Sign in

Kevin Coombes

@krc77.bsky.social
73 followers 162 following 209 posts

Husband, father, grandfather, cyclist, tifoso, mathematician, biostatistician, bioinformatician. Reader of books, watcher of movies, listener to music, wanderer through museums. Appreciator of foreign travel.

PostsRepliesMedia
Kevin Coombes @krc77.bsky.social · 29/09/2026
Yesterday, I turned 71. Today, my wife and I climbed (on foot) along the porticos from the Arco de Meloncello in Bologna up to the Monisterio di San Luca. Picked out a place to stand during Saturday's Giro dell'Emiglia.
Start of the climb from Bologna to San Luca. The time trial in the 2019 Giro d’Italia used this 180 degree turn.An amateur cyclidt climbing on the way to San Luca. Perhaps a tifoso here early.A view of the climb alongside the porticos.The plaza in front of the Monasterio di San Luca.
021
Kevin Coombes @krc77.bsky.social · 31/07/2026
A former postdoc asked me about "AI scientists", saying they use demographic, clinical, laboratory, and socioeconomic variables to split the same sample set multiple ways. Then perform t-tests on the same gene expression data for each split. How to adjust for multiple testing? #stats #AI 1/n
100
Kevin Coombes @krc77.bsky.social · 17/07/2026
The high-tea Department of War. (Images by Nano Banana.)
000
Kevin Coombes @krc77.bsky.social · 16/03/2026
Title: PLASMA: Partial LeAst Squares for Multiomics Analysis PubMed: pubmed.ncbi.nlm.nih.gov/39858069/ Journal: www.mdpi.com/2072-6694/17... Git: gitlab.com/krcoombes/pl... CRAN: cran.r-project.org/package=plasma
pubmed.ncbi.nlm.nih.gov
PLASMA: Partial LeAst Squares for Multiomics Analysis - PubMed
<span><b>Background/Objectives</b>: Recent growth in the number and applications of high-throughput "omics" technologies has created a need for better methods to integrate multiomics data. Much progress has been made in developing unsupervised methods, but supervised methods have lagged behind. <b>Methods</b></span> …
020
Kevin Coombes @krc77.bsky.social · 16/03/2026
Title: SillyPutty: Improved clustering by optimizing the silhouette width PubMed: pubmed.ncbi.nlm.nih.gov/38848330/ Journal: journals.plos.org/plosone/arti... Git: gitlab.com/krcoombes/si... CRAN: cran.r-project.org/package=Sill...
pubmed.ncbi.nlm.nih.gov
SillyPutty: Improved clustering by optimizing the silhouette width - PubMed
Clustering is an important task in biomedical science, and it is widely believed that different data sets are best clustered using different algorithms. When choosing between clustering algorithms on the same data set, reseachers typically rely on global measures of quality, such as the mean silhoue …
000
Kevin Coombes @krc77.bsky.social · 16/03/2026
Topological Structures in the Space of Treatment-Naïve Patients with Chronic Lymphocytic Leukemia Journal: www.mdpi.com/2072-6694/16... PubMed: pubmed.ncbi.nlm.nih.gov/39123390/ Git: gitlab.com/krcoombes/cl... CRAN: cran.r-project.org/package=RPoi...
pubmed.ncbi.nlm.nih.gov
Topological Structures in the Space of Treatment-Naïve Patients with Chronic Lymphocytic Leukemia - PubMed
Patients are complex and heterogeneous; clinical data sets are complicated by noise, missing data, and the presence of mixed-type data. Using such data sets requires understanding the high-dimensional "space of patients", composed of all measurements that define all relevant phenotypes. The current …
000
Kevin Coombes @krc77.bsky.social · 11/10/2025
Quote of the day from Il Lombardia: @carltonkirby.bsky.social "[some English village] is the best customer for Benedictine liqueur. Do you know why, Brian?" @brismithy.bsky.social "I will know in about 30 seconds."
030
Kevin Coombes @krc77.bsky.social · 05/10/2025
@josebeentv.bsky.social, I'm watching the European men's road championship. You and John keep talking about the tactic of "isolating Pogaĉar". But I can't think of any other rider on the road who is happier riding alone over great distances.
020
Kevin Coombes @krc77.bsky.social · 29/09/2025
Cycling GOATs. Score for measuring cycling greatness: Nine events (3 GT, 5 monuments, road world champ). One point for each win; one point for each kind of event ever won. Top 10: Merckx, 42 Pogacar, 22 Hinault, 21 Coppi, 21 Binda, 18 Gimondi, 17 Van Looy, 16 De Vlaemink, 16 Bartali, 16 Kelly, 15
110
Kevin Coombes @krc77.bsky.social · 03/09/2025
Is there a setting to get Bluesky feeds to move forward in time? Default is to start with newest posts and move backwards. So, you see responses before original posts. I'd like to pick up the steam where I last left it, and move forward.
010
Kevin Coombes @krc77.bsky.social · 27/08/2025
I have a theory that cycling commentators don't actually watch the race. Or maybe it's only Bob Roll and Christian Vande Velde. Stage 3 of the TdF, they didn't mention David Gaudu until he crossed the line. Stage 4, the same with Ben Turner. They only look for things that confirm their expectations.
020
Kevin Coombes @krc77.bsky.social · 09/08/2025
@jezcox.bsky.social There are birds called nutcrackers: Nutcracker (bird) - Wikipedia share.google/yHdK5TdFiFtF...
share.google
Nutcracker (bird) - Wikipedia
010
Kevin Coombes @krc77.bsky.social · 23/07/2025
#stats question: I have data w/3 categorical variables: 3-level copy number (CN) of a gene, 4-level tumor stage, 7-level histology. Both stage and histology are related to copy number, and to each other. Best model/test to see if stage or histo is a more direct driver of CN?
000
Kevin Coombes @krc77.bsky.social · 12/05/2025
@jezcox.bsky.social, I am just watching the replay of Tro Bro Leon. Heard you talking about Breton teams in green. Europcar was one of those in the early 2010's. Started as Bonjour; now TotalEnergies. A couple of years ago, B&B Hotels-KTM was in green and the "team de glaz".
120
Kevin Coombes @krc77.bsky.social · 17/04/2025
@jezcox.bsky.social , while I enjoy your commentary, the mispronunciation of Italian names is grating. "C" before E or I sounds like English ch. That's true of cello and Marcellusi. If you put H between the C and the vowel, it is pronounced hard, like a k. This is true of Chieti and Vecchio.
110
Kevin Coombes @krc77.bsky.social · 09/04/2025
@carltonkirby.bsky.social , While watching the replay of today's stage at the Itzulia, I heard you ask about "Burpellet", a cosponsor of Burgos BH. So, I looked them up. They are a Basque company, SE of Burgos, that manufactures fuel pellets from sawdust and other sawmill residue.
000
Kevin Coombes @krc77.bsky.social · 04/03/2025
@carltonkirby.bsky.social Ename is a Belgian village near Oudenaarde. It's also a beer from a Benedictine monastery brewery with the same name
030