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Karim Majzoub

@karimaj.bsky.social
2.4K followers 7.3K following 241 posts

Group leader @igmm-montpel.bsky.social studying viruses - Amateur athlete and musician- Husband and father- Europtimist @biolum-montpellier.bsky.social www.igmm.cnrs.fr/en/team/rna-viruse…

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Karim Majzoub @karimaj.bsky.social · 24/09/2026
cell.com
Direct cell-to-cell transmission of retrotransposons
Retrotransposons can infect neighboring cells using a mechanism that relies on a small fusogen-like protein rather than on the envelope protein that is typically required for infection.
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Karim Majzoub @karimaj.bsky.social · 22/09/2026
Switching of transcriptional control from interferon regulatory factor 2 to interferon regulatory factor 1 drives innate immune cell activation
cell.com
Switching of transcriptional control from interferon regulatory factor 2 to interferon regulatory factor 1 drives innate immune cell activation
Toll-like receptor signaling activates proinflammatory interferon-stimulated genes (ISGs) even in the absence of interferon by triggering a shift from IRF2 to IRF1 occupancy at ISG promoters and enhan...
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Karim Majzoub @karimaj.bsky.social · 17/09/2026
@jeremydufloo.bsky.social had a brief and productive visit to our lab one summer ago and he came up with this discovery : Glycosphingolipids are essential entry factors for non-influenza orthomyxoviruses
microbiologyresearch.org
Glycosphingolipids are essential entry factors for non-influenza orthomyxoviruses
Thogotoviruses and quaranjaviruses are arthropod-borne orthomyxoviruses that circulate widely in wildlife and domestic animals and include several zoonotic members. Despite their close phylogenetic re...
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Karim Majzoub @karimaj.bsky.social · 19/08/2026
Pervasive phosphorylation by phage T7 kinase disarms bacterial defences
nature.com
Pervasive phosphorylation by phage T7 kinase disarms bacterial defences - Nature
The T7 bacteriophage deactivates bacterial defence systems through T7K phosphorylation of nearly all host and phage proteins during infection.
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Reposted by Karim Majzoub
Kranzusch Lab @kranzuschlab.bsky.social · 12/08/2026
The shared principles of human and bacterial antiviral immunity An honor to highlight remarkable discoveries from many labs over the past 12 years that unite previously disparate fields of how animal cells and prokaryotes defend against viruses. www.nature.com/articles/s41... rdcu.be/fzwyB
nature.com
Shared principles of human and bacterial antiviral immunity - Nature
The Review describes shared ancient, conserved mechanisms between human antiviral immunity and bacterial anti-phage systems, outlining universal principles of pathogen sensing, signalling and effector...
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Reposted by Karim Majzoub
Sam Díaz-Muñoz (they / ella) @sociovirology.bsky.social · 07/08/2026
@karimaj.bsky.social Now talking about work led by Joe McKellar out this year www.cell.com/cell/fulltex... #SocialViruses26
cell.com
Deltaviruses spread through a viral Trojan Horse
McKellar et al. have discovered that some satellite viruses act as the ultimate hitchhikers. They physically become a virus inside a virus, hiding within helper virus particles by hitching a ride as a...
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Karim Majzoub @karimaj.bsky.social · 01/08/2026
Contagious fish cancer overruns New England lake Catfish melanomas are the first example of a transmissible cancer in fish, genetic studies reveal
science.org
Contagious fish cancer overruns New England lake
Catfish melanomas are the first example of a transmissible cancer in fish, genetic studies reveal
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Karim Majzoub @karimaj.bsky.social · 17/07/2026
RNA structure programs endogenous ADAR for precise and efficient editing
cell.com
RNA structure programs endogenous ADAR for precise and efficient editing
LEAPER 3.0, a structurally optimized dual-bulge ADAR-recruiting RNA design platform, achieves precise and efficient endogenous A-to-I RNA editing across diverse ADAR contexts.
