cssbhamburg.bsky.social

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Reposted by Lucas A. Defelipe

SPC Facility & Garcia-Alai Lab @spcembl.bsky.social · 31/01/2025

🔊 Our latest biophysical tool for circular dichroism analysis, ChiraKit, is out 🔍 To read more about it, visit www.biorxiv.org/content/10.1... ChiraKit can be accessed at spc.embl-hamburg.de @osvalb.bsky.social @lucasdefelipe.bsky.social @embl.org @cssbhamburg.bsky.social @mosbri.bsky.social

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Reposted by Lucas A. Defelipe

Osvaldo Burastero @osvalb.bsky.social · 18/11/2024

Just out! 🥳🥳 Great work done at the @spcembl.bsky.social to understand clathrin-mediated endocytosis. We investigated how clathrin and adaptor proteins interact in vitro and in vivo. Kudos to the 1st author @lucasdefelipe.bsky.social! www.nature.com/articles/s41... www.embl.org/news/science...

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Reposted by Lucas A. Defelipe

SPC Facility & Garcia-Alai Lab @spcembl.bsky.social · 18/11/2024

New preprint alert 🔔 ! New insights into the clathrin-mediated endocytosis machinery! Sla2 emerges as a central hub interacting with Clathrin Light Chains and the Pan1/End3/Sla1 complex. Read the full study: doi.org/10.1101/2024... #embl @cssbhamburg.bsky.social @lucasdefelipe.bsky.social

doi.org

Sla2 is a core interaction hub for Clathrin Light Chain and the Pan1/End3/Sla1 Complex

The interaction network of Sla2, a vital adaptor protein in the endocytic mid-coat, undergoes constant rearrangement incorporating or replacing interacting proteins over time. Sla2 serves as a scaffol...

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