iiinova — where your digital self keeps evolving

labmoons.bsky.social @labmoons.bsky.social · 26/09/2026

We won’t be able to make it this year, unfortunately! Hopefully we can make it to the next one! 😊 Have a great time at the conference!

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labmoons.bsky.social @labmoons.bsky.social · 26/09/2026

Our #preprint out on @biorxiv-neursci.bsky.social! 🥳🥳 Using the #killifish optic nerve, we show that #aging alone is sufficient to trigger the emergence of #interferon-responsive #oligodendrocytes, a cell state shared with neurodegenerative and demyelinating diseases. www.biorxiv.org/content/10.6...

biorxiv.org

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Reposted by @labmoons.bsky.social

bioRxiv Neuroscience @biorxiv-neursci.bsky.social · 25/09/2026

An evolutionarily conserved interferon-responsive oligodendroglial state emerges during white matter aging www.biorxiv.org/content/10.64898/20…

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labmoons.bsky.social @labmoons.bsky.social · 29/04/2026

Don't miss this amazing meeting in Austria!!! Deadline to register is May 20, 2026! #EMBORegeneration2026

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labmoons.bsky.social @labmoons.bsky.social · 19/02/2026

To reduce the extensive scarring, we performed a partial optic nerve transection in young adults, leaving a portion of the nerve uninjured. This approach indeed limited scar formation, and it allowed regenerating axons to reach the brain and reinnervate their targets. ✅

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labmoons.bsky.social @labmoons.bsky.social · 19/02/2026

Why does this happen? 🔎 A gliofibrotic scar forms at the injury site, an injury response typically associated with mammals. So the axons keep growing, but they physically and chemically can’t overcome the barrier. The result: permanent vision loss.

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labmoons.bsky.social @labmoons.bsky.social · 19/02/2026

Even more intriguing: the retinal ganglion cells in killifish retain their intrinsic growth potential. 🧐 However, instead of navigating towards the brain, they misdirect and loop within the retina (yellow arrowheads).

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labmoons.bsky.social @labmoons.bsky.social · 19/02/2026

Adult killifish — both young and old — fail to reinnervate their brain target after complete optic nerve transection. 🐠🧠👁️ This is surprising, as most teleost fish are able to fully restore neural circuitry and regain visual function after this type of injury.

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labmoons.bsky.social @labmoons.bsky.social · 16/02/2026

A new preprint from our lab is out! 🥳 Congrats to Anyi Zhang and @lucamasin.bsky.social for this great paper titled: Repressed mTORC1 signaling and transient dendritic pruning support axonal regeneration! Grateful for the fruitful collaboration with the @filodelbene.bsky.social and Poulain labs!

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Reposted by @labmoons.bsky.social

Journal of Cell Biology @jcb.org · 14/11/2025

With transcriptomic and functional data, @lucamasin.bsky.social et al. @labmoons.bsky.social show that local glycolysis supports injury-induced axonal regeneration. rupress.org/jcb/article/... 📕 In Cellular Neurobiology collection: rupress.org/jcb/collecti... #SfN25

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labmoons.bsky.social @labmoons.bsky.social · 21/05/2025

All these data were generated by an updated version of RGCode, RGCode2. An automated cell counting platform able to reliable count murine, zebrafish and killifish retinal ganglion cells using RBPMS and Rbpms2 as marker!

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labmoons.bsky.social @labmoons.bsky.social · 21/05/2025

Killifish, a gerontology model shown to lose its regenerative capacity with age, displays a unique biphasic RGC loss profile. Both young adult and old killifish present with a similar degree of RGC loss during the first wave. Old fish, however, lose more RGCs during the second wave.

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labmoons.bsky.social @labmoons.bsky.social · 21/05/2025

After optic nerve crush (ONC), mice lose ~80% of their RGC by 14 days post injury (dpi). In contract, zebrafish retain nearly all RGC during the first two weeks, before presenting with late RGC degeneration (~13%) by 21dpi.

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labmoons.bsky.social @labmoons.bsky.social · 21/05/2025

Comparing mice, zebrafish and killifish, we were able to determine the differences in retinal ganglion cell (RGC) density between species. Fish species of an equivalent life stage have a five-fold higher density compared to mice. With age, RGC density decreases in killifish.

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Reposted by @labmoons.bsky.social

Leibniz-Institut für Alternsforschung - Fritz-Lipmann-Institut @leibnizfli.bsky.social · 22/04/2025

🐟 2025 Nothobranchius Symposium – End of the registration coming soon Be part of #Notho25 in beautiful #Jena, Germany from June 5-6, 2025 to share the latest in #killifish #aging #research. 🚨 Registration deadline: May 1, 2025 ➡️ Website & registration: notho-2025.de

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