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Leticia Pérez

@lperezsisques.bsky.social
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Reposted by Leticia Pérez
Alex Donovan @apadonovan.bsky.social · 11/09/2026
Our paper tying up some loose ends in our understanding of temporal patterning is out now! 🧠🪰 We show a single transcription factor (Tailless/TLX) terminates the temporal cascade across multiple neural stem cell lineages in the fly brain! journals.biologists.com/dev/article/...
journals.biologists.com
Tailless terminates the neural stem cell temporal cascade in both the optic lobe and central brain
Summary: Are temporal cascades conserved in different neural lineages? Combining genetic manipulation and chromatin-binding assays in Drosophila, this study identifies Tailless/TLX as a conserved fact...
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Reposted by Leticia Pérez
Karen J Liu @karenjliu.bsky.social · 20/08/2026
Postdoc and Tech post! 3-yr BBSRC project studying cell biology of Wnt signaling: advanced imaging, genome editing and embryology. Apply now! work with Matthias Krause and Karen Liu labs. @matthias-krause.bsky.social Tech: www.kcl.ac.uk/jobs/155666-... Postdoc: www.kcl.ac.uk/jobs/155745-...
kcl.ac.uk
Research Assistant | King's College London
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Reposted by Leticia Pérez
Spagnoli_Lab. @labspagnoli.bsky.social · 13/05/2026
💥 Great fun writing this #review with @alejotorrescano.bsky.social – reflecting on the emergence of #pancreatic #lineages in the #embryo through the lens of #plasticity - Just out online ➡️ rdcu.be/fiw3c @wellcometrust.bsky.social @kingscollegelondon.bsky.social @kingslsm.bsky.social
rdcu.be
Understanding development and cellular plasticity in the pancreas in health and disease
Nature Reviews Gastroenterology & Hepatology - Pancreatic development is a dynamic process. This Review discusses the development and cellular plasticity that occurs in the pancreas in health...
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Reposted by Leticia Pérez
Spagnoli_Lab. @labspagnoli.bsky.social · 03/02/2026
👀 Check out @the-node.bsky.social where @alejotorrescano.bsky.social (first author) share #behindthepaper stories about our recent paper ⤵️ Behind the paper: “Spatially organized cellular communities shape functional tissue architecture in the pancreas” thenode.biologists.com/behind-the-p...
thenode.biologists.com
Behind the paper: “Spatially organized cellular communities shape functional tissue architecture in the pancreas” - the Node
Behind the paper story from Alejo Torres Cano on their recent paper describing how spatially organized cellular communities shape functional tissue architecture in the pancreas.
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Reposted by Leticia Pérez
Ana Dorrego Rivas @adorrego.bsky.social · 16/12/2025
Here's the news piece from the IoPPN about our paper today! A wonderful way to end the year. www.kcl.ac.uk/news/structu...
kcl.ac.uk
Structure of dopamine-releasing neurons relates to the type of circuits they form for smell-processing | King's College London
Closely related subtypes of dopamine-releasing neurons may play entirely separate roles in processing sensory information, depending on their physical structure.
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Reposted by Leticia Pérez
Spagnoli_Lab. @labspagnoli.bsky.social · 14/12/2025
📣 New Pre-print from my lab to wrap-up year!!! 🎉 🎉 led by #GeorginaGoss with support from @alejotorrescano.bsky.social @heathermwilson.bsky.social & @habkcl.bsky.social Pairing #spatialtranscriptomics with #stemcell–derived #multilineage-organoids to elucidate human pancreatic islet development 💥
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Alejo Torres @alejotorrescano.bsky.social · 14/11/2025
Thrilled to see the work of my postdoc in the @labspagnoli.bsky.social finally published! Many thanks to all the co-authors for all the help!
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Spagnoli_Lab. @labspagnoli.bsky.social · 13/11/2025
🚨 Check out our new paper is now online in its final version!!! 🎉 👏 Congratulations @alejotorrescano.bsky.social who led the study + past & current team @labspagnoli.bsky.social + collaborators #VigilanteLab @kingslsm.bsky.social ➡️ doi.org/10.1126/scia... short 🧵 below & more acknowledgments ⤵️
doi.org
Spatially organized cellular communities shape functional tissue architecture in the pancreas
Spatial maps reveal dynamic epithelial-mesenchymal niches shaping pancreatic development and function.
