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loschmidtlab.bsky.social

@loschmidtlab.bsky.social
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loschmidtlab.bsky.social @loschmidtlab.bsky.social · 02/10/2026
🧬 Great discussions at our joint workshop with MSD Animal Health! Experts shared insights on biotherapeutics and protein stabilization, while Loschmidt Labs showcased computational protein design and microfluidic screening. Thanks to everyone involved! 🙌 #CLARA
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loschmidtlab.bsky.social @loschmidtlab.bsky.social · 01/10/2026
New article published in 𝗔𝗖𝗦 𝗖𝗮𝘁𝗮𝗹𝘆𝘀𝗶𝘀! 📢🧬 In our latest study, we introduced Brnoteplase, a promising new thrombolytic candidate, while demonstrating the impact of multiobjective enzyme engineering in overcoming trade-offs in therapeutic protein design. 🧠🩸 pubs.acs.org/accacs/artic...
pubs.acs.org
Multiobjective Engineering of Fibrin-Selective Thrombolytic Proteases with Enhanced Biocatalytic Efficiency and Inhibition Resistance
AbstractThrombolytic enzymes represent an important class of proteolytic biocatalysts for medical applications, yet currently used FDA-approved variants, i
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loschmidtlab.bsky.social @loschmidtlab.bsky.social · 25/09/2026
We celebrated our new ACS Catalysis paper, "𝗨𝗻𝗰𝗼𝘃𝗲𝗿𝗶𝗻𝗴 𝗙𝘂𝗻𝗰𝘁𝗶𝗼𝗻𝗮𝗹 𝗗𝗶𝘀𝘁𝗮𝗻𝘁 𝗠𝘂𝘁𝗮𝘁𝗶𝗼𝗻𝘀 𝗯𝘆 𝗨𝗹𝘁𝗿𝗮-𝗛𝗶𝗴𝗵-𝗧𝗵𝗿𝗼𝘂𝗴𝗵𝗽𝘂𝘁 𝗦𝗰𝗿𝗲𝗲𝗻𝗶𝗻𝗴 𝗼𝗳 𝗗𝗲𝗵𝗮𝗹𝗼𝗴𝗲𝗻𝗮𝘀𝗲𝘀"! 🧪 Lead author Hana Faldynova highlighted this 10-year effort by 30 co-authors. Congrats to all! 👏 #ACSCatalysis #Biology #Biochemistry #uHTS #Enzymology
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loschmidtlab.bsky.social @loschmidtlab.bsky.social · 24/09/2026
Our team attended the 7th #EnzymeML Workshop in Rüdesheim, Germany. PhD student Martin Richter presented his work on resolving enzymatic mechanisms from ligand-binding data using machine learning. Great discussions and inspiring atmosphere! 🤝 #MachineLearning #Enzymology #CLARA
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loschmidtlab.bsky.social @loschmidtlab.bsky.social · 23/09/2026
It was a pleasure hosting 𝗡𝗶𝗸𝗶𝘁𝗮𝘀 𝗚𝗲𝗼𝗿𝗴𝗶𝗼𝘂 (Center for Interdisciplinary Biosciences, Kosice) at Loschmidt Laboratories! His 2-week exchange focused on protein engineering and computational study of AChE/BChE in neurodegenerative disorders. Thanks to COZYME COST Action CA21162 for supporting us!
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loschmidtlab.bsky.social @loschmidtlab.bsky.social · 17/09/2026
Our new paper on 𝗙𝗶𝗿𝗲𝗣𝗿𝗼𝘁𝗔𝗦𝗥 𝟮.𝟬 is out in 𝗕𝗿𝗶𝗲𝗳𝗶𝗻𝗴𝘀 𝗶𝗻 𝗕𝗶𝗼𝗶𝗻𝗳𝗼𝗿𝗺𝗮𝘁𝗶𝗰𝘀! 🧬📖 Engineered for evolution-guided protein design, it combines ancestral sequence reconstruction with future mutation prediction & generative VAEs in one web tool. Try it here: loschmidt.chemi.muni.cz/fireprotasr/
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loschmidtlab.bsky.social @loschmidtlab.bsky.social · 15/09/2026
Our PhD student Martin Sitte joined the 𝗖𝗖𝗣𝟰-𝗕𝗖𝗔 𝗣𝗿𝗼𝘁𝗲𝗶𝗻 𝗖𝗿𝘆𝘀𝘁𝗮𝗹𝗹𝗼𝗴𝗿𝗮𝗽𝗵𝘆 𝗦𝘂𝗺𝗺𝗲𝗿 𝗦𝗰𝗵𝗼𝗼𝗹 in Norwich for advanced crystallography training. “An intense, challenging, and fun week!” says Martin, who now heads to Yeshiva University in NYC. Safe travels!
