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Phil Drewniak

@lostmydeuteron.bsky.social
82 followers 276 following 5 posts

Protein dynamics, structural biology, genetic code expansion of Trp analogues for solution NMR studies 🇨🇦🇨🇦 PhD student | University of Toronto | Biological chemistry

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Reposted by Phil Drewniak
Stephan Hacker @stephanhacker2.bsky.social · 11/12/2025
Interesting paper by the groups of @zhizhou1619.bsky.social and Xiang Sheng in @natcomms.nature.com. They developed a system, with which thiophenols can be fed to cells, converted into non-canonical amino acids and used for genetic code expansion in protein engineering.
nature.com
Design and evolution of artificial enzyme with in-situ biosynthesized non-canonical amino acid
Nature Communications - Enzyme design with non-canonical amino acids has achieved rapid progress in biocatalysis. Here, the authors present an efficient strategy for the design of artificial...
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Reposted by Phil Drewniak
Dreamcatcher @dreamcatcher01.bsky.social · 15/04/2025
Eastern Bluebird Sometimes you have to pause in order to appreciate...
A blue and tan male Eastern Bluebird is poised on the side of a tree.
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Phil Drewniak @lostmydeuteron.bsky.social · 08/04/2025
A little late but wanted to highlight some work during my master's. If you're interested in aquaporins or hydrogen-bonded networks within proteins, take a look :) A conserved H-bond network in human aquaporin-1 is necessary for native folding and oligomerization: www.cell.com/biophysj/ful...
cell.com
A conserved H-bond network in human aquaporin-1 is necessary for native folding and oligomerization
Aquaporins (AQPs) are α-helical transmembrane proteins that conduct water through membranes with high selectivity and permeability. For human AQP1, in addition to the functional Asn-Pro-Ala motifs and...
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Reposted by Phil Drewniak
Derek Lowe @dereklowe.bsky.social · 05/03/2025
Another “Continuing Crisis” post, this one covering some larger principles and explaining why I’m doing these in general:
science.org
The Continuing Crisis, Part VII: An Overview
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Reposted by Phil Drewniak
ErrantScience @errantscience.com · 22/12/2024
Not many more days to open, I hope you've all finished purifying your products from door 16 to mix with the product of door 22
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Phil Drewniak @lostmydeuteron.bsky.social · 11/12/2024
Undeniably cool. Definitely has large implications for life on other planets - namely Mars and even the moons of Jupiter and Saturn etc.
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Reposted by Phil Drewniak
estella newcombe @estellaan.bsky.social · 27/11/2024
We did this crazy project where we tried to see if proteins could interact with their mirror image ligand. Seems impossible when proteins need to form 3D structures to interact. But what about if the interaction remains disordered??? www.nature.com/articles/s41...
nature.com
Stereochemistry in the disorder–order continuum of protein interactions - Nature
Studies on protein–protein interactions using proteins containing d- or l-amino acids show that stereoselectivity of binding varies with the degree of disorder within the complex.
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Reposted by Phil Drewniak
César Sánchez @twistedbacteria.bsky.social · 29/11/2024
All cells are encapsulated by a membrane of complex lipidic composition, right? Not anymore! @JamesSaenz.bsky.social et al. show that a ‘minimal’ bacterial cell only needs 2 lipid species #microNatComms #Microbiology #CellBiology #lipids Read the paper: www.nature.com/artic...
nature.com
A tuneable minimal cell membrane reveals that two lipid species suffice for life
Nature Communications - All cells are encapsulated by a membrane of complex lipidic composition, and understanding the roles of different lipids in membrane function is experimentally challenging...
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Reposted by Phil Drewniak
Anj of Garigal @garigalanj.bsky.social · 29/11/2024
On the bright side about fire ant venom: 'Derivatives of solenopsins, (fire ant potent piperidine alkaloids), have been found to have antibacterial, antifungal, insecticidal, and antiangiogenics activities' (article about the Thai fire ant Solenopsis geminata) pmc.ncbi.nlm.nih.gov/articles/PMC...
Molecular docking of the endogenous ligands binding at different Sol g 2.1 model binding sites. (A–D) Show the top ranks of binding sites, including internal (site 1) and external (site 2–3) binding sites in the Sol g 2.1 protein model, which were contacted with the ligands. Decane, undecane, dodecane, and tridecane ligands were represented as yellow, green, cyan, and dark gray colored sticks, respectively. (E) The top rank of the lowest S score of each ligand at the three binding sites, triplicate (S score mean ± SEM).
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Reposted by Phil Drewniak
Jump Cat @jumpcatt.bsky.social · 19/11/2024
this is a cow
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