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Reposted by Karim Majzoub
Carolyn Bertozzi @carolynbertozzi.bskyverified.social · 11/07/2026
On the neurological basis of cheating/dishonest behavior affected by social normalization and conformity, very a propos to current political climate
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Karim Majzoub @karimaj.bsky.social · 11/07/2026
Pre-print 🚨 alert from our lab : The RLR-MAVS-IRF3 axis activates the IFN pathway to restrict Tonate virus (TONV) infection
biorxiv.org
The RLR-MAVS-IRF3 axis activates the IFN pathway to restrict Tonate virus (TONV) infection
Tonate virus (TONV) is a neglected mosquito-borne alphavirus of the Venezuelan equine encephalitis complex associated with febrile illness, encephalitis, and fetal central nervous system abnormalities...
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Reposted by Karim Majzoub
Ryan Flynn @raflynn5.bsky.social · 29/06/2026
Taking our first steps towards sequencing the extracellular matrix by “Intact and single-molecule analysis of heparan sulfate” from @phristov.bsky.social in the lab, in collaboration with Miten Jain's lab. "HS-nano-seq" www.biorxiv.org/content/10.6...
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Karim Majzoub @karimaj.bsky.social · 18/06/2026
Very honored and proud to present our work at the French Academy of Science (Académie des sciences) with Joe McKellar who was amongst 6 Laureats this year , getting a prestigious price " Les Grandes Avancées Françaises en Biologie". Bravo @viroscope.bsky.social ! @academiesciences.bsky.social
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Karim Majzoub @karimaj.bsky.social · 11/06/2026
Mitochondria tethered to the nucleus secure its energy supply
nature.com
Mitochondria directly interact with the nuclear pore complex - Nature
Mitochondria interact directly with the nuclear pore complex via VDAC1–RANBP2 binding to sustain nuclear ATP levels.
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Karim Majzoub @karimaj.bsky.social · 01/06/2026
Homing pigeon navigation relies on superparamagnetic macrophages under overcast conditions
science.org
Homing pigeon navigation relies on superparamagnetic macrophages under overcast conditions
Birds use a variety of navigational strategies, including the geomagnetic field, especially when other cues are not available, such as under overcast or nocturnal conditions. Magnetite particles in th...
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Karim Majzoub @karimaj.bsky.social · 28/05/2026
nature.com
Temperate phages enhance bacterial host fitness via RNA-guided flagellar remodelling - Nature Microbiology
The prophage of a clinical Enterobacter isolate uses an RNA-guided transcription factor to alter flagellar composition, leading to enhanced bacterial motility and improved gut colonization in a mouse ...
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Karim Majzoub @karimaj.bsky.social · 25/05/2026
Scavenger receptor class F member 2 is an intracellular receptor for hepatitis B virus
cell.com
Scavenger receptor class F member 2 is an intracellular receptor for hepatitis B virus
Li et al. identified SCARF2 as an intracellular receptor for HBV entry that directs internalized HBV to nuclear pore complexes and facilitates nucleocapsid release from endosomes.
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Reposted by Karim Majzoub
Marcel Dickmanns | 🌿❄️🔬 @madic.bsky.social · 26/07/2025
New preprint: In situ Architecture of #Plasmodesmata. Using #cryoET, #AlphaFold & proteomics, we uncover the native organization of plant intercellular nanopores. 🔗 doi.org/10.1101/2025... 🧪🧵1/n #teamtomo #PlantScience #Physcomitrium #Arabidopsis #cryoEM
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Karim Majzoub @karimaj.bsky.social · 07/05/2026
Broken link for the paper :(
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Karim Majzoub @karimaj.bsky.social · 07/05/2026
nature.com
HIV-1 signalling remodels nuclear pores to licence infection - Nature
HIV-1 capsid nuclear import at the nuclear pore complex is a bottleneck to resting T cell infection, but HIV-1 overcomes this by triggering receptor-mediated signalling during cell–cell spread to driv...