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loschmidtlab.bsky.social @loschmidtlab.bsky.social · 11/09/2026
In just a few days, we’re opening registration for our 𝗛𝗮𝗻𝗱𝘀‑𝗼𝗻 𝗖𝗼𝗺𝗽𝘂𝘁𝗮𝘁𝗶𝗼𝗻𝗮𝗹 𝗘𝗻𝘇𝘆𝗺𝗲 𝗗𝗲𝘀𝗶𝗴𝗻 𝗖𝗼𝘂𝗿𝘀𝗲— a training event for anyone looking to advance their skills in protein engineering. 🚀 Seats fill up fast every year, so make sure to secure yours as soon as registration goes live! 🔬
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loschmidtlab.bsky.social @loschmidtlab.bsky.social · 10/09/2026
Karen at ECCB 2026! 🎉🇨🇭 Karen Pailozian presented TmProt 1.0, a fast ML tool that helps researchers identify and rank stable proteins for experiments. Supported by Horizon Europe #CLARA 🤝
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loschmidtlab.bsky.social @loschmidtlab.bsky.social · 08/09/2026
𝗦𝗰𝗶𝗲𝗻𝗰𝗲 & 𝗧𝗲𝗰𝗵𝗻𝗼𝗹𝗼𝗴𝘆 𝗙𝗲𝘀𝘁𝗶𝘃𝗮𝗹 wrapped up! Thanks to everyone who visited our booth — we explored brain health, early signs of stroke, and tried fun hands‑on activities. Grateful to ICRC and Horizon Europe #CLARA for the support. 🔬🧠✨ #Science #BrainHealth #StrokeAwareness #ICRC #HorizonEurope
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loschmidtlab.bsky.social @loschmidtlab.bsky.social · 03/09/2026
Everything’s packed and ready! Join us tomorrow at the 𝗦𝗰𝗶𝗲𝗻𝗰𝗲 𝗙𝗲𝘀𝘁𝗶𝘃𝗮𝗹 at Brno Exhibition Center, Pavilion A2. We’ll showcase our Alzheimer’s and stroke research, including the molecular models we work with. 🔬🧠 We look forward to seeing you! 📸 Irena Halikova
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loschmidtlab.bsky.social @loschmidtlab.bsky.social · 19/08/2026
❗Pozor, změna termínu❗ 🗓️2. - 3. 9. 2026
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loschmidtlab.bsky.social @loschmidtlab.bsky.social · 14/08/2026
Our PhD student 𝗔𝗹𝗶𝗮𝗸𝘀𝗮𝗻𝗱𝗿𝗮 𝗞𝘂𝗿𝘀𝗶𝘁 presented at #AAIC2026 in London! 🧠🇬🇧 Her research identified existing drugs that bind to ApoE4, with 2 compounds successfully blocking its toxic clumping—a promising step toward new Alzheimer’s therapies. 🔬✨ #Alzheimers #Neuroscience #DrugDiscovery
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loschmidtlab.bsky.social @loschmidtlab.bsky.social · 13/08/2026
Great hosting Abdulkadir Yayci (Ruhr-Universität Bochum) at Loschmidt Labs! 🧪 He spent 3 weeks working with our computational protein engineering tools, & we can't wait to share the results! 🚀 Thanks to COZYME - COST action CA21162 for funding research exchanges like this. 🤝 #ProteinEngineering
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loschmidtlab.bsky.social @loschmidtlab.bsky.social · 12/08/2026
Yesterday, we gathered for our summer barbecue! 🌭🧀 Great food, but even better company and conversations. It was a wonderful opportunity to celebrate our research interns, Rehmadanta Sitepu & Abdulkadir Yayci, as their stay comes to an end.☀️ 📸 Sarka Nevolova
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loschmidtlab.bsky.social @loschmidtlab.bsky.social · 11/08/2026
🔗 Registrace: altium.net/cz/udalost/p...
