Karim Majzoub @karimaj.bsky.social · 24/09/2026cell.comDirect cell-to-cell transmission of retrotransposonsRetrotransposons can infect neighboring cells using a mechanism that relies on a small fusogen-like protein rather than on the envelope protein that is typically required for infection. 042
Karim Majzoub @karimaj.bsky.social · 22/09/2026Switching of transcriptional control from interferon regulatory factor 2 to interferon regulatory factor 1 drives innate immune cell activationcell.comSwitching of transcriptional control from interferon regulatory factor 2 to interferon regulatory factor 1 drives innate immune cell activationToll-like receptor signaling activates proinflammatory interferon-stimulated genes (ISGs) even in the absence of interferon by triggering a shift from IRF2 to IRF1 occupancy at ISG promoters and enhan... 020
Karim Majzoub @karimaj.bsky.social · 17/09/2026@jeremydufloo.bsky.social had a brief and productive visit to our lab one summer ago and he came up with this discovery : Glycosphingolipids are essential entry factors for non-influenza orthomyxovirusesmicrobiologyresearch.orgGlycosphingolipids are essential entry factors for non-influenza orthomyxovirusesThogotoviruses and quaranjaviruses are arthropod-borne orthomyxoviruses that circulate widely in wildlife and domestic animals and include several zoonotic members. Despite their close phylogenetic re... 042
Karim Majzoub @karimaj.bsky.social · 19/08/2026Pervasive phosphorylation by phage T7 kinase disarms bacterial defencesnature.comPervasive phosphorylation by phage T7 kinase disarms bacterial defences - NatureThe T7 bacteriophage deactivates bacterial defence systems through T7K phosphorylation of nearly all host and phage proteins during infection. 052
Reposted by Karim MajzoubKranzusch Lab @kranzuschlab.bsky.social · 12/08/2026The shared principles of human and bacterial antiviral immunity An honor to highlight remarkable discoveries from many labs over the past 12 years that unite previously disparate fields of how animal cells and prokaryotes defend against viruses. www.nature.com/articles/s41... rdcu.be/fzwyBnature.comShared principles of human and bacterial antiviral immunity - NatureThe Review describes shared ancient, conserved mechanisms between human antiviral immunity and bacterial anti-phage systems, outlining universal principles of pathogen sensing, signalling and effector... 513161
Reposted by Karim MajzoubSam Díaz-Muñoz (they / ella) @sociovirology.bsky.social · 07/08/2026@karimaj.bsky.social Now talking about work led by Joe McKellar out this year www.cell.com/cell/fulltex... #SocialViruses26cell.comDeltaviruses spread through a viral Trojan HorseMcKellar et al. have discovered that some satellite viruses act as the ultimate hitchhikers. They physically become a virus inside a virus, hiding within helper virus particles by hitching a ride as a... 141
Karim Majzoub @karimaj.bsky.social · 01/08/2026Contagious fish cancer overruns New England lake Catfish melanomas are the first example of a transmissible cancer in fish, genetic studies revealscience.orgContagious fish cancer overruns New England lakeCatfish melanomas are the first example of a transmissible cancer in fish, genetic studies reveal 040
Karim Majzoub @karimaj.bsky.social · 17/07/2026RNA structure programs endogenous ADAR for precise and efficient editingcell.comRNA structure programs endogenous ADAR for precise and efficient editingLEAPER 3.0, a structurally optimized dual-bulge ADAR-recruiting RNA design platform, achieves precise and efficient endogenous A-to-I RNA editing across diverse ADAR contexts. 183
Reposted by Karim MajzoubCarolyn Bertozzi @carolynbertozzi.bskyverified.social · 11/07/2026On the neurological basis of cheating/dishonest behavior affected by social normalization and conformity, very a propos to current political climate 0238
Karim Majzoub @karimaj.bsky.social · 11/07/2026Pre-print 🚨 alert from our lab : The RLR-MAVS-IRF3 axis activates the IFN pathway to restrict Tonate virus (TONV) infectionbiorxiv.orgThe RLR-MAVS-IRF3 axis activates the IFN pathway to restrict Tonate virus (TONV) infectionTonate virus (TONV) is a neglected mosquito-borne alphavirus of the Venezuelan equine encephalitis complex associated with febrile illness, encephalitis, and fetal central nervous system abnormalities... 051