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Reposted by Karim Majzoub
CNRS Biologie @cnrsbiologie.bsky.social · 06/05/2026
Les travaux de @karimaj.bsky.social médaille de bronze du @cnrs.fr, décryptent les stratégies des virus et leurs modes de propagation. À la clé : identifier des cibles thérapeutiques face à des infections encore sans traitement curatif. 🔎 Son portrait : buff.ly/pjtvRHT
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Karim Majzoub @karimaj.bsky.social · 30/04/2026
very nice paper, looking forward to doing it in journal club!
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Elisa Franco @francolab.bsky.social · 29/04/2026
RNA is more than genetic information: it can be a tool for cellular architects. In our new paper, we engineer RNA motifs to physically reorganize intracellular space in living mammalian cells. www.nature.com/articles/s41...
nature.com
Programmable artificial RNA condensates in mammalian cells - Nature Nanotechnology
Modular RNA nanostar motifs spontaneously assemble into programmable synthetic condensates in the nucleus and cytoplasm, with RNA design controlling localization, sequence-specific target recruitment ...
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Reposted by Karim Majzoub
IGMM-Montpellier @igmm-montpel.bsky.social · 28/04/2026
👏 Félicitations à Karim Majzoub @karimaj.bsky.social 🏅Médaille de bronze du CNRS 2026 🧬 Une distinction qui récompense l’excellence de ses travaux de recherche. www.insb.cnrs.fr/fr/personne/... #CNRS #Félicitations #Recherche
insb.cnrs.fr
Karim Majzoub
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Karim Majzoub @karimaj.bsky.social · 27/04/2026
"Beyond hepatitis D virus: the discovery of animal deltaviruses, their diversity, helpers and their position in an expanding world of circular RNA replicons " , enjoy a fresh review coming out from our lab (Zoé Denis, an amazing PhD student as first author) www.sciencedirect.com/science/arti...
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Reposted by Karim Majzoub
IRD @ird-fr.bsky.social · 21/04/2026
🦠🦟 Après avoir goûté aux épidémies de dengue et de chikungunya, l’humanité pourrait bien connaître les rigueurs d’un nouveau pathogène émergent : 𝗹𝗲 𝘃𝗶𝗿𝘂𝘀 𝗧𝗼𝗻𝗮𝘁𝗲. 🔗 Pour en savoir plus 👉 lemag.ird.fr/fr/apres-la-... @cnrs.fr @umontpellier.bsky.social @inrae-france.bsky.social
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Karim Majzoub @karimaj.bsky.social · 20/04/2026
Our paper featured on TWIV with a nice analysis. @51min10secs
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IGMM-Montpellier @igmm-montpel.bsky.social · 17/04/2026
🔬IGMM (CNRS/ Univ Montpellier) is hiring Group Leaders in Innovative Biology. @cnrsbiologie.bsky.social @cnrs.fr @umontpellier.bsky.social 📅 1 May–15 June 2026 📩 search2026@igmm.cnrs.fr 📎Full information 👇 #LifeScience #MolecularBiology #Research #PI #CNRS
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IGMM-Montpellier @igmm-montpel.bsky.social · 15/04/2026
🚀 🚀 Les deltavirus détournent d’autres virus comme “cheval de Troie” pour se propager. 🎧 L’étude de l’équipe de Karim Majzoub (Cell) décryptée dans TWIV🎧 ⏱️ À partir de 51:10 🔗 www.youtube.com/watch?v=qkN9... @karimaj.bsky.social @microbetv.bsky.social
youtube.com
TWiV 1313: Maybe they're all dementia vaccines
YouTube video by MicrobeTV
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Karim Majzoub @karimaj.bsky.social · 28/03/2026
Kudos to @nadinelaguette.bsky.social team and all co-authors on this nice paper where our lab had a modest contribution! @viroscope.bsky.social 🔥
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Reposted by Karim Majzoub
Journal of Experimental Medicine @jem.org · 19/03/2026
Does fever drive the #evolution of antiviral genes? Perspective by Ryan Langlois @langloislab.bsky.social rupress.org/jem/article/... 📘 In our #InnateImmunity collection: rupress.org/jem/collecti... #KSInnateImmune26
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Karim Majzoub @karimaj.bsky.social · 15/03/2026
HIV joining the circular RNAs Club ? Welcome !
nature.com
HIV-1-encoded circular RNA enhances viral transcription through Tat binding - Nature Microbiology
Obi, Yan and colleagues identified an HIV-1-encoded circular RNA (circHIV) in plasma from people living with HIV and in infected primary cells and T-cell lines. CircHIV binds to the viral Tat protein ...