altium.net
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loschmidtlab.bsky.social @loschmidtlab.bsky.social · 11/08/2026
Využíváte analýzu interakcí biomolekul? Srdečně Vás zveme na seminář k představení přístroje 𝗥𝗲𝘃𝗼 (Nicoya) využívajícího technologii povrchové plazmonové rezonance (SPR). Čeká Vás úvod do metody, ukázka přístroje i hands-on část. 📍 Kdy a kde: 1.–3. 9. 2026, Univerzitní kampus, Brno-Bohunice
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loschmidtlab.bsky.social @loschmidtlab.bsky.social · 10/08/2026
Ready to take your enzyme engineering skills to the next level? 🧬 Registration opens 𝗦𝗲𝗽𝘁𝗲𝗺𝗯𝗲𝗿 𝟭𝟲, 𝟮𝟬𝟮𝟲 for our 8th Hands-on Computational Enzyme Design Course! 🚀 ⏳Early-bird discounts apply! Don't miss out. 📍Learn more here: loschmidt.chemi.muni.cz/academy/
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loschmidtlab.bsky.social @loschmidtlab.bsky.social · 07/08/2026
Big congratulations to 𝗗𝗮𝘃𝗶𝗱 𝗛𝗮𝗿𝗱𝗶𝗻𝗴-𝗟𝗮𝗿𝘀𝗲𝗻 (DTU Biosustain) on successfully defending his PhD thesis on machine learning for enzyme development, co-supervised by our Stanislav Mazurenko! 🎓✨ It was a pleasure hosting David at Loschmidt Labs. Wish you all the best next! 🧪🧬
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loschmidtlab.bsky.social @loschmidtlab.bsky.social · 05/08/2026
Máš vystudovanou přírodovědu a láká tě výzkum, který má reálný dopad na léčbu rakoviny? 🔬 Do proteomické laboratoře naší spolupracovnice Lenky Hernychové na Masarykově onkologickém ústavu v Brně hledají aktuálně novou kolegyni/kolegu na pozici Výzkumný pracovník junior! 🧪 www.mou.cz/vyzkumny-pra...
mou.cz
Výzkumný pracovník - vhodné pro absolventy VŠ / Masarykův onkologický ústav Brno
Pracovní nabídka v MOÚ.
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loschmidtlab.bsky.social @loschmidtlab.bsky.social · 20/07/2026
On Friday, we celebrated the acceptance of our FireProt ASR 2.0 manuscript in Briefings in Bioinformatics and the award of a new GAČR grant supporting our collaboration with Aleksandra Marsavelski's team.🥂 📷 Irena Halikova
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loschmidtlab.bsky.social @loschmidtlab.bsky.social · 17/07/2026
Our team member, 𝗦𝗲𝗿𝗴𝗶𝗼 𝗠𝗮𝗿𝗾𝘂𝗲𝘀, attended the conference Quitel 2026 in Coimbra, Portugal, last week! Sergio presented our work on CAVER, CaverDock, and Caver Web in an invited plenary lecture and an oral presentation, highlighting their applications in protein tunnel analysis and ligand transport.
