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Kathleen Watt

@kwattever.bsky.social
32 followers 48 following 0 posts

Postdoctoral fellow at Karolinska Institutet / Queen's University | Cancer plasticity, mRNA translation, and all things 5'UTR

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Reposted by Kathleen Watt
Nature Cell Biology @natcellbio.nature.com · 16/11/2025
☕Watt, Dauber, Szkop et al find that H3K4me3 remodels 5′UTR selection in hypoxia and that this process is independent of HIF-1 transcriptional mechanisms. @kwattever.bsky.social @drpostovit.bsky.social @ki.se @queensuhealth.bsky.social bit.ly/47IXjvX
bit.ly
Epigenetic alterations facilitate transcriptional and translational programs in hypoxia - Nature Cell Biology
Watt, Dauber, Szkop and colleagues find that H3K4me3 remodels 5′UTR selection in hypoxia and that this process is independent of HIF-1 transcriptional mechanisms.
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Reposted by Kathleen Watt
Lynne Postovit @drpostovit.bsky.social · 16/10/2025
Our newest paper is out. Here we show that hypoxia induces epigenomic alterations that change where transcripts start. This changes the 5'UTR sequences which then regulate translational efficiency. We think that this is an important regulator of the hypoxic proteome www.nature.com/articles/s41...
nature.com
Epigenetic alterations facilitate transcriptional and translational programs in hypoxia - Nature Cell Biology
Watt, Dauber, Szkop and colleagues find that H3K4me3 remodels 5′UTR selection in hypoxia and that this process is independent of HIF-1 transcriptional mechanisms.
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