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Reposted by Karim Majzoub
Biomedical Picture of the Day BPoD @bpodaily.bsky.social · 13/03/2026
Hepatitis D virus hitches a ride into host cells inside a helper virus such as hep B acting as a Trojan horse 📹 @viroscope.bsky.social et al @karimaj.bsky.social lab @umontpellier.bsky.social in @cellpress.bsky.social ➡️ bpod.org.uk/archive/2026...
bpod.org.uk
BPoD | Hep D Hitcher
Hep D Hitcher - Biomedical pictures for March 2026.
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Karim Majzoub @karimaj.bsky.social · 09/03/2026
Mabrouk my friend ! Exciting new adventure ! Kisses to Emma
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Karim Majzoub @karimaj.bsky.social · 09/03/2026
Agreed ;)
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Karim Majzoub @karimaj.bsky.social · 09/03/2026
Agreed ;)
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CNRS Biologie @cnrsbiologie.bsky.social · 09/03/2026
#ResultatScientifique🔎| Le stratagème des deltavirus : voyager à bord d’un autre virus 🤝 @karimaj.bsky.social @cnrsoccitanieest.bsky.social @umontpellier.bsky.social @igmm-montpel.bsky.social 📕 buff.ly/Z6ZIvRD
buff.ly
Quand un virus en transporte un autre : le « cheval de Troie » des deltavirus
Certains virus minuscules, appelés deltavirus, ne peuvent se propager qu’en s’appuyant sur d’autres virus.
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Karim Majzoub @karimaj.bsky.social · 08/03/2026
Thanks Priyah ! You already heard the story last year in Spain ;)
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Viroscope @viroscope.bsky.social · 07/03/2026
The Trojan Horse is real, and it’s microscopic! 🐴🦠 Our paper is out today in @cellcellpress.bsky.social! We discovered that deltaviruses physically hide INSIDE helper viruses to sneak into new cells. And to prove it, we had to image them from every angle. 🧵👇 www.sciencedirect.com/science/arti...
sciencedirect.com
Deltaviruses spread through a viral Trojan Horse
Hepatitis D-like satellite viruses, known as deltaviruses, have been recently discovered in a wide range of animals. These viruses are thought to expr…
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Karim Majzoub @karimaj.bsky.social · 07/03/2026
Thanks Sam !
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Karim Majzoub @karimaj.bsky.social · 07/03/2026
Thanks @moritzschussler.bsky.social ! Wish you were with us !
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Karim Majzoub @karimaj.bsky.social · 07/03/2026
Thanks Eric, hope to see you soon ;)
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Karim Majzoub @karimaj.bsky.social · 07/03/2026
Merci Stan, miss you ;)
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Karim Majzoub @karimaj.bsky.social · 07/03/2026
Thanks Mart, we corrected the nomenclature from the BiorXiv version as you suggested. Thanks for your input
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Karim Majzoub @karimaj.bsky.social · 07/03/2026
Thanks Stef !
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Karim Majzoub @karimaj.bsky.social · 06/03/2026
and this is the AI view ;)
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Karim Majzoub @karimaj.bsky.social · 06/03/2026
and this is a Herpes Simplex-Virus 1 with a Deltavirus inside as seen by STED microscopy !
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Karim Majzoub @karimaj.bsky.social · 06/03/2026
This is a snake Arenavirus and a snake deltavirus in it as seen by NS-EM !
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Karim Majzoub @karimaj.bsky.social · 06/03/2026
These were VSV-Deltavirus looked at by Cryo-EM and this one is VSV-deltavirus as seen by Atomic Force Microscopy !
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Karim Majzoub @karimaj.bsky.social · 06/03/2026
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Karim Majzoub @karimaj.bsky.social · 06/03/2026
look at that
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