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loschmidtlab.bsky.social @loschmidtlab.bsky.social · 16/07/2026
Summer barbecue at Loschmidt Laboratories! 🍔🔥 A big thank you to Irena Halikova and everyone involved in organizing this wonderful event! We enjoyed delicious food, refreshing drinks, and great conversations with colleagues. 📷 Karolina Sedlackova
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loschmidtlab.bsky.social @loschmidtlab.bsky.social · 25/06/2026
We were pleased to welcome 𝗔𝗹𝗲𝗸𝘀𝗮𝗻𝗱𝗿𝗮 𝗠𝗮𝗿𝘀𝗮𝘃𝗲𝗹𝘀𝗸𝗶 from the University of Zagreb for 𝗙𝗮𝗿𝗮𝗻𝗲𝗵 𝗛𝗮𝗱𝗱𝗮𝗱𝗶’s defense and to show her around our lovely city of Brno. Thank you for your visit, Aleksandra! We look forward to many more opportunities to work together.🤝✨ 📸 Stanislav Mazurenko
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loschmidtlab.bsky.social @loschmidtlab.bsky.social · 24/06/2026
The names of our newest PhD graduates have appeared on the "Walk of Fame" in front of the red Campus building. ✨ We are proud of their achievements and wish them all the best on their next journey! 🚀
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loschmidtlab.bsky.social @loschmidtlab.bsky.social · 23/06/2026
🎓 Congratulations to 𝗣𝗮𝘃𝗲𝗹 𝗞𝗼𝗵𝗼𝘂𝘁 on the successful defense of his PhD thesis, Machine Learning for Computational Protein Design, at @recetox.bsky.social, Masaryk University! His work applies state-of-the-art ML to protein engineering. #PhD #MachineLearning #ProteinEngineering
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loschmidtlab.bsky.social @loschmidtlab.bsky.social · 22/06/2026
🏆 Congratulations to our doctoral students! At the @recetox.bsky.social 𝗗𝗼𝗰𝘁𝗼𝗿𝗮𝗹 𝗖𝗼𝗻𝗳𝗲𝗿𝗲𝗻𝗰𝗲 𝟮𝟬𝟮𝟲, Daniel Pluskal's poster on engineering Renilla reniformis GFP ranked among the top three posters, and Martin Sitte successfully passed his doctoral state examination.🎓👏
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loschmidtlab.bsky.social @loschmidtlab.bsky.social · 19/06/2026
🏆 Success for high school students at Loschmidt Laboratories! Monika Dlouhá won 🥈 2nd place and Amálie Steklá 🥉 3rd place in Molecular Biology at the national SOČ competition in Olomouc. Congratulations to the students and their supervisors! 👏🔬 #MolecularBiology #STEM #YoungScientists #SOC
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loschmidtlab.bsky.social @loschmidtlab.bsky.social · 17/06/2026
Summer Starts with Beach Volleyball! 🏐☀️ The first beach volleyball match of the summer took place this Monday, bringing together players from Pavel Dvořák’s Microbial Bioengineering Laboratory and the Loschmidt Laboratories. Many thanks to Martin Sitte for organizing this event!
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loschmidtlab.bsky.social @loschmidtlab.bsky.social · 16/06/2026
🔥 Last Friday, we celebrated a major milestone as 𝗙𝗮𝗿𝗮𝗻𝗲𝗵 𝗛𝗮𝗱𝗱𝗮𝗱𝗶 and 𝗝𝗮𝗻 𝗠𝗶𝗰𝗮𝗻 earned their PhDs! Despite the chilly weather, we enjoyed a great BBQ, good conversations, and a toast to their achievements. 🍖🍻 Congratulations and best wishes for the future! ✨🎉 📸 Sarka Nevolova
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loschmidtlab.bsky.social @loschmidtlab.bsky.social · 15/06/2026
🏆 Great success at ISBC & ISLS 2026 in Rayong, Thailand! 🎉 In a highly competitive field, 𝗞𝗮𝗿𝗼𝗹𝗶𝗻𝗮 𝗦𝗲𝗱𝗹𝗮𝗰𝗸𝗼𝘃𝗮 received the Outstanding Poster Presentation Award and 𝗠𝗮𝗿𝘁𝗶𝗻 𝗦𝗶𝘁𝘁𝗲 the Outstanding Oral Presentation Award. 👏 Congratulations to both!
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loschmidtlab.bsky.social @loschmidtlab.bsky.social · 12/06/2026
🔗 www.sci.muni.cz/clanky/ceny-...
sci.muni.cz
Ceny děkana 2026 ocenily mimořádné studijní a vědecké úspěchy i inspirativní pedagogickou práci
Děkan Přírodovědecké fakulty Masarykovy univerzity Luděk Bláha slavnostně předal Ceny děkana za akademický rok 2025/2026 celkem 24 oceněným, kteří svými výsledky a přístupem významně přispívají k rozv...
