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Kalisvar

@kalisvar.bsky.social
70 followers 30 following 38 posts

Infection Control and Infectious Diseases doc. Interested in all things medicine and travel.

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Reposted by Kalisvar
Angela Huttner @angelahuttner.bsky.social · 21/04/2026
Great #UTI session just starting in Hall A2-1. D Neofytos talking now, Barbara Trautner @bwtrautner.bsky.social up next. #ESCMIDGlobal2026 #IDSky #UTISky
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Martin Kiernan @emrsa15.bsky.social · 20/04/2026
@1healthau.bsky.social presenting the results of the HAPPEN study showing significant reduction in pneumonia through oral hygiene at #ESCMIDGlobal2026. Study already picked up by New Scientist www.newscientist.com/article/2523...
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Eli Perencevich @eliowa.bsky.social · 20/04/2026
In #ESCMIDGlobal2026 session Surgical Site Infection in Solid Organ Transplant session, Nicolas Mueller presented his teams @jamanetworkopen.com cohort study. SSIs were independently associated with graft loss and/or death (hazard ratio [HR], 3.24; P < .01) jamanetwork.com/journals/jam...
jamanetwork.com
Surgical Site Infections, Risk Factors, and Outcomes After Liver Transplant
This cohort study examines the frequency and outcomes associated with surgical site infections in patients who have undergone liver transplant.
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Kalisvar @kalisvar.bsky.social · 19/04/2026
SUMMARY:
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Kalisvar @kalisvar.bsky.social · 19/04/2026
Kitagawa et al. 2021: In a pilot study, an automated 222-nm UVC system in shared bathrooms significantly reduced bacterial contamination on high-touch toilet surfaces (seat, control panel, paper holder), though effects were less on shaded areas, supporting UVC as an adjunct IPC measure.
sciencedirect.com
Pilot study on the decontamination efficacy of an installed 222-nm ultraviolet disinfection device (Care222™), with a motion sensor, in a shared bathroom
Toilet surfaces are contaminated with pathogens, and they may be a vector for disease transmission. In this study, we investigated the efficacy of an …
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Kalisvar @kalisvar.bsky.social · 19/04/2026
Jolivet et al. 2021: a prolonged OXA-48 CPE outbreak showed clonal spread from contaminated toilets to patients, with room exposure to positive toilets strongly associated with acquisition; control required intensive cleaning plus full toilet replacement (e.g. rimless systems).
eurosurveillance.org
Eurosurveillance | Outbreak of OXA-48-producing Enterobacterales in a haematological ward associated with an uncommon environmental reservoir, France, 2016 to 2019
The hospital water environment, including the wastewater drainage system, is increasingly reported as a potential reservoir for carbapenemase-producing Enterobacterales (CPE). We investigated a persistent outbreak of OXA-48 CPE (primarily Citrobacter freundii) in a haematological ward of a French teaching hospital by epidemiological, microbiological and environmental methods. Between January 2016 and June 2019, we detected 37 new OXA-48 CPE-colonised and/or ‑infected patients in the haematological ward. In October 2017, a unit dedicated to CPE-colonised and/or ‑infected patients was created. Eleven additional sporadic acquisitions were identified after this date without any obvious epidemiological link between patients, except in one case. Environmental investigations of the haematological ward (June–August 2018) identified seven of 74 toilets and one of 39 drains positive for OXA-48 CPE (seven C. freundii, one Enterobacter sakazakii, one Escherichia coli). Whole genome comparisons identified a clonal dissemination of OXA-48-producing C. freundii from the hospital environment to patients. In addition to strict routine infection control measures, an intensive cleaning programme was performed (descaling and bleaching) and all toilet bowls and tanks were changed. These additional measures helped to contain the outbreak. This study highlights that toilets can be a possible source of transmission of OXA-48 CPE.
