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laurenlporter.bsky.social

@laurenlporter.bsky.social
502 followers 70 following 21 posts

Investigates shapeshifting proteins with computation and experiment. Tenure-track. Mother of two. Foodie. Yoga lover. Opinions are mine.

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laurenlporter.bsky.social @laurenlporter.bsky.social · 05/01/2026
Check out Madeleine and Joey's latest work identifying specific amino acid patterns that AlphaFold uses to select protein conformations 🧵 www.biorxiv.org/content/10.6...
biorxiv.org
Explaining how mutations affect AlphaFold predictions
Transformer models, neural networks that learn context by identifying relationships in sequential data, underpin many recent advances in artificial intelligence. Nevertheless, their inner workings are...
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Reposted by @laurenlporter.bsky.social
Gabriel Rocklin @grocklin.bsky.social · 26/03/2025
Small proteins can be more complex than they look! We know proteins fluctuate between different conformations- but by how much? How does it vary from protein to protein? Can highly stable domains have low stability segments? @ajrferrari.bsky.social experimentally tested >5,000 domains to find out!
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Reposted by @laurenlporter.bsky.social
James Fraser @fraserlab.com · 18/02/2025
🚨 New preprint alert! 🚨 How does SARS-CoV-2 use as much of its genome as possible to evade our immune response? Our latest study dissects how Orf9b, which is encoded in an alternate reading frame from the N(ucleocapsid) protein, can regulate interferon signaling. www.biorxiv.org/content/10.1... 🧵👇
biorxiv.org
Coupled equilibria of dimerization and lipid binding modulate SARS Cov 2 Orf9b interactions and interferon response
Open Reading Frame 9b (Orf9b), an accessory protein of SARS-CoV and -2, is involved in innate immune suppression through its binding to the mitochondrial receptor Translocase of Outer Membrane 70 (Tom...
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laurenlporter.bsky.social @laurenlporter.bsky.social · 06/01/2025
Our latest review is out in Current Opinion: Proteins with alternative folds reveal blind spots in AlphaFold-based protein structure prediction www.sciencedirect.com/science/arti...
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laurenlporter.bsky.social @laurenlporter.bsky.social · 14/12/2023
Our latest @bioRxiv manuscript reports an assessment of >500,000 AF2-based predictions of fold-switching proteins, which assume two distinct stable structures. These predictions fail to reflect observed energetics of fold switching 🧵 www.biorxiv.org/content/10.1...
biorxiv.org
AlphaFold2 has more to learn about protein energy landscapes
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
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