Reposted by Karim MajzoubRyan Flynn @raflynn5.bsky.social · 29/06/2026Taking our first steps towards sequencing the extracellular matrix by “Intact and single-molecule analysis of heparan sulfate” from @phristov.bsky.social in the lab, in collaboration with Miten Jain's lab. "HS-nano-seq" www.biorxiv.org/content/10.6... 12611
Karim Majzoub @karimaj.bsky.social · 18/06/2026Very honored and proud to present our work at the French Academy of Science (Académie des sciences) with Joe McKellar who was amongst 6 Laureats this year , getting a prestigious price " Les Grandes Avancées Françaises en Biologie". Bravo @viroscope.bsky.social ! @academiesciences.bsky.social 050
Karim Majzoub @karimaj.bsky.social · 11/06/2026Mitochondria tethered to the nucleus secure its energy supplynature.comMitochondria directly interact with the nuclear pore complex - NatureMitochondria interact directly with the nuclear pore complex via VDAC1–RANBP2 binding to sustain nuclear ATP levels. 1205
Karim Majzoub @karimaj.bsky.social · 01/06/2026Homing pigeon navigation relies on superparamagnetic macrophages under overcast conditionsscience.orgHoming pigeon navigation relies on superparamagnetic macrophages under overcast conditionsBirds use a variety of navigational strategies, including the geomagnetic field, especially when other cues are not available, such as under overcast or nocturnal conditions. Magnetite particles in th... 130
Karim Majzoub @karimaj.bsky.social · 28/05/2026nature.comTemperate phages enhance bacterial host fitness via RNA-guided flagellar remodelling - Nature MicrobiologyThe prophage of a clinical Enterobacter isolate uses an RNA-guided transcription factor to alter flagellar composition, leading to enhanced bacterial motility and improved gut colonization in a mouse ... 091
Karim Majzoub @karimaj.bsky.social · 25/05/2026Scavenger receptor class F member 2 is an intracellular receptor for hepatitis B viruscell.comScavenger receptor class F member 2 is an intracellular receptor for hepatitis B virusLi et al. identified SCARF2 as an intracellular receptor for HBV entry that directs internalized HBV to nuclear pore complexes and facilitates nucleocapsid release from endosomes. 033
Reposted by Karim MajzoubMarcel Dickmanns | 🌿❄️🔬 @madic.bsky.social · 26/07/2025New preprint: In situ Architecture of #Plasmodesmata. Using #cryoET, #AlphaFold & proteomics, we uncover the native organization of plant intercellular nanopores. 🔗 doi.org/10.1101/2025... 🧪🧵1/n #teamtomo #PlantScience #Physcomitrium #Arabidopsis #cryoEM 1121778
Karim Majzoub @karimaj.bsky.social · 07/05/2026nature.comHIV-1 signalling remodels nuclear pores to licence infection - NatureHIV-1 capsid nuclear import at the nuclear pore complex is a bottleneck to resting T cell infection, but HIV-1 overcomes this by triggering receptor-mediated signalling during cell–cell spread to driv... 042
Reposted by Karim MajzoubCNRS Biologie @cnrsbiologie.bsky.social · 06/05/2026Les travaux de @karimaj.bsky.social médaille de bronze du @cnrs.fr, décryptent les stratégies des virus et leurs modes de propagation. À la clé : identifier des cibles thérapeutiques face à des infections encore sans traitement curatif. 🔎 Son portrait : buff.ly/pjtvRHT 131
Karim Majzoub @karimaj.bsky.social · 30/04/2026very nice paper, looking forward to doing it in journal club! 010
Reposted by Karim MajzoubElisa Franco @francolab.bsky.social · 29/04/2026RNA is more than genetic information: it can be a tool for cellular architects. In our new paper, we engineer RNA motifs to physically reorganize intracellular space in living mammalian cells. www.nature.com/articles/s41...nature.comProgrammable artificial RNA condensates in mammalian cells - Nature NanotechnologyModular RNA nanostar motifs spontaneously assemble into programmable synthetic condensates in the nucleus and cytoplasm, with RNA design controlling localization, sequence-specific target recruitment ... 16319
Reposted by Karim MajzoubIGMM-Montpellier @igmm-montpel.bsky.social · 28/04/2026👏 Félicitations à Karim Majzoub @karimaj.bsky.social 🏅Médaille de bronze du CNRS 2026 🧬 Une distinction qui récompense l’excellence de ses travaux de recherche. www.insb.cnrs.fr/fr/personne/... #CNRS #Félicitations #Rechercheinsb.cnrs.frKarim Majzoub 0102
Karim Majzoub @karimaj.bsky.social · 27/04/2026"Beyond hepatitis D virus: the discovery of animal deltaviruses, their diversity, helpers and their position in an expanding world of circular RNA replicons " , enjoy a fresh review coming out from our lab (Zoé Denis, an amazing PhD student as first author) www.sciencedirect.com/science/arti... 074