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Kalisvar @kalisvar.bsky.social · 19/04/2026
Kerschner et al. 2025: NDM-5 E. coli persisted despite repeated cleaning and disinfection, causing a multi-year outbreak with patient infections and deaths; control required mechanical interventions (pipe disassembly, high-pressure cleaning, component replacement) plus IPC measures.
link.springer.com
Successful termination of a multi-year wastewater-associated outbreak of NDM-5-carrying E. coli in a hemato-oncological center - Antimicrobial Resistance & Infection Control
Background In May 2018, an outbreak of NDM-5-carrying Escherichia coli (NDM-5-EC) was detected at the hemato-oncology department of a tertiary care center in Austria. This report details the outbreak ...
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Kalisvar @kalisvar.bsky.social · 19/04/2026
Kossow et al. 2017 @cidjournal.bsky.social: redesigning sanitary systems, including rimless toilets, covered drains, and disinfecting water systems, reduced MDR P. aeruginosa in toilets and patient cases with mortality dropping to 0%, highlighting the impact of structural interventions.
academic.oup.com
Control of Multidrug-Resistant Pseudomonas aeruginosa in Allogeneic Hematopoietic Stem Cell Transplant Recipients by a Novel Bundle Including Remodeling of Sanitary and Water Supply Systems
Summary. Through major reconstruction of the water and sanitary system, we were able to significantly reduce the burden of Pseudomonas aeruginosa infection
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Kalisvar @kalisvar.bsky.social · 19/04/2026
Mathers et al. 2018 @cidjournal.bsky.social : although not a direct toilet study, installing hopper covers significantly reduced patient acquisition of KPC organisms, supporting the role of covering high-energy flush systems to limit environmental dispersion from wastewater sources.
academic.oup.com
Intensive Care Unit Wastewater Interventions to Prevent Transmission of Multispecies Klebsiella pneumoniae Carbapenemase–Producing Organisms
The role of the wastewater environment in nosocomial transmission of carbapenemase-producing organisms is increasingly recognized. We demonstrated that env
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Kalisvar @kalisvar.bsky.social · 19/04/2026
Zhang et al. 2025: 92% of droplets are <1 μm, and even with the lid closed, bioaerosols escape via seat gaps; escape rises sharply with gap size (up to ~24–57% at 6 mm, higher for viruses), lid closure reduces but does not eliminate transmission risk.
sciencedirect.com
Study on the air gap effect when closing toilet lid on droplet and pathogen escaping from flushing
Closing the toilet lid before flushing is widely recommended to minimize the dispersal of pathogen-laden aerosols. However, an often-overlooked issue …
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Kalisvar @kalisvar.bsky.social · 19/04/2026
Closing the toilet lid reduces aerosol generation and environmental contamination, particularly for larger particles. Fine aerosols can still escape through lid-seat gaps (up to ~24% leakage), meaning the lid provides partial protection but is not a complete IPC solution.
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Kalisvar @kalisvar.bsky.social · 19/04/2026
Rath et al. 2024 @thejhi.bsky.social: MDR Pseudomonas aeruginosa persisted in all toilets over years (79 events; biofilm reservoir), but toilet to patient transmission was rare under a strict IPC bundle (incl. bromination + H₂O₂); control reduces risk, not contamination
journalofhospitalinfection.com
Whole-genome sequencing reveals two prolonged simultaneous outbreaks involving Pseudomonas aeruginosa high-risk strains ST111 and ST235 with resistance to quaternary ammonium compounds
Water-bearing systems are known as frequent Pseudomonas aeruginosa (PA) outbreak sources. However, many older buildings continue to have sanitary facilities in high-risk departments such as the ICU. W...