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loschmidtlab.bsky.social @loschmidtlab.bsky.social · 12/06/2026
🏆 Congratulations to 𝗠𝗮𝗿𝘁𝗶𝗻 𝗛𝗮𝘃𝗹𝗮𝘀𝗲𝗸 of Loschmidt Laboratories on receiving the 𝗗𝗲𝗮𝗻’𝘀 𝗔𝘄𝗮𝗿𝗱 from the Faculty of Science, Masaryk University! During his PhD at @recetox.bsky.social, he develops computational methods for Alzheimer’s disease research.🧠 #Excellence #PhD #Research #AlzheimersDisease
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loschmidtlab.bsky.social @loschmidtlab.bsky.social · 10/06/2026
🔬 Our PhD student Pavel Kohout spent a month at Chalmers University 🇸🇪 in the Zelezniak Lab, exploring whether molecular dynamics and ML-based methods (SAMt, BioEmu, BBFlow) can explain experimental observables. Supported by #CLARA. 📸 Pavel Kohout #ResearchInternship #ComputationalBiology
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loschmidtlab.bsky.social @loschmidtlab.bsky.social · 09/06/2026
🎓 Congratulations to Dr. 𝗙𝗮𝗿𝗮𝗻𝗲𝗵 𝗛𝗮𝗱𝗱𝗮𝗱𝗶 on successfully defending her PhD thesis, Integrating Machine Learning with Structural Protein Analysis! Her work bridged structural biology, ML, and explainable AI, resulting in 3 publications and an invited conference talk. 👏🔬 #PhDDefense #MachineLearning
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loschmidtlab.bsky.social @loschmidtlab.bsky.social · 05/06/2026
Secondary school student Amalie Stekla won three awards at the Conference of Young Life Scientists 2026 for her research on bioluminescence in the brittle star Amphiura filiformis. 🥇 Audience Award 🥇 1st Place (Chemistry–Physics–Informatics) 🌍 Main Prize (100,000 CZK) Congratulations!
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loschmidtlab.bsky.social @loschmidtlab.bsky.social · 04/06/2026
🌐 The server is freely available: loschmidt.chemi.muni.cz/enzymeminer/ 📖 Read the full article: academic.oup.com/nar/advance-...
loschmidt.chemi.muni.cz
EnzymeMiner 2.0 – Automated mining of soluble enzymes with diverse structures, catalytic properties and stabilities
EnzymeMiner identifies putative members of the studied enzyme family and facilitates their prioritization and well-informed selection for experimental characterization to reveal novel biocatalysts.
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loschmidtlab.bsky.social @loschmidtlab.bsky.social · 04/06/2026
🎉 Our paper on EnzymeMiner 2.0 has been accepted in Nucleic Acids Research (@narjournal.bsky.social)! 🔬 The free web server automates enzyme mining and characterization from large protein databases, helping identify promising candidates for experimental testing. #Bioinformatics #Enzymes #NAR
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loschmidtlab.bsky.social @loschmidtlab.bsky.social · 03/06/2026
🎓 Congratulations to 𝗝𝗮𝗻 𝗠𝗶𝗰𝗮𝗻 on earning his PhD! His thesis, Molecular Modeling and Bioinformatics in the Study of Thrombolytics, marked the successful completion of his doctoral studies, which included 13 publications, international research stays, and outstanding scientific achievements. 👏🔬
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loschmidtlab.bsky.social @loschmidtlab.bsky.social · 01/06/2026
Read more here: www.fnusa-icrc.org/en/sticky-no...
fnusa-icrc.org
Sticky No More: New Algorithm Helps Scientists Reduce Protein Aggregation - ICRC - International Clinical Research Center
Proteins are the silent engines of modern life. They help make life-saving medicines, break down environmental pollutants, improve our food, and power industrial processes. Nevertheless, there is a ca...
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loschmidtlab.bsky.social @loschmidtlab.bsky.social · 29/05/2026
🔗 Press release: www.fnusa-icrc.org/cs/uz-zadne-...
fnusa-icrc.org
Už žádné lepení: Nový algoritmus pomáhá vědcům omezit agregaci proteinů - ICRC - International Clinical Research Center
Proteiny jsou tichými motory moderního života. Pomáhají vyrábět život zachraňující léky, rozkládat látky znečišťující životní prostředí, zlepšovat naše potraviny a pohánět průmyslové procesy. Má to vš...
