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Kyle Cottrell

@kylecottrell.bsky.social
1.3K followers 167 following 121 posts

Father | Assistant Professor @PurdueBiochem (RNA editing and regulation) | Postdoc & PhD @WUSTL | MS & BS @MissouriState | #firstgen #NewPI #NIHMOSAIC K99/R00 (posts and comments are my own and do not reflect my employer)

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Reposted by Kyle Cottrell
Purdue RNA Club @purduernaclub.bsky.social · 04/09/2026
It's a new year and the Purdue RNA Club is back! Mark your calendars as we will be meeting September 11, October 2, 2026, November 6 and December 4, all 3:30-4:30 in ABE B061.
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Kyle Cottrell @kylecottrell.bsky.social · 24/05/2026
Switch to natives and you get beautiful blooms and pollinators.
Swallowtail on coneflowersBlue flag iris and spiderwort flowers.
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Kyle Cottrell @kylecottrell.bsky.social · 16/05/2026
This week the lab said goodbye to three undergraduate researchers. Estelle was the first person to join the lab. Renee and Madison joined not long after. Each have made important contributions leading to authorships. They are now off to dental, medical and graduate school! We will miss them greatly.
Renee, Madison and Estelle with their carved pumpkins.
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Reposted by Kyle Cottrell
Purdue RNA Club @purduernaclub.bsky.social · 01/05/2026
Today is the day! Our first Purdue RNA Club Symposium. Thanks to support from @rnasociety.bsky.social and #Lexogen.
The symposium program. Posters, lunch, trainee talks and keynote from Craig Pikaard.
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Reposted by Kyle Cottrell
Jacki Heraud-Farlow @jackiheraudfarlow.bsky.social · 06/02/2026
I’m super excited to be opening a lab at WEHI. We’ll be focussing on how double-stranded RNA is regulated in cells, how failures in these pathways drive disease and new therapies to manipulate inflammatory responses to RNA. #newPI #RNAsky
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Kyle Cottrell @kylecottrell.bsky.social · 03/02/2026
I wonder who gets spots in the Purdue summer camp before us plebs gets our chance to register? Must be nice to have a guaranteed spot and not have to block out your morning and stress over getting a good spot in the registration queue.
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Kyle Cottrell @kylecottrell.bsky.social · 20/01/2026
Fuck.
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Kyle Cottrell @kylecottrell.bsky.social · 02/01/2026
Some us, not very many, started at community college and never took the ACT or SAT...
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Kyle Cottrell @kylecottrell.bsky.social · 25/12/2025
Per tradition, the house has been built. Decorations tomorrow!
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Kyle Cottrell @kylecottrell.bsky.social · 11/12/2025
Done with the last lecture of the year! Looking forward to the next ~9 months of bench work.
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Kyle Cottrell @kylecottrell.bsky.social · 27/11/2025
New addition this year was homemade cranberry sauce. Don't know why I waited this long to do that on.
Thanksgiving dinner, turkey, sweet potatoes, mashed potatoes, stuffing, cranberry sauce, rolls, gravyRoasted spatchcocked turkey
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Kyle Cottrell @kylecottrell.bsky.social · 23/11/2025
Almost made it to Thanksgiving.
Green onions, carrots and some cilantro.
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Kyle Cottrell @kylecottrell.bsky.social · 15/11/2025
Meme voicing displeasure with writing the 'innovation' section of a grant proposal.
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Kyle Cottrell @kylecottrell.bsky.social · 28/10/2025
We start the module on nerve gasses in my course today - queue Nick Cage!
media.tenor.com
a man is kneeling down with his arms outstretched in front of a body of water with a bridge in the background
ALT: a man is kneeling down with his arms outstretched in front of a body of water with a bridge in the background
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Kyle Cottrell @kylecottrell.bsky.social · 17/10/2025
Well, I'm going to find out, eventually.
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Reposted by Kyle Cottrell
Purdue RNA Club @purduernaclub.bsky.social · 06/10/2025
RNA Club returns on Friday with Iman Mevaa from the @kasinskilab.bsky.social presenting a talk titled Targeted Delivery of Tumor-Suppressive miR-34a for Osteosarcoma Treatment. We will meet in ABE B061 at 3:30 on October 10.
