Reposted by RM
Receptor clustering is a common theme in viral detection, but whether detection directly hinders genome replication is less clear.
Excited to share the Z in RZ-type E3s: ZNFX1 is an RNA helicase that builds ubiquitin chains leading to aggregates that ensnare viral RNA.
www.cell.com/molecular-ce...
cell.com
ZNFX1 uses two-component ubiquitin circuitry to quarantine viral RNA
Squair et al. show that ZNFX1 restricts ssRNA virus replication by integrating SF1
helicase activity with dual E3 ligase mechanisms. ATP-dependent RNA binding activates
E3 function, driving self-propa...