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Reposted by Leticia Pérez
Cris Malagelada @crismalagelada.bsky.social · 08/10/2025
We are very happy to share with you this review pubished in @jneurochem.bsky.social @WileyGlobal.bsky.social . Very proud of all the students in the lab who contributed to craft this manuscript! EVs, mTOR and neuroinflammation. @ub.edu @ubneuro.bsky.social onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com
Tiny Messengers, Huge Consequences: Extracellular Vesicles and mTOR Signaling in Neuroinflammation
Neuroinflammation is a crucial mediator in the pathogenesis of multiple neurodegenerative diseases, acting not only as a consequence but also as a driver of disease progression. Yet, much remains to ....
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Reposted by Leticia Pérez
Karen J Liu @karenjliu.bsky.social · 05/08/2025
Dev biologists! 3-yr postdoc position at King's, collaboration with Trizzino lab @marcotrizzino.bsky.social modelling CHD3 neural crest. We are looking for postdocs with mad embryology skills @the-node.bsky.social #developmental @ccrb27.bsky.social thenode.biologists.com/jobs/postdoc...
thenode.biologists.com
Postdoctoral Research Associate: Modelling Neural Crest Anomalies (mouse/human) - the Node
The Liu lab is looking for a postdoc with a love of embryos and developmental biology! This post is part of an MRC-funded collaboration between Karen Liu’s lab at King’s College London and Marco Trizz...
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Spagnoli_Lab. @labspagnoli.bsky.social · 02/06/2025
We are doing it again!! 🚶‍♀️🚶‍♂️🚶🧪🧫🔬 For the Second Year My Lab is participating to the One_Walk_London 🎡 to raise money for life-changing research & make a difference to T1D #diabetes ⤵️ support.breakthrought1d.org.uk/fundraisers/... Please help us raise funds for @breakthrought1duk.bsky.social
support.breakthrought1d.org.uk
Spagnoli Lab. One Walk
Please help us raise vital funds for Breakthrough T1D, the leading global type 1 diabetes (T1D) research charity. Your support will help change the lives of everyone affected with T1D - Thanks so much...
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Universitat de Barcelona @ub.edu · 27/05/2025
#RecercaUB | 🧠 Un equip de @ubneuro.bsky.social ha descobert nous mecanismes moleculars relacionats amb el declivi cognitiu associat a la malaltia d’Alzheimer. 🎓 N’és la primera autora Almudena Chicote, membre de l’equip de Cristina Malagelada, de @medicinacs-ub.bsky.social.
web.ub.edu
Nova descoberta sobre els factors relacionats amb la progressió de la malaltia d’Alzheimer
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Cris Malagelada @crismalagelada.bsky.social · 07/05/2025
I'm excited to share our latest work as senior author, published in Alzheimer's & Dementia "Astrocytes, via RTP801, contribute to cognitive decline by disrupting GABAergic-regulated connectivity and driving neuroinflammation in AD" Very proud of this team! 🧪 Read it here: doi.org/10.1002/alz....
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Nature @nature.com · 05/05/2025
Nature research paper: Regulation of PV interneuron plasticity by neuropeptide-encoding genes. go.nature.com/4lWkesG
go.nature.com
Regulation of PV interneuron plasticity by neuropeptide-encoding genes - Nature
Increasing the activity of individual parvalbumin-expressing interneurons in the mouse brain modulates the number and strength of inhibitory parvalbumin synapses received by these cells through changes in the expression of the neuropeptide-encoding genes Vgf and Scg2.
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Alejo Torres @alejotorrescano.bsky.social · 18/04/2025
Happy to see the first bit of my postdoc work out! Have a look! 👀
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Reposted by Leticia Pérez
Spagnoli_Lab. @labspagnoli.bsky.social · 17/04/2025
🚨🚨 New pre-print from the lab. led by the amazing @alejotorrescano.bsky.social ! Alejo & Co. elegantly decode the spatial logic of progenitor cell organization in the developing pancreas — from individual cells to structured cellular communities 🔬🔬🧫🧪 Check-it out ⤵️
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The Transmitter @thetransmitter.bsky.social · 17/04/2025
An analysis of 20 autism mouse models point to two subtypes: One displaying out-of-sync brain activity and impaired synaptic pathways, the other with too much synchrony and dysregulated immune pathways. By @callimcflurry.bsky.social #neuroskyence www.thetransmitter.org/spectrum/too...
thetransmitter.org
Too much or too little brain synchrony may underlie autism subtypes
Functional connectivity differences in autism mouse models point to two subtypes that correspond to patterns seen in some people with the condition.
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Reposted by Leticia Pérez
Albert Giralt Lab @neurocientific.bsky.social · 15/04/2025
Do you want to help as a technician in a transaltional project in the context of Alzheimer's disease? Yes, we are hiring. 2-year contract. This is a straightforward collaboration between CIRCE Scientific and Creatio UB. See the offer also at: www.linkedin.com/feed/update/...
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