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Reposted by Amy W Chung

Ruth Amy Purcell @ruthamypurcell.bsky.social · 15/10/2025

Our paper exploring the effects of solid tumor malignancy-associated inflammation upon COVID-19 vaccine-induced antibodies is finally live! We show that while dysregulated inflammation impairs neutralization, variant cross-reactive Fc effector functions remain robust. www.nature.com/articles/s41...

nature.com

Dysregulated inflammation in solid tumor malignancy patients shapes polyfunctional antibody responses to COVID-19 vaccination - npj Vaccines

npj Vaccines - Dysregulated inflammation in solid tumor malignancy patients shapes polyfunctional antibody responses to COVID-19 vaccination

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Reposted by Amy W Chung

Kevin John @kev-in-science.bsky.social · 06/01/2026

Our follow-up study on IgG4 in blood and saliva after 4 x COVID-19 mRNA vaccines is out on eBioMedicine 🧪 1)🧵So how does IgG4 influence responses to Omicron (XBB.1.5 and JN.1) and Sarbecoviruses (from bats, pangolins)? What epitopes are being targeted? authors.elsevier.com/sd/article/S...

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Reposted by Amy W Chung

Ruth Amy Purcell @ruthamypurcell.bsky.social · 12/05/2025

Happy to have the latest @amywchung.bsky.social lab preprint online! 🦠 Here we demonstrated that systemic inflammation in solid tumor malignancy patients was associated with impaired SARS-CoV-2 neutralizing antibody functions while non-neutralizing functions remained robust (yay Fc functions!) 🦠

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Reposted by Amy W Chung

Kevin John @kev-in-science.bsky.social · 01/03/2025

Nice summary and discussion about our recent IgG4 publication that just came out on #scienceadvances from @amywchung.bsky.social lab (kudos to our PhD candidate Carissa Aurelia 👩‍🔬🎉) Glad it has answered some technical questions and raised more for future work/discussion 🧐🔬🧪

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