iiinova — where your digital self keeps evolving

Reposted by Thóra Káradóttir Lab

Cambridge Centre for Myelin Repair @centremyelin.bsky.social · 10/05/2026

We are excited to share the news that the @mssocietyuk.bsky.social has renewed our funding for 5 years! We will continue our work, understanding and developing treatments for MS! @cam.ac.uk @camneuro.bsky.social @scicambridge.bsky.social @karadottirlab.bsky.social @pluchinolab.bsky.social

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Reposted by Thóra Káradóttir Lab

Cambridge Centre for Myelin Repair @centremyelin.bsky.social · 11/05/2026

We are hiring a project manager to join our CCMR team!!! Full application details in the thread:

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Thóra Káradóttir Lab @karadottirlab.bsky.social · 23/04/2026

Hvað gerist í heilanum þegar hvíta efnið skaðast? Forvitin/n? Sjáðu hér:go.nature.com/3Qgd47r hi.is/frettir/skem... @haskoliislands.bsky.social

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Thóra Káradóttir Lab @karadottirlab.bsky.social · 23/04/2026

Huge thanks to our collaborators: @gocastelobranco.bsky.social George Malliaras Sabine Dietmann @soyonhonglab.bsky.social🧵 (7/8)

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Thóra Káradóttir Lab @karadottirlab.bsky.social · 23/04/2026

This reframes how we think about neurodegeneration: white matter lesions and grey matter pathology are coupled through a regenerative plasticity program. If we can promote myelin regeneration, we may be able to prevent chronic inflammation that drives MS, Alzheimer's, and related diseases. 🧵 (6/8)

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Thóra Káradóttir Lab @karadottirlab.bsky.social · 23/04/2026

What was surprising was that this grey matter inflammation was not harmful, but essential for myelin regeneration. When we blocked it, remyelination failed. And when remyelination fails, transient inflammation turns chronic — matching the low-grade inflammation seen in neurodegeneration. 🧵 (5/8)

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Thóra Káradóttir Lab @karadottirlab.bsky.social · 23/04/2026

The effects were striking: • 60% drop in neuronal firing • 3× increase in microglial density around neuronal cell bodies • Transient loss of excitatory synapses, engulfed by microglia All ~3.5 mm away from the lesion. 🧵 (4/8)

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Thóra Káradóttir Lab @karadottirlab.bsky.social · 23/04/2026

We used the well-defined olivocerebellar circuit to study the effect of focal white matter lesions on the remote grey matter 🧵 (3/8)

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Thóra Káradóttir Lab @karadottirlab.bsky.social · 23/04/2026

White matter lesions appear early in MS, Alzheimer's, Parkinson's. But their functional impact on neurons has been unclear — and they've been largely dismissed as secondary to neurodegeneration. 🧵 (2/8)

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Thóra Káradóttir Lab @karadottirlab.bsky.social · 23/04/2026

What happens to the brain after focal myelin loss? Our new paper, published today in @nature.com tries to answer this question: go.nature.com/3Qgd47r Details in the 🧵 (1/8)

go.nature.com

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Thóra Káradóttir Lab @karadottirlab.bsky.social · 23/04/2026

Huge thanks to our collaborators: @gocastelobranco.bsky.social George Malliaras Sabine Dietmann @soyonhonglab.bsky.social🧵 (7/8)

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Thóra Káradóttir Lab @karadottirlab.bsky.social · 23/04/2026

This reframes how we think about neurodegeneration: white matter lesions and grey matter pathology are coupled via a regenerative plasticity program. If we can promote myelin regeneration, we may be able to prevent the chronic inflammation that drives MS, Alzheimer's, and related diseases. 🧵 (6/8)

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Thóra Káradóttir Lab @karadottirlab.bsky.social · 23/04/2026

What was really surprising was that this grey matter inflammation was not harmful, but essential for myelin regeneration. When we blocked it, remyelination failed. And when remyelination fails, transient inflammation turns chronic — like the low-grade inflammation seen in neurodegeneration. 🧵 (5/8)

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Thóra Káradóttir Lab @karadottirlab.bsky.social · 23/04/2026

The effects were stricking: • 60% drop in neuronal firing • 3× increase in microglial density around neuronal cell bodies • Transient loss of excitatory synapses, engulfed by microglia All ~3.5 mm away from the lesion. 🧵 (4/8)

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Thóra Káradóttir Lab @karadottirlab.bsky.social · 23/04/2026

We used the well-defined olivocerebellar circuit to study the effect of focal white matter lesions on the remote grey matter 🧵 (3/8)

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Thóra Káradóttir Lab @karadottirlab.bsky.social · 23/04/2026

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