iiinova — where your digital self keeps evolving

Reposted by Longo Lab @ ELSI

Caroline Lynn Kamerlin ☀️ @lynnkamerlin.bsky.social · 16/09/2025

Exploring the role of short peptide motifs (focusing on Walker A P-loop) at the origins of life using simulations. Discussion of collaborative work with the @liamlongo.bsky.social and other colleagues. What can molecular fossils teach us about the first proteins? theconversation.com/molecular-fo...

theconversation.com

Molecular ‘fossils’ offer microscopic clues to the origins of life – but they take care to interpret

A protein historian and evolutionary biochemist found that a protein sequence present across all known life didn’t form as researchers previously thought it did.

084

Longo Lab @ ELSI @liamlongo.bsky.social · 08/09/2025

Representation shapes the questions we ask. Here, we use contrastive learning to unite sequence and structure and build a new, global "map" of protein space. Preprint: www.biorxiv.org/content/10.1... Congratulations to Guy Yanai, who led this work, Rachel Kolodny, Nir Ben Tal, and Gabriel Axel

000

Longo Lab @ ELSI @liamlongo.bsky.social · 21/07/2025

Is phylogenetics the only record of protein history? No! Led by Tatsuya Corlett, we show that the history of enzymes is written into the structure of metabolism. From there, we reconstruct a self-consistent model of metabolic and enzyme evolution. www.biorxiv.org/content/10.1...

biorxiv.org

The History of Enzyme Evolution Embedded in Metabolism

Phylogenetic reconstructions are a primary record of protein evolution. But what other records can attest to the deep history of enzymes, and what tools are needed to decode their meaning? Here, we de...

100

Longo Lab @ ELSI @liamlongo.bsky.social · 30/03/2025

Excited to announce that @preinerin.bsky.social, @colemathis.bsky.social and I were awarded an @hfspo.bsky.social research grant! 🎉 If you are an experimentalist interested in studying protein histories as a graduate student in the Longo Lab ELSI, please get in touch.

262

Reposted by Longo Lab @ ELSI

draganadespotovic.bsky.social @draganadespotovic.bsky.social · 29/03/2025

Our ambidextrous HhH peptide is now in @angewandtechemie.bsky.social Proud of the great team @liamlongo.bsky.social , Metanis lab and Koby Levy lab

031

Longo Lab @ ELSI @liamlongo.bsky.social · 26/03/2025

Need phosphorylating power? Maybe our universal polyphosphate kinase can help! ATP ✅ GTP ✅ CTP ✅ UTP ✅ in vitro transcription ✅ An energizing collaboration with the Matsuura Group @ ELSI. Check out the preprint here👇 www.biorxiv.org/content/10.1...

biorxiv.org

A universal polyphosphate kinase powers in vitro transcription

Polyphosphate kinases (PPKs) catalyze phosphoryl transfer between polyphosphates and nucleotides. Polyphosphates are a cost-effective source of phosphorylating power, making polyphosphate kinases an a...

010