Reposted by Lorenzo PenoneRasit Durak @rasitdurak.bsky.social · 20/06/2026Is the rate of protein evolution really constant through time? In our new preprint, we map lineage-specific shifts in evolutionary rates across thousands of protein families spanning the tree of life and explore how evolutionary history and protein structure shape these patterns. Check it out: 032
Reposted by Lorenzo PenoneSungbin Lim @sungbin.bsky.social · 10/06/2026Our new study is now available on @molbioevol.bsky.social Here, we show that the loss of prfB autoregulation might be driven by compensatory evolution rather than direct adaptation of prfB expression. Sometimes, such complex traits can be an 'Evolutionary jail', constraining a species from escaping.l.bsky.socialBluesky 142
Lorenzo Penone @lorenzopenone.bsky.social · 07/12/2025Officially wrapped up my MSc at @unipd.bsky.social! Spent an incredible time exploring compensatory mutations at @mpi-evolbio.bsky.social under the mentorship of @jydutheil.bsky.social. Now, let's see where the fitness landscape leads next. 120
Reposted by Lorenzo PenoneMax Planck Institute for Molecular Genetics @molgen.mpg.de · 08/10/2025New paper! In female mammals, one X-chromosome is inactive in each cell. In some cats, this causes typical color patterns, depending on which X is active and the color it codes for. The @eddaschulz.bsky.social lab found a new regulatory principle behind X-inactivation. 1/2 Note: AI generated image 2227
Lorenzo Penone @lorenzopenone.bsky.social · 21/09/2025My loyalties are split for this year's Ig-Nobel favorite. It's a dead heat between the physicist who analyzed how to stir pasta and the theorist who suggested to eat teflon to reduce calories. Both feel equally essential to the future of humanity. #IgNobel #Science 000
Reposted by Lorenzo PenoneNature @nature.com · 03/09/2025A common type of ant in Europe breaks a fundamental rule in biology: its queens can produce male offspring that are a whole different species go.nature.com/4mOb5T9go.nature.com‘Almost unimaginable’: these ants are different species but share a motherAnt queens of one species clone ants of another to create hybrid workers that do their bidding. 7289128
Lorenzo Penone @lorenzopenone.bsky.social · 19/09/2025Does population size shape protein coevolution? I explored this in my talk today at the MPI for Evolutionary Biology. Our work in mammals suggests the answer is yes - genetic drift is a major determinant of compensatory mutations. #evolution #genomics #proteinevolution @mpi-evolbio.bsky.social 0135
Reposted by Lorenzo PenoneJinyang Liang @jinyangliang.bsky.social · 17/08/2025Please come and see Jinyang’s purr-fectly interesting talk at the #ESEB2025 the coming Thursday 3:45 PM (Meeting Room 116) on Polarizing SNPs without outgroup. (I won’t be there, busy.) -Sent from Naja’s pawphone 063
Lorenzo Penone @lorenzopenone.bsky.social · 11/07/2025Very happy for the chance to share a snapshot of my Master’s project at the MPI for Evolutionary Biology, in Julien Dutheil’s group. I’ve been tracing how the effective population size drives intra-protein compensatory mutations - tiny edits that help life stay in balance. @mpi-evolbio.bsky.social 030