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Kyle Cottrell @kylecottrell.bsky.social · 05/10/2025
My first trip out of the Purdue Airport went... well, it didn't. I ended up on the shuttle to ORD anyway. It could be great to fly out of LAF, but there probably needs to be more volume to make it reliable.
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Kyle Cottrell @kylecottrell.bsky.social · 26/09/2025
Important aster update!
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Kyle Cottrell @kylecottrell.bsky.social · 24/09/2025
How are we supposed to advise undergraduates interested in applying to graduate school soon? They are scared that their options will be limited. They don't know if it is better to rush to get in or wait until things maybe get better. They don't have as many options for post-bacc programs. It's rough
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Kyle Cottrell @kylecottrell.bsky.social · 18/09/2025
This preprint was accepted @rnajournal.bsky.social! It is now online ahead of print! @cancer-inst-purdue.bsky.social @purduernaclub.bsky.social rnajournal.cshlp.org/content/earl...
rnajournal.cshlp.org
ZYS-1 is not an ADAR1 inhibitor
A monthly journal publishing high-quality, peer-reviewed research on all topics related to RNA and its metabolism in all organisms
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Kyle Cottrell @kylecottrell.bsky.social · 08/09/2025
Patience was rewarded. Wonderfully set and no soggy bottom.
Apple pie profile Apple pie bottom.
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Kyle Cottrell @kylecottrell.bsky.social · 07/09/2025
What to do while you wait for the apple pie to cool? Eat the mini pie you made with the extra pastry, of course. This hack brought to you by my grandma.
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Kyle Cottrell @kylecottrell.bsky.social · 29/08/2025
The fall bloomers are starting to make an appearance! Skip the mums, plant asters!
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Reposted by Kyle Cottrell
Purdue RNA Club @purduernaclub.bsky.social · 26/08/2025
Welcome to the bsky account for the Purdue RNA Club! Our meeting dates for Fall 2025 are September 12, October 10, November 14, and December 5.
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Kyle Cottrell @kylecottrell.bsky.social · 25/08/2025
Anyone in the West Lafayette area have an explanation for why they closed the right lane of River Road here? It's closed for maybe 200 ft. I think that they did this either to intentionally make traffic worse or to further aggravate the businesses that didn't sell their land.
Road closure on River Road.
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Kyle Cottrell @kylecottrell.bsky.social · 18/08/2025
I might need to dial back the jalapeños for the next batch. 🔥🔥
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Kyle Cottrell @kylecottrell.bsky.social · 17/08/2025
Our tomatillos finally started producing!
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Kyle Cottrell @kylecottrell.bsky.social · 14/08/2025
This manuscript was accepted @rnajournal.bsky.social and is online ahead of publication now! Congratulations to first author Addison Young and all the co-authors (for several this is their first publication). @cancer-inst-purdue.bsky.social 1/2 rnajournal.cshlp.org/content/earl...
rnajournal.cshlp.org
PACT suppresses PKR activation through dsRNA binding and dimerization, and is a therapeutic target for triple-negative breast cancer
A monthly journal publishing high-quality, peer-reviewed research on all topics related to RNA and its metabolism in all organisms
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Kyle Cottrell @kylecottrell.bsky.social · 13/08/2025
Here is the post thread I promised: We have been interested in ADAR1 as a therapeutic target for triple-negative breast cancer for a while. That project was supported by the NIH before Trump terminated it, but that is another story. While ADAR1 is a promising target - there aren't any inhibitors 1/n
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Kyle Cottrell @kylecottrell.bsky.social · 09/08/2025
Our second preprint is out today! Post thread to come later.
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Kyle Cottrell @kylecottrell.bsky.social · 02/08/2025
So, when this gets packaged into an exosome, is it a virus? I'm only being a little sarcastic.
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Kyle Cottrell @kylecottrell.bsky.social · 25/07/2025
A moment of beauty in the garden provides a brief distraction from the slow death of science in this country.
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Kyle Cottrell @kylecottrell.bsky.social · 23/07/2025
I wonder if tenure committees and university administration will consider this when making tenure/promotion decisions?
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Kyle Cottrell @kylecottrell.bsky.social · 18/07/2025
This is terrible, and unfortunately, based on my experience sharing this information with others, many in academia (especially more senior faculty) aren't even aware of this change.