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loschmidtlab.bsky.social @loschmidtlab.bsky.social · 29/05/2026
🧬 Scientists from Loschmidt Laboratories & IT4Innovations developed AggreProt — an AI tool that identifies protein “sticky” regions causing aggregation. Published in Communications Chemistry. Supported by CLARA. 🔬 www.nature.com/articles/s42... #AI #Biotech #ProteinEngineering
nature.com
Experimentally validated deep learning control of protein aggregation - Communications Chemistry
The identification of aggregation-prone regions in proteins and their suppression through mutations is a powerful strategy to enhance protein solubility and yield, expanding their potential applicatio...
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loschmidtlab.bsky.social @loschmidtlab.bsky.social · 26/05/2026
🏆 Congratulations to our team leader, 𝗗𝗮𝘃𝗶𝗱 𝗕𝗲𝗱𝗻𝗮𝗿, on receiving the MU Rector’s Award for Outstanding Research Achievements for Young Scientists Under 40! 🎉👏 🔬 David is a leading expert in protein engineering, molecular modeling & bioinformatics. 📸 Martin Indruch #Science #Research #Excellence
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loschmidtlab.bsky.social @loschmidtlab.bsky.social · 25/05/2026
Congrats to our PhD student Hana Faldynova! 🎉 She won the Student Award for the Best Oral Presentation at the 25th Interdisciplinary Meeting of Young Researchers and Students 2026 in Trest. 🏆 Her talk on ultra-high-throughput screening of dehalogenases received the most audience votes. 👏
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loschmidtlab.bsky.social @loschmidtlab.bsky.social · 22/05/2026
Congratulations to 𝗠𝗮𝗿𝗶𝗸𝗮 𝗠𝗮𝗷𝗲𝗿𝗼𝘃𝗮 on successfully defending her PhD thesis at Masaryk University under the supervision of Martin Marek. 👏 Excellent science, a great defense, and an inspiring example of balancing research with motherhood. 💙🚀 #PhD #WomenInScience #Biochemistry #StructuralBiology
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loschmidtlab.bsky.social @loschmidtlab.bsky.social · 15/05/2026
🥂 Today, we celebrated 6 newly accepted publications, major awards, and the amazing teamwork behind them at the Loschmidt Laboratories. Congrats to all authors and awardees — and thanks to Sergio for marking 13 years at MU with a delicious Marlenka cake. 🍰
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loschmidtlab.bsky.social @loschmidtlab.bsky.social · 13/05/2026
Today’s 𝗠𝗨𝗡𝗜 𝗗𝗮𝘆 at Loschmidt Laboratories featured two guided excursions introducing visitors to proteins, protein engineering, and bacterial protein preparation. Thanks to Martin Havlasek and Magdalena Votapkova for leading the tours! 👏 📸 Sarka Nevolova
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loschmidtlab.bsky.social @loschmidtlab.bsky.social · 07/05/2026
Read the full article here: www.sciencedirect.com/science/arti...
sciencedirect.com
Taurine inhibits apolipoprotein E4 aggregation
Apolipoprotein E4 (ApoE4) is a major genetic risk factor in many neurodegenerative diseases, yet effective therapeutic strategies targeting its associ…
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loschmidtlab.bsky.social @loschmidtlab.bsky.social · 07/05/2026
Our new paper, “Taurine inhibits apolipoprotein E4 aggregation,” has been accepted in Biomedicine & Pharmacotherapy. 🎉📄 We show that taurine reduces ApoE4 aggregation and shifts it toward a less harmful ApoE3-like profile, opening new perspectives for neurodegenerative disease therapies. 🧠🔬
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loschmidtlab.bsky.social @loschmidtlab.bsky.social · 06/05/2026
Our senior researcher Sérgio Marques will give a talk focused on fast computational analysis of protein tunnels at the 49th International Congress of Theoretical Chemists of Latin Expression (𝗤𝘂𝗶𝘁𝗲𝗹 𝟮𝟬𝟮𝟲). The congress will take place in Coimbra, Portugal, from 5–10 July 2026. 🌍🧪
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