iiinova — where your digital self keeps evolving

Reposted by Jaewon Yoon

Martin Steinegger 🇺🇦 @martinsteinegger.bsky.social · 01/08/2026

Riboseek is a fast RNA/DNA search. More sensitive than nhmmer at 250x speed. Structure-aware realignment produces MSAs approaching rMSA quality. Plus 1.7M precomputed RNA MSAs, and an API to search your own 📄 www.biorxiv.org/content/10.6... 💾 github.com/steineggerla... 🌐 search.foldseek.com/riboseek

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Reposted by Jaewon Yoon

hbkgenomics.bsky.social @hbkgenomics.bsky.social · 06/06/2026

Does your designed active site already exist in nature? Is an uncharacterized protein hiding a catalytic site or a pocket? Folddisco answers both, searching millions of structures for a 3D motif in seconds. @natbiotech.nature.com 🧬 📄 www.nature.com/articles/s41... 🧵1/7👇

nature.com

Structural motif search across the protein universe with Folddisco - Nature Biotechnology

Folddisco enables protein structural motif search in million scale databases.

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Reposted by Jaewon Yoon

Martin Steinegger 🇺🇦 @martinsteinegger.bsky.social · 06/06/2026

Meet the Folddisco Marv, designed by Hyunbin Kim, who also developed Folddisco.

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Reposted by Jaewon Yoon

Martin Steinegger 🇺🇦 @martinsteinegger.bsky.social · 06/06/2026

Folddisco is now published @natbiotech.nature.com. It’s a fast motif search for similar 3D DISCOntinuous residues like catalytic sites or zinc fingers across the entire protein universe. 📄 www.nature.com/articles/s41... 💾 folddisco.foldseek.com 🌐 search.foldseek.com/folddisco

nature.com

Structural motif search across the protein universe with Folddisco - Nature Biotechnology

Folddisco enables protein structural motif search in million scale databases.

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