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carriezhu.bsky.social

@carriezhu.bsky.social

Reposted by @carriezhu.bsky.social

Molecular Biology and Evolution @molbioevol.bsky.social · 17/03/2026

@carriezhu.bsky.social , @xliaoyi.bsky.social & @arbelharpak.bsky.social find that inactive X expression levels are a strong linear predictor of female-male expression differences. 🔗 doi.org/10.1093/molb... #evobio #molbio

doi.org

Escape from X inactivation drives sex differences in gene expression

Abstract. X chromosome inactivation (XCI) partially balances gene dosage between sexes; yet, many genes are expressed from the inactive X (Xi) to a variabl

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carriezhu.bsky.social @carriezhu.bsky.social · 17/03/2026

(1/9) Our work (with @xliaoyi.bsky.social @arbelharpak.bsky.social) exploring the role of genes that escape X-chromosome inactivation in shaping the genetic architecture of sex-specific traits is now officially out in Molecular Biology and Evolution! academic.oup.com/mbe/article/...

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carriezhu.bsky.social @carriezhu.bsky.social · 06/08/2025

1/13 In a new preprint, we (with @xliaoyi.bsky.social‬ in the ‪@arbelharpak.bsky.social‬ lab) find that expression from the “inactivated” X (Xi) is consequential for both female-male differences in gene expression and variation among females in disease and physiology: www.biorxiv.org/content/10.1...

biorxiv.org

Escape from X inactivation drives sex differences and female trait variation

X chromosome inactivation (XCI) partially balances gene dosage between sexes, yet expression from the inactive X (Xi) is variable across genes. In this study, we investigate whether gene-level Xi expr...

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