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Kyle Cottrell @kylecottrell.bsky.social · 02/06/2025
I treated the lab to a trip to the San Diego Zoo to celebrate our first preprint and for the members attending their first conference, surviving #RNA25. While the zoo is famous for the pandas, the koalas were my favorite!
Cottrell Lab in front of a panda sign at San Diego Zoo.
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Kyle Cottrell @kylecottrell.bsky.social · 30/05/2025
This evening, the newest Cottrell Lab graduate student, Cassandra Smoak, will be presenting poster 402. Over the last few months she has been evaluating a recently published ADAR1 inhibitor - ZYS-1. I'll let her tell you if it is a good inhibitor or not... #RNA25
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Kyle Cottrell @kylecottrell.bsky.social · 29/05/2025
Purdue Biochemistry and @cancer-inst-purdue.bsky.social at #RNA25
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Kyle Cottrell @kylecottrell.bsky.social · 29/05/2025
Just in time for #RNA25, the Cottrell Lab has posted our first independent preprint to bioRxiv. This is the first first-author publication from graduate student Addison Young and the first publication for the four undergraduate co-authors. www.biorxiv.org/content/10.1... 1/n
biorxiv.org
PACT suppresses PKR activation through dsRNA binding and dimerization, and is a therapeutic target for triple-negative breast cancer
Triple-negative breast cancer (TNBC), the deadliest breast cancer subtype, lacks broadly applicable targeted therapies. Induction of viral mimicry by activation of viral double-stranded RNA (dsRNA) se...
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Kyle Cottrell @kylecottrell.bsky.social · 28/05/2025
I haven't had time to make a post thread for this, but if you are at #RNA25, the first-author Addison Young is presenting a poster on this work tonight - P1-108.
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Kyle Cottrell @kylecottrell.bsky.social · 27/05/2025
This is our first preprint! The post thread is coming later today.
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Kyle Cottrell @kylecottrell.bsky.social · 27/05/2025
The Cottrell Lab (minus the undergrads) is on our way to RNA25!
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Kyle Cottrell @kylecottrell.bsky.social · 18/05/2025
If you plant it, they will come.
Monarch on butterfly milkweed.
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Kyle Cottrell @kylecottrell.bsky.social · 11/05/2025
Mother's Day Strawberry Shortcakes and flowers from our garden.
Strawberry shortcakeBouquet of cut flowers, lilac, iris bluebells
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Kyle Cottrell @kylecottrell.bsky.social · 01/05/2025
The dynasty continues. Our third straight IM championship!
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Kyle Cottrell @kylecottrell.bsky.social · 22/04/2025
...but the MRI isn't covered under most plans. It should be covered as a preventative like the mammogram is under the ACA. Shout out to the breast cancer advocates in Indiana that pushed for a state law that requires clinicians to inform patients of breast density. www.hoosierbcadvocates.com/hb-1058
hoosierbcadvocates.com
2024 Legislation | Hoosier Breast Cance
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Kyle Cottrell @kylecottrell.bsky.social · 31/03/2025
The Cottrell lab is in Indy for Pink Out the Statehouse. @cancer-inst-purdue.bsky.social www.hoosierbcadvocates.com/registration...
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Kyle Cottrell @kylecottrell.bsky.social · 11/03/2025
I'm really going to miss Kevin. I've been following him, probably my entire adult life. I mostly gave up political commentary after the 2016 election, but I never stopped reading his blog. If you aren't familiar with Kevin, I suggest you read some of his work on the 'lead crime hypothesis'.
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Kyle Cottrell @kylecottrell.bsky.social · 25/02/2025
I'm glad that study sections will resume soon, but I am furious that the study section for my first R01 application didn't meet today. I'm sure they will be able to quickly reschedule. After all, it should be fairly simple to find a full day for 35 faculty to meet... 1/2
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Kyle Cottrell @kylecottrell.bsky.social · 11/12/2024
Possibly a controversial opinion, but a well informed one as a partent: Mott's fruit snacks are better than Welch's.
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Kyle Cottrell @kylecottrell.bsky.social · 07/12/2024
Really wonder if the university did any traffic studies before they decided to close half the roads on one side of campus.
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