Reposted by Karim MajzoubIRD @ird-fr.bsky.social · 21/04/2026🦠🦟 Après avoir goûté aux épidémies de dengue et de chikungunya, l’humanité pourrait bien connaître les rigueurs d’un nouveau pathogène émergent : 𝗹𝗲 𝘃𝗶𝗿𝘂𝘀 𝗧𝗼𝗻𝗮𝘁𝗲. 🔗 Pour en savoir plus 👉 lemag.ird.fr/fr/apres-la-... @cnrs.fr @umontpellier.bsky.social @inrae-france.bsky.social 033
Karim Majzoub @karimaj.bsky.social · 20/04/2026Our paper featured on TWIV with a nice analysis. @51min10secs 0102
Reposted by Karim MajzoubIGMM-Montpellier @igmm-montpel.bsky.social · 17/04/2026🔬IGMM (CNRS/ Univ Montpellier) is hiring Group Leaders in Innovative Biology. @cnrsbiologie.bsky.social @cnrs.fr @umontpellier.bsky.social 📅 1 May–15 June 2026 📩 search2026@igmm.cnrs.fr 📎Full information 👇 #LifeScience #MolecularBiology #Research #PI #CNRS 12428
Reposted by Karim MajzoubIGMM-Montpellier @igmm-montpel.bsky.social · 15/04/2026🚀 🚀 Les deltavirus détournent d’autres virus comme “cheval de Troie” pour se propager. 🎧 L’étude de l’équipe de Karim Majzoub (Cell) décryptée dans TWIV🎧 ⏱️ À partir de 51:10 🔗 www.youtube.com/watch?v=qkN9... @karimaj.bsky.social @microbetv.bsky.socialyoutube.comTWiV 1313: Maybe they're all dementia vaccinesYouTube video by MicrobeTV 082
Karim Majzoub @karimaj.bsky.social · 28/03/2026Kudos to @nadinelaguette.bsky.social team and all co-authors on this nice paper where our lab had a modest contribution! @viroscope.bsky.social 🔥 0105
Reposted by Karim MajzoubJournal of Experimental Medicine @jem.org · 19/03/2026Does fever drive the #evolution of antiviral genes? Perspective by Ryan Langlois @langloislab.bsky.social rupress.org/jem/article/... 📘 In our #InnateImmunity collection: rupress.org/jem/collecti... #KSInnateImmune26 031
Karim Majzoub @karimaj.bsky.social · 15/03/2026HIV joining the circular RNAs Club ? Welcome !nature.comHIV-1-encoded circular RNA enhances viral transcription through Tat binding - Nature MicrobiologyObi, Yan and colleagues identified an HIV-1-encoded circular RNA (circHIV) in plasma from people living with HIV and in infected primary cells and T-cell lines. CircHIV binds to the viral Tat protein ... 0106
Reposted by Karim MajzoubBiomedical Picture of the Day BPoD @bpodaily.bsky.social · 13/03/2026Hepatitis D virus hitches a ride into host cells inside a helper virus such as hep B acting as a Trojan horse 📹 @viroscope.bsky.social et al @karimaj.bsky.social lab @umontpellier.bsky.social in @cellpress.bsky.social ➡️ bpod.org.uk/archive/2026...bpod.org.ukBPoD | Hep D HitcherHep D Hitcher - Biomedical pictures for March 2026. 033
Karim Majzoub @karimaj.bsky.social · 09/03/2026Mabrouk my friend ! Exciting new adventure ! Kisses to Emma 010
Reposted by Karim MajzoubCNRS Biologie @cnrsbiologie.bsky.social · 09/03/2026#ResultatScientifique🔎| Le stratagème des deltavirus : voyager à bord d’un autre virus 🤝 @karimaj.bsky.social @cnrsoccitanieest.bsky.social @umontpellier.bsky.social @igmm-montpel.bsky.social 📕 buff.ly/Z6ZIvRDbuff.lyQuand un virus en transporte un autre : le « cheval de Troie » des deltavirusCertains virus minuscules, appelés deltavirus, ne peuvent se propager qu’en s’appuyant sur d’autres virus. 065
Karim Majzoub @karimaj.bsky.social · 08/03/2026Thanks Priyah ! You already heard the story last year in Spain ;) 000
Reposted by Karim MajzoubViroscope @viroscope.bsky.social · 07/03/2026The Trojan Horse is real, and it’s microscopic! 🐴🦠 Our paper is out today in @cellcellpress.bsky.social! We discovered that deltaviruses physically hide INSIDE helper viruses to sneak into new cells. And to prove it, we had to image them from every angle. 🧵👇 www.sciencedirect.com/science/arti...sciencedirect.comDeltaviruses spread through a viral Trojan HorseHepatitis D-like satellite viruses, known as deltaviruses, have been recently discovered in a wide range of animals. These viruses are thought to expr… 47229
Karim Majzoub @karimaj.bsky.social · 07/03/2026Thanks @moritzschussler.bsky.social ! Wish you were with us ! 110
Karim Majzoub @karimaj.bsky.social · 07/03/2026Thanks Mart, we corrected the nomenclature from the BiorXiv version as you suggested. Thanks for your input 010
Karim Majzoub @karimaj.bsky.social · 06/03/2026and this is a Herpes Simplex-Virus 1 with a Deltavirus inside as seen by STED microscopy ! 110
Karim Majzoub @karimaj.bsky.social · 06/03/2026This is a snake Arenavirus and a snake deltavirus in it as seen by NS-EM ! 120
Karim Majzoub @karimaj.bsky.social · 06/03/2026These were VSV-Deltavirus looked at by Cryo-EM and this one is VSV-deltavirus as seen by Atomic Force Microscopy ! 130