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Lynne Postovit

@drpostovit.bsky.social
31 followers 29 following 3 posts
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Reposted by Lynne Postovit
BioTechniques @biotechniques.bsky.social · 01/09/2026
We spoke with @drpostovit.bsky.social – Professor at @queensuglobal.bsky.social – to learn about the techniques and challenges of researching plasticity in cancer progression >>> www.biotechniques.com/cancer-resea... 🧪 #CancerPlasticity #CancerResearch
biotechniques.com
Plasticity in cancer: trying to hit a moving target
In this interview, Lynne-Marie Postovit shares how she investigates cancer plasticity, why it matters and how it could be targeted.
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Reposted by Lynne Postovit
Sinclair Cancer Research Institute @sinclaircri.bsky.social · 19/03/2026
Another captivating @sinclaircri.bsky.social seminar coming up! Dr. Jim Petrik from @uofguelph.bsky.social, hosted by @drpostovit.bsky.social, will be presenting here in #YGK on April 7th at 4 PM. Everyone is welcome to join! @queensuhealth.bsky.social @queensuresearch.bsky.social #cancerresearch
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Lynne Postovit @drpostovit.bsky.social · 16/12/2025
check out our newest preprint showing that #dedifferentiation in certain types of #endometrialcancers may be due to transcriptional chaos rather than cellular reprogramming
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Lynne Postovit @drpostovit.bsky.social · 16/12/2025
www.biorxiv.org/content/10.6...
biorxiv.org
Cell State Chaos Underpins the Evolution of SMARCA4-Deficient Dedifferentiated Endometrial Cancer
Dedifferentiated endometrial carcinoma (DDEC) is a histologically unique cancer type, wherein well-differentiated regions lie adjacent to morphologically distinct, high-grade lesions that are histolog...
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Reposted by Lynne Postovit
Nature Cell Biology @natcellbio.nature.com · 16/11/2025
☕Watt, Dauber, Szkop et al find that H3K4me3 remodels 5′UTR selection in hypoxia and that this process is independent of HIF-1 transcriptional mechanisms. @kwattever.bsky.social @drpostovit.bsky.social @ki.se @queensuhealth.bsky.social bit.ly/47IXjvX
bit.ly
Epigenetic alterations facilitate transcriptional and translational programs in hypoxia - Nature Cell Biology
Watt, Dauber, Szkop and colleagues find that H3K4me3 remodels 5′UTR selection in hypoxia and that this process is independent of HIF-1 transcriptional mechanisms.
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Lynne Postovit @drpostovit.bsky.social · 16/10/2025
Our newest paper is out. Here we show that hypoxia induces epigenomic alterations that change where transcripts start. This changes the 5'UTR sequences which then regulate translational efficiency. We think that this is an important regulator of the hypoxic proteome www.nature.com/articles/s41...
nature.com
Epigenetic alterations facilitate transcriptional and translational programs in hypoxia - Nature Cell Biology
Watt, Dauber, Szkop and colleagues find that H3K4me3 remodels 5′UTR selection in hypoxia and that this process is independent of HIF-1 transcriptional mechanisms.
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