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Juraj Ahel

@juraj-ahel.bsky.social
52 followers 96 following 4 posts
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Reposted by Juraj Ahel
ahellab.bsky.social @ahellab.bsky.social · 18/07/2025
The application deadline has been extended for a postdoc position in our lab until August 22. Please enquire/apply if you are interested in ADP-ribosylation, ubiquitination, genome stability or immunity. my.corehr.com/pls/uoxrecru...
my.corehr.com
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Reposted by Juraj Ahel
Kevin Mitchell @wiringthebrain.bsky.social · 16/07/2025
This isn't a coincidence, IMO. The fly community is generally super rigorous - because there are so many tools and techniques available, people expect you to really nail things in order to get published (and keep getting funded)
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Juraj Ahel @juraj-ahel.bsky.social · 06/07/2025
What my brother @aheljo.bsky.social works on nowadays :)
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Reposted by Juraj Ahel
ahellab.bsky.social @ahellab.bsky.social · 24/05/2025
A postdoc position is available in our lab to study ADP-ribosylation and ubiquitylation signalling! We are looking for someone with experience in structural biology and biochemistry. The application deadline is June 20th. my.corehr.com/pls/uoxrecru...
my.corehr.com
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Reposted by Juraj Ahel
Marcin J. Suskiewicz @msuskiewicz.eurosky.social · 23/05/2025
Happy to share a new little paper from our team - by @origichals.bsky.social et al. It describes a strategy to make SUMO1 more crystallisable by fusing it with a helper domain. Check out the nice ITC showing it still binds to SIM motifs. We are now working on co-crystallisation with SIM peptides.
onlinelibrary.wiley.com
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Reposted by Juraj Ahel
ahellab.bsky.social @ahellab.bsky.social · 24/05/2025
A few years back we discovered a novel dual hybrid protein modification composed of ADP-ribose dinucleotide and ubiquitin (ADPr-Ub): pubmed.ncbi.nlm.nih.gov/36197986/
biorxiv.org
| bioRxiