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Kalki Kukreja

@kkukreja.bsky.social
503 followers 222 following 13 posts

Stem cell and devbio scientist

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Reposted by Kalki Kukreja
Krishna Shrinivas @shrinivaslab.bsky.social · 07/07/2026
This is now published in PNAS! And double-treat, we also made the cover :) www.pnas.org/doi/10.1073/...
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Krishna Shrinivas @shrinivaslab.bsky.social · 08/06/2026
Intrinsically disordered proteins (IDPs) flit between diverse shapes and interact in fuzzy ensembles whose collective properties shape function. Q: Can we rationally design emergent properties of IDPs? Our newest preprint takes a stab at this 🧵 biorxiv.org/content/10.6...
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Biomedical Picture of the Day BPoD @bpodaily.bsky.social · 08/06/2026
Ear Bending: Atlas of genes active in single cells of the developing inner ear 📷 @akankshi.bsky.social & @kkukreja.bsky.social et al @swinburnelab.bsky.social @harvardmed.bsky.social in @elife.bsky.social ➡️ bpod.org.uk/archive/2026...
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Yaniv Elkouby @yanivelkouby.bsky.social · 22/12/2025
🥁We are recruiting PhD students/Postdocs with strong proven background in developmental/molecular/cell biology & related areas, for various projects- check out our lab website👇🏼 We offer: competitive stipends, super equipped lab, fun international team! yanivelkoubylab.com
yanivelkoubylab.com
The Elkouby Lab - Cell and developmental biology of early oogenesis
The Elkouby Lab Illuminating unpredicted cellular machineries in gonad development, germ cell production, and reproduction A Journey to Before the Beginning of Life Exploring the Unknown Developing eg...
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Kalki Kukreja @kkukreja.bsky.social · 21/11/2025
just finished reading katalin kariko @kkariko.bsky.social 's memoir. easily one of the most inspiring books I have read. whenever I feel down at work, face rejections or things feel unfair and hard, I can just hug the book to sleep and remind myself why we do science . . . .
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Krishna Shrinivas @shrinivaslab.bsky.social · 10/10/2025
Happy to share our latest in @natcomputsci.nature.com led by (amazing) Ryan Krueger + colab w M. Brenner! We introduce a framework to directly design intrinsically disordered proteins (IDPs) from physics-based simulations. 🧬 doi.org/10.1038/s435... 📰 www.mccormick.northwestern.edu/news/article...
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Development @dev-journal.bsky.social · 10/10/2025
Coupling and decoupling of the cell cycle from cell differentiation in development In this Spotlight, @kkukreja.bsky.social & Allon Klein discuss the dependence of animal cell differentiation on cell cycle, and how their decoupling facilitates development journals.biologists.com/dev/article-...
Figure 1 - Common chemical and genetic methods for arresting the cell cycle in developmental studies. Function of the mentioned genes/proteins: CDK4/6, cyclin-dependent kinases that phosphorylate Rb, releasing E2F transcription factors to activate S-phase genes and promote the G1→S transition; CDKN1C (p57Kip2), Cyclin-dependent kinase inhibitor; E2f, transcription factor family activating S-phase genes; Rbf, retinoblastoma-family protein that represses E2F activity; Myc, transcription factor promoting cell growth and G1→S progression; APC/C, E3 ubiquitin ligase targeting mitotic regulators for degradation; emi1 (fbxo5), APC/C inhibitor that prevents premature degradation of mitotic regulators; Cdc25, phosphatase that activates Cdk1; Cdk1 (encoded by Cdc2 in Drosophila and Schizosaccharomyces pombe), master cell-cycle kinase driving G2→M transition by phosphorylating substrates for mitotic entry, including condensins, spindle assembly factors and nuclear envelope breakdown proteins.
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Kalki Kukreja @kkukreja.bsky.social · 09/10/2025
Our review on cell cycle – cell fate (de)coupling is out! doi.org/10.1242/dev.... Was a lot of fun writing this with Allon Klein, reading old papers(earliest from 1902), and speculating on why cell cycle progression is not necessary for differentiation across many many tissues and species. (1/3)
doi.org
Coupling and decoupling of the cell cycle from cell differentiation in development
Summary: This Spotlight surveys investigations of the dependence of cellular differentiation on the cell cycle in animals. Strict dependence is uncommon. The decoupling of the cell cycle and different...
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Nature Computational Science @natcomputsci.nature.com · 07/10/2025
📢 @shrinivaslab.bsky.social and colleagues introduce a method for designing unstructured proteins with tunable properties. www.nature.com/articles/s43... 🖥️ 🧬 🔓 rdcu.be/eJSuV
nature.com
Generalized design of sequence–ensemble–function relationships for intrinsically disordered proteins - Nature Computational Science
The authors introduce a method that combines physics and machine learning to design dynamic unstructured proteins with tunable ensemble properties like size, shape, sensing and binding.
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Krishna Shrinivas @shrinivaslab.bsky.social · 22/09/2025
Preprint! Inspired by condensates that form on specific DNA, we ask: can we design multicomponent fluids to form distinct condensates on diff. surfaces? i.e. perform classification by condensation ⚛️ 💻 exploiting phase transitions beyond compartmentalization! arxiv.org/abs/2509.08100 (1/2)
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Krishna Shrinivas @shrinivaslab.bsky.social · 04/09/2025
New in @pnas.org with @gladfelterlab.bsky.social @sneadlab.bsky.social ! 📢 Cells use condensates (dynamic compartments without membranes) to organize key reactions. Some condensates have core & shell layers… but how do such layers form? 🤔 👉 pnas.org/doi/10.1073/pnas.2504778122 (1/6)
pnas.org
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
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Yogesh Goyal @goyallab.bsky.social · 06/07/2025
Excited to share our latest by my postdoc Ben KS: we use statistical physics & Bayesian inference to model genome-wide perturbation outcomes. Remarkably, perturbation responses are encoded in gene "chatter" even before the perturbation–a fundamental insight with broad implications shorturl.at/2LHbw
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Yogesh Goyal @goyallab.bsky.social · 07/07/2025
Excited to share our paper on deciphering the design & control principles of tissue scaling w/ Luisa Arispe! Amazing work by co-first authors Danielle Pi and Jonas Braun. We show *differentiated* endothelial cell proliferate in waves with ultrafast cell cycle time of ~5h www.cell.com/cell-systems...
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Kalki Kukreja @kkukreja.bsky.social · 19/12/2024
Loved this! Using devbio to engineer embryo models with notochord – neat and cool study. Lot of careful characterization of the embryo model.
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Kalki Kukreja @kkukreja.bsky.social · 12/12/2024
My first post on bluesky!! Excited to see my PhD work featured on the cover of NCB @naturecellbiology.bsky.social December issue! This image shows a gorgeous #zebrafish embryo undergoing cell division (the green cells with condensed chromatin)—a fundamental process we study in development. 🧵1/2
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Kalki Kukreja @kkukreja.bsky.social · 04/12/2024
Really liked reading this interview with @karalmckinley.bsky.social , so frank and honest! My favorite part "I think it's easy to get caught up in saying what we think is ‘the right thing’ to succeed, so much so that we can lose sight of what we are truly passionate about".
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Yaniv Elkouby @yanivelkouby.bsky.social · 30/11/2024
🔊 We are recruiting PhD students and Postdocs! We are seeking highly motivated, talented, and creative researchers, with strong background in cell and developmental biology, who are looking to spearhead original interdisciplinary investigations, addressing overlooked biology. 1/5
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Zebrafish Rock! @zebrafishrock.bsky.social · 23/11/2024
New work from @kkukreja.bsky.social & Klein Lab
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Stylianos Lefkopoulos (he/him) @slefkopoulos.bsky.social · 21/11/2024
🥂Congratulations to Klein & co for their new study in our journal (@naturecellbiology.bsky.social) showing that blocking cell division does not affect major cell type differentiation during development, but it does decelerate differentiation of particular cell types. rdcu.be/d0Ry3
rdcu.be
Cell state transitions are decoupled from cell division during early embryo development
Nature Cell Biology - Kukreja et al. show that blocking cell division in zebrafish does not affect differentiation of major cell types during gastrulation and segmentation, but it does decelerate...
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