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Reposted by Jonathan Brenton

Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 26/06/2026

What determines whether neurons resist or succumb to #ParkinsonsDisease? Discovery Fellows Jonathan Brenton, Kate Brynildsen, Raquel Garza Gomez, and Weiqiang Liu are uncovering how gene regulation, RNA processing, and epigenomic programs shape neuronal resilience ⬇️ 🔗 bit.ly/3PzdS7h

Graphic with a purple-to-blue gradient background titled “Neuronal Resilience and Transcriptional Regulatory Programs.” Subheading: “Decoding gene regulatory mechanisms that drive degeneration or resilience to enable precision therapeutic strategies.” Below are four circular headshots of researchers in the CRN Discovery Fellowship with their affiliations: Jonathan Brenton, PhD (Home: Team Hardy; Host: Team Alessi); Julia (Kate) Brynildsen, PhD (Home: Team Biederer; Host: Team Gradinaru); Raquel Garza Gomez, PhD (Home: Team Jakobsson; Host: Team Voet); and Weiqiang Liu, PhD (Home: Team Scherzer; Host: Team Rio).

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Reposted by Jonathan Brenton

Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 21/04/2026

Meet the 2026 ASAP CRN Discovery Fellows 🧪 This fellowship supports early-career scientists as they build independent research programs in #ParkinsonsResearch while developing the next generation of scientific leaders. 🔗 bit.ly/4cxE9vz

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Reposted by Jonathan Brenton

Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 26/01/2026

CRN Team Hardy found that a splice variant of PMCA2 localizes to the lysosome and helps regulate lysosomal calcium. Disruption of this pathway contributes to both Niemann-Pick disease type C and #ParkinsonsDisease 🧪 🔗 Read the full #preprint: bit.ly/4jOyOSl

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Reposted by Jonathan Brenton

Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 29/12/2025

CRN Teams Hardy & Wood's new #preprint identifies a new molecular hallmark of #Parkinsons: widespread mis-splicing linked to loss of nuclear TDP-43 function 🧪 They show a robust signature across idiopathic cases and the LRRK2 p.G2019S mutation, validated in human & mouse models. 🔗 bit.ly/3L6ORxW

The LRRK2 p.G2OI 9S KI mouse model exhibits TDP-43 dependent mis-splicing with concurrent loss of nuclear TDP-43 protein in neurons.

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Reposted by Jonathan Brenton

bioRxiv Neuroscience @biorxiv-neursci.bsky.social · 09/09/2025

TDP-43 loss of function drives aberrant splicing in Parkinson's disease www.biorxiv.org/content/10.1101/202…

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Reposted by Jonathan Brenton

bioRxiv Neuroscience @biorxiv-neursci.bsky.social · 28/08/2025

Microglial activation and alpha-synuclein oligomers drive the early inflammatory phase of Parkinson's disease www.biorxiv.org/content/10.1101/202…

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