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Kalisvar @kalisvar.bsky.social · 19/04/2026
Heireman et al. 2020 @thejhi.bsky.social: outbreak OXA-48 K. pneumoniae found in toilet and drain water with genomic evidence of room-to-room spread via shared plumbing; bleach outperformed acetic acid but neither eradicated contamination.
sciencedirect.com
Toilet drain water as a potential source of hospital room-to-room transmission of carbapenemase-producing Klebsiella pneumoniae
Carbapenemase-producing Enterobacterales (CPE) have rapidly emerged in Europe, being responsible for nosocomial outbreaks.Following an outbreak in the…
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Kalisvar @kalisvar.bsky.social · 19/04/2026
Chemical disinfection is an adjunct outbreak control measure, but effects are often transient. Limitations include biofilm persistence, rapid re-seeding from plumbing, and variable compliance; reduced susceptibility to may further constrain effectiveness.
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Kalisvar @kalisvar.bsky.social · 19/04/2026
Multidrug-Resistant Organisms and Resistance Genes Contaminating Shared Restroom
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Kalisvar @kalisvar.bsky.social · 19/04/2026
Schreck et al. 2021: flushing generates large numbers of aerosols (0.3–3 μm) that can reach ≥1.52 m (breathing height) within seconds. Lid reduces larger droplets but does not prevent escape of fine aerosols, and repeated flushes lead to progressive accumulation in the room despite ventilation
pubs.aip.org
Aerosol generation in public restrooms
Aerosolized droplets play a central role in the transmission of various infectious diseases, including Legionnaire's disease, gastroenteritis-causing norovirus,
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Kalisvar @kalisvar.bsky.social · 19/04/2026
Li et al. 2022: Commercial aircraft. Lid open, a single flush generates ~8,500 aerosols, ~92% submicron, with measurable spikes not just in the bowl but also near the floor and in the breathing zone
sciencedirect.com
Measuring the flushing-generated flow and aerosols in lavatory of commercial aircraft
Lavatory use on commercial aircraft may present a risk of contagion, especially on long-haul flights. Flushing the toilet can induce a strong sweeping…
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Kalisvar @kalisvar.bsky.social · 19/04/2026
Crimaldi et al. 2022: flushing generates a high-energy turbulent jet that rapidly propels aerosols upwards, reaching ~1.5 m (breathing zone) within ~8 seconds; particle counts increase markedly post-flush (especially <1 µm), highlighting rapid exposure potential rather than slow diffusion
nature.com
Commercial toilets emit energetic and rapidly spreading aerosol plumes - Scientific Reports
Scientific Reports - Commercial toilets emit energetic and rapidly spreading aerosol plumes
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Kalisvar @kalisvar.bsky.social · 19/04/2026
Barker & Jones 2005: flushing generates substantial bioaerosols, peaking immediately and remaining detectable for up to 60 minutes; importantly, aerosols arise from both bowl water and contaminated sidewalls, with subsequent fallout leading to contamination of surrounding surfaces.
academic.oup.com
The potential spread of infection caused by aerosol contamination of surfaces after flushing a domestic toilet
Abstract. Aims: To determine the level of aerosol formation and fallout within a toilet cubicle after flushing a toilet contaminated with indicator organis
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Kalisvar @kalisvar.bsky.social · 19/04/2026
The plume is dominated by small particles and reaches the 1.5 m breathing zone within ~8 seconds. So forget about flushing and running. Aerosols can persist in the environment for up to 60 minutes.
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Kalisvar @kalisvar.bsky.social · 19/04/2026
Antimicrobial Resistance & Infection Control(Knowlton et al. 2018): flushing significantly increases bioaerosols (especially with fecal waste), dominated by <3 μm particles, but no reduction across distance or time, indicating a persistent, well-mixed plume rather than localized exposure.
link.springer.com
Bioaerosol concentrations generated from toilet flushing in a hospital-based patient care setting - Antimicrobial Resistance & Infection Control
Background In the United States, 1.7 million immunocompromised patients contract a healthcare-associated infection, annually. These infections increase morbidity, mortality and costs of care. A relati...
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Kalisvar @kalisvar.bsky.social · 19/04/2026
Wilson et al. 2020 @ichejournal.bsky.social : flushing doubles culture positivity (13% → 26%), with pathogens (e.g. Enterococcus spp.) detected up to 1 m; concentrations increase post-flush at all distances, and larger particles (5–10 μm) rise significantly, supporting airborne spread potential.
cambridge.org
Bioaerosols generated from toilet flushing in rooms of patients with Clostridioides difficile infection | Infection Control &amp; Hospital Epidemiology | Cambridge Core
Bioaerosols generated from toilet flushing in rooms of patients with Clostridioides difficile infection - Volume 41 Issue 5
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Kalisvar @kalisvar.bsky.social · 19/04/2026
Understanding horizontal spread, vertical spread, and plume persistence is critical for effective IPC measures. Horizontal spread: Toilet flushing generates bioaerosols spreading ≥1 m with no drop-off (p≈0.91). Mostly <3 μm (respirable) and fecal-origin (e.g. C. difficile, Enterococcus).
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Kalisvar @kalisvar.bsky.social · 19/04/2026
Here’s a thread on the talk I gave at #ESCMIDGlobal 2026: “Toilets: Flushing and Spread of Pathogens” — nicknamed “You can’t outrun the plume.” Using published studies, I covered the key components shown below. There’s a surprising amount of data, but still a lack of high-quality intervention trials
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WHO @who.int · 04/06/2025
New guideline on the clinical management and infection prevention and control of #mpox. This guidance is designed to support: ✅ Patients with mpox — whether at home, in the community, or in healthcare facilities ✅ The health workers and caregivers supporting them 🔗 bit.ly/43YOzjf
Picture of Tresor, a health worker, checks on two-year-old Ibrahim, who is being treated for mpox, at the Nyiragongo General Referral Hospital, north of Goma in the Democratic Republic of the Congo (DRC) on 14 August 2024.
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Alex Sundermann, DrPH @sundermannaj.bsky.social · 28/05/2025
New CID study out from Art Baker & team: 12,855 NTM episodes across 10 hospitals over 8 years 💥 1 in 4 were hospital-onset! 📉 HO rates ⏬ 38% over time but varied 15x btwn hospitals ▶️ They used a clean, simple definition for HO NTM (day 3+) NTM = underestimated #IDSky 🔗 doi.org/10.1093/cid/...
doi.org
Epidemiology of Healthcare Facility-Associated Nontuberculous Mycobacteria From 2012 Through 2020 in a 10-Hospital Network in the United States
Incidence rates of hospital-onset nontuberculous mycobacteria (NTM) episodes decreased from 2014 through 2020 within a hospital network, but rates varied s
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Sean Ong @seanong.bsky.social · 20/05/2025
Honoured to be invited to write this commentary with @steventong.bsky.social, on an excellent target trial emulation study which showed that antibiotic use was not associated with improved outcomes in non-severe COVID-19. jamanetwork.com/journals/jam... #IDSky
jamanetwork.com
Target Trial Emulation for Antibiotic Use in Acute COVID-19
This study by Pulia and colleagues1 reports results from a large population-based cohort using target trial emulation to examine the associations of antibiotic treatment with clinical outcomes in pati...
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Kalisvar @kalisvar.bsky.social · 18/05/2025
9/ 💡Key takeaway: Patient safety demands a zone-based, proactive, multidisciplinary approach to managing both water and wastewater in hospitals. Redefining “water safety” may be one of the most important moves in the AMR era. 🧵/end
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Kalisvar @kalisvar.bsky.social · 18/05/2025
8/ 📊 Whether it’s clinical handwash stations, shower design, or cleaning workflows, each part of the system needs integrated thinking. “Clinically integrated water/wastewater safety” is the new north star—tying engineering, IPC & clinical workflows together.
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Kalisvar @kalisvar.bsky.social · 18/05/2025
7/ 📉 The authors warn against a reactive mindset. Retrofitting drains after AMR outbreaks is costly—and sometimes impossible. New builds must proactively bake in safety. Hospitals designed today will serve during peak AMR eras. We can’t afford to get it wrong.
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Kalisvar @kalisvar.bsky.social · 18/05/2025
6/ 🛠️ The paper suggests renaming Water Safety Groups to Water/Wastewater Safety Groups (you get the idea) —broadening scope to include wastewater hazards, which are often invisible but just as risky.
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Kalisvar @kalisvar.bsky.social · 18/05/2025
5/ 🚿 Some hospitals have responded with “water-free” or “water-lite” ICUs—removing sinks, switching to wipes, etc. These aren’t fringe moves—they’re targeted interventions to stop recurring outbreaks when other measures fail. (Personal note: Implementation not so easy!)
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Kalisvar @kalisvar.bsky.social · 18/05/2025
4/ 🔄 Zone B—the periphery—is often neglected, yet staff interact with it constantly. One ICU study showed only 4% of sink use was for handwashing 🤯 Design flaws here can spread AMR via showers, pantries, even jug-filling.
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Kalisvar @kalisvar.bsky.social · 18/05/2025
3/ 🧠 The term “water safety” masks critical risk zones. The authors redefine hospital plumbing into 3 zones: A) Main water system B) Periphery (e.g. sinks, traps, final 2m of pipe) C) Main wastewater system Each zone needs separate oversight & expertise. #BuiltEnvironment
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Kalisvar @kalisvar.bsky.social · 18/05/2025
2/ The authors argue that our traditional idea of “water safety” is outdated—especially in the age of antimicrobial resistance. They propose a new, more precise framework that accounts for risks from both water and wastewater systems. 🚽🧫 The following are the key points (that I liked) 🧵👇
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Kalisvar @kalisvar.bsky.social · 18/05/2025
🧵1/ We need more research and reviews around “water safety” in healthcare facilities. This new paper in @thejhi.bsky.social by Weinbren et al. (2025) provides a fresh perspective—challenging the idea that it's just about legionella and outlet water quality. 🏥💧 #HospEpi #AMR
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Alex Sundermann, DrPH @sundermannaj.bsky.social · 12/05/2025
🧼 Not all endoscope brushes are created equal A new study in @thejhi.bsky.social compared different brush types ▶️ metal shafts + DuPont fibre bristles removed organic matter >>> than plastic or microfiber brushes More passes = cleaner scopes 📄: www.journalofhospitalinfection.com/article/S019...
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Eli Perencevich @eliowa.bsky.social · 04/05/2025
The 2016 Severe Floods and Incidence of Hemorrhagic Fever With Renal Syndrome in the Yangtze River Basin jamanetwork.com/journals/jam... #openaccess #idsky
jamanetwork.com
Hemorrhagic Fever With Renal Syndrome After Flooding in the Yangtze River Basin
This cross-sectional study examines the association between severe floods and long-term incidence of hemorrhagic fever with renal syndrome in the Yangtze River basin and explores the modifying role of...
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Eli Perencevich @eliowa.bsky.social · 24/04/2025
New: Dwell Time and Risk of Bloodstream Infection With Peripheral Intravenous Catheters #idsky #openaccess jamanetwork.com/journals/jam...
jamanetwork.com
Dwell Time and Risk of Bloodstream Infection With Peripheral Intravenous Catheters
This cohort study analyzes the association of dwell time with the risk of bloodstream infections during peripheral intravenous catheter maintenance therapy.
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Kalisvar @kalisvar.bsky.social · 16/04/2025
8/ Bottom line? This Singapore study offers a real-world, real-cost case for smart PPE deescalation. 🛡️ Safety preserved 💵 Costs down 🌱 Carbon cut It’s time to reimagine IPC and assess how we protect health workers — and the planet.
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Kalisvar @kalisvar.bsky.social · 16/04/2025
6/ The accompanying editorial calls this a “larger imperative.” jamanetwork.com/journals/jam... We’re not just talking COVID-19 here — it’s a pivot toward sustainable, evidence-aligned PPE use across all of healthcare. The gowns we use (and toss) daily? They have a carbon footprint too.
jamanetwork.com
Optimizing Personal Protective Equipment for a Sustainable Future
The important study by Sutjipto et al1 shows that deescalating personal protective equipment (PPE) requirements for COVID-19 can reduce cost and carbon impacts without compromising safety. This 24-mon...
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Kalisvar @kalisvar.bsky.social · 16/04/2025
5/But it wasn’t just about safety. Check out the sustainability win: 💥 440,532 disposable gowns saved ♻️ 66,080 kg plastic waste avoided 🌍 398,681 kg CO₂ emissions prevented 💸 ~SGD 454k (USD ~$334k) saved
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Kalisvar @kalisvar.bsky.social · 16/04/2025
4/💡Result: No increase in infections. COVID-19 incidence among staff tracked with community trends. ➕ Median staff-to-community infection ratio actually dropped from 2.6 to 1.5 after PPE deescalation. Safety? ✔️
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Kalisvar @kalisvar.bsky.social · 16/04/2025
3/📊 The study looked at 12 months before & after the policy change at a major hospital campus. ⚕️ >10,000 healthcare staff 🗓️ 24 months of data Key question: Did COVID-19 cases among staff rise post-change?
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Kalisvar @kalisvar.bsky.social · 16/04/2025
2/📍Context: In Sept 2022, Singapore deescalated PPE guidance for routine COVID-19 care: From → Gowns, gloves, eye protection & N95 To → Just N95s. Controversial? Maybe. But what happened next is worth examining.
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Kalisvar @kalisvar.bsky.social · 16/04/2025
1/ 🧵 New study out of Singapore's National Centre for Infectious Diseases: Can less PPE still keep healthcare workers safe from COVID-19 — while saving the planet? Turns out, yes. Let's unpack! #SkyThread #InfectionControl #PPE #HealthcareSustainability jamanetwork.com/journals/jam...
jamanetwork.com
Plastic Waste and COVID-19 Among Hospital Staff After Deescalation in PPE Use
This quality improvement study evaluates whether personal protective equipment (PPE) deescalation guidelines in Singapore was associated with staff COVID-19 incidence as well as the environmental sust...
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Sean Ong @seanong.bsky.social · 13/04/2025
Looking forward to another packed day at #ESCMIDGlobal. Come say hi at 12:00 at Poster 0737 (Sector A/6/5) where I will be presenting our experience with the vanguard phase of the BALANCE+ Platform, our new platform trial for Gram-negative BSI. Open to new collaborators and sites to join!
Flowchart for the BALANCE+ platform trial, with domains including de-escalation vs no de-escalation, oral beta-lactams vs non-beta-lactams, routine follow-up blood cultures, line retention vs removal, and ceftriaxone vs carbapenems for AmpC.
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Journal of Hospital Infection @thejhi.bsky.social · 12/04/2025
Thanks to @kalisvar.bsky.social for his comprehensive overview of everything new in environmental cleaning, surface transmission dynamics, and mopping up MDROs #AntimicrobialResistance
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ESCMID @escmid.bsky.social · 12/04/2025
The #ESCMIDGlobal 2025 "Year in Infection Control" symposium starts soon in Hall 1! Chairs Nico Tom Mutters and Ermira Tartari, alongside speakers Andrew James Stewardson and @kalisvar.bsky.social , will review the top papers from the past year, ongoing controversies, and take-home messages.
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Eli Perencevich @eliowa.bsky.social · 28/03/2025
VA Research Under Threat (no paywall) #openaccess #medsky jamanetwork.com/journals/jam...
jamanetwork.com
Veterans Affairs Research Under Threat
This Viewpoint discusses the critical importance of continued funding for the intramural research program in the Department of Veterans Affairs.
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