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Lechtenberg Lab

@lechtenberglab.bsky.social
456 followers 163 following 11 posts

The Lechtenberg Lab at WEHI in Melbourne, Australia. Interested in all things ubiquitin, E3 ligases and structural biology.

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Lechtenberg Lab @lechtenberglab.bsky.social · 29/07/2025
We are still accepting abstracts for selected short talks and posters. The abstract deadline has been extended to this Friday, 1st Aug. More information and registration here: www.lorneubiquitin.org .
lorneubiquitin.org
The Australian Ubiquitin Summit 2025
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Lechtenberg Lab @lechtenberglab.bsky.social · 07/07/2025
📣📣 Lorne Ubiquitin – The Australian Ubiquitin Summit 📣📣 20-23 Nov 2025 in Lorne, Australia Join us this Nov for the first ubiquitin meeting in Australia. Submit your abstract by 18 July 2025 for oral and poster presentations: www.lorneubiquitin.org. Please share and repost.
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Lechtenberg Lab @lechtenberglab.bsky.social · 10/04/2025
Excited to share our latest work, now out in @lsajournal.org. we show that the E3 ligase HOIL-1 can ubiquitinate many different saccharides and describe a chemoenzymatic platform to generate ubiquitinated sugars as tools for studying non-proteinaceous ubiquitination.
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Lechtenberg Lab @lechtenberglab.bsky.social · 21/12/2024
For those interested in ubiquitinating their own sugars: our plasmid for bacterial expression of the constitutive HOIL-1 variant is now available via Addgene: www.addgene.org/229539/
addgene.org
Addgene: pOPINB-M1-di-Ub(G76V)-HOIL-1
Plasmid pOPINB-M1-di-Ub(G76V)-HOIL-1 from Dr. Bernhard Lechtenberg's lab contains the inserts Ubiquitin, Ubiquitin, and HOIL-1 and is published in bioRxiv November 30, 2024 This plasmid is available ...
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Reposted by Lechtenberg Lab
bioRxivpreprint @biorxivpreprint.bsky.social · 01/12/2024
The RBR E3 ubiquitin ligase HOIL-1 can ubiquitinate diverse non-proteinaceous substrates in vitro www.biorxiv.org/content/10.1101/202…
biorxiv.org
The RBR E3 ubiquitin ligase HOIL-1 can ubiquitinate diverse non-proteinaceous substrates in vitro https://www.biorxiv.org/content/10.1101/2024.11.29.626046v1
HOIL-1 is a RING-between-RING (RBR)-family E3 ubiquitin ligase and component of the linear ubiquitin
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Lechtenberg Lab @lechtenberglab.bsky.social · 03/12/2024
Excited to share our latest preprint on @biorxivpreprint.bsky.social: "The RBR E3 ubiquitin ligase HOIL-1 can ubiquitinate diverse non-protein substrates in vitro". www.biorxiv.org/content/10.1...
biorxiv.org
The RBR E3 ubiquitin ligase HOIL-1 can ubiquitinate diverse non-protein substrates in vitro
HOIL-1 is a RING-between-RING (RBR)-family E3 ubiquitin ligase and component of the linear ubiquitin chain assembly complex (LUBAC). While most E3 ubiquitin ligases conjugate ubiquitin to protein lysi...
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Reposted by Lechtenberg Lab
Rune Busk Damgaard @rbdamgaard.bsky.social · 15/11/2024
Check out this list of ubiquitin and Ubl profiles to follow. Repost if you want me to add you to it. Let’s create a good community here ☁️ go.bsky.app/3VPQofn
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