iiinova — where your digital self keeps evolving

Reposted by Kevin John

Waggoner Lab @labwaggoner.bsky.social · 11/03/2026

Imprinting by influenza virus infection in children can cause a deleterious shift of nearly the entire memory recall response against key, conserved epitopes @nature.com @weillcornell.bsky.social www.nature.com/articles/s41...

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Kevin John @kev-in-science.bsky.social · 06/01/2026

Our follow-up study on IgG4 in blood and saliva after 4 x COVID-19 mRNA vaccines is out on eBioMedicine 🧪 1)🧵So how does IgG4 influence responses to Omicron (XBB.1.5 and JN.1) and Sarbecoviruses (from bats, pangolins)? What epitopes are being targeted? authors.elsevier.com/sd/article/S...

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Reposted by Kevin John

Ruth Amy Purcell @ruthamypurcell.bsky.social · 15/10/2025

Our paper exploring the effects of solid tumor malignancy-associated inflammation upon COVID-19 vaccine-induced antibodies is finally live! We show that while dysregulated inflammation impairs neutralization, variant cross-reactive Fc effector functions remain robust. www.nature.com/articles/s41...

nature.com

Dysregulated inflammation in solid tumor malignancy patients shapes polyfunctional antibody responses to COVID-19 vaccination - npj Vaccines

npj Vaccines - Dysregulated inflammation in solid tumor malignancy patients shapes polyfunctional antibody responses to COVID-19 vaccination

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Reposted by Kevin John

Arc Institute @arcinstitute.org · 24/09/2025

In another preprint from the @brianhie.bsky.social Lab and @synbiogaolab.bsky.social, they introduce Germinal, a generative AI system for de novo antibody design. Germinal produces functional nanobodies in just dozens of tests, making custom antibody design more accessible than ever before.

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Reposted by Kevin John

Bloom lab @jbloomlab.bsky.social · 08/09/2025

In new study led by @ckikawa.bsky.social, we provide near real-time data on human neutralizing antibody landscape to influenza by measuring ~26,000 titers to >100 recent viral strains Data can inform vaccine selection & evolutionary/epidemiological modeling www.biorxiv.org/content/10.1...

biorxiv.org

Near real-time data on the human neutralizing antibody landscape to influenza virus to inform vaccine-strain selection in September 2025

The hemagglutinin of human influenza virus evolves rapidly to erode neutralizing antibody immunity. Twice per year, new vaccine strains are selected with the goal of providing maximum protection again...

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Reposted by Kevin John

Ludivine Grzelak @ludivine-grzelak.bsky.social · 08/09/2025

🎉 Thrilled to share our newest paper and my first one in the Valkenburg lab @thedohertyinst.bsky.social published in @natcomms.nature.com: SARS-CoV-2 antibody responses in children exhibit higher FcR engagement and avidity than in adults doi.org/10.1038/s414... 👇1/5

t.co

https://doi.org/10.1038/s41467-025-63263-y

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Reposted by Kevin John

Journal of Experimental Medicine @jem.org · 03/04/2025

The labs of Krammer, @wchnicholas.bsky.social, Ellebedy et al. identify a neuraminidase-targeting human monoclonal antibody (mAb-297) induced by seasonal #influenza vaccination that broadly protects against multiple influenza A & B strains, incl. avian #H5N1. rupress.org/jem/article/...

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Kevin John @kev-in-science.bsky.social · 01/03/2025

Nice summary and discussion about our recent IgG4 publication that just came out on #scienceadvances from @amywchung.bsky.social lab (kudos to our PhD candidate Carissa Aurelia 👩‍🔬🎉) Glad it has answered some technical questions and raised more for future work/discussion 🧐🔬🧪

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