Reposted by Phil Drewniak
Interesting paper by the groups of @zhizhou1619.bsky.social and Xiang Sheng in @natcomms.nature.com. They developed a system, with which thiophenols can be fed to cells, converted into non-canonical amino acids and used for genetic code expansion in protein engineering.
nature.com
Design and evolution of artificial enzyme with in-situ biosynthesized non-canonical amino acid
Nature Communications - Enzyme design with non-canonical amino acids has achieved rapid progress in biocatalysis. Here, the authors present an efficient strategy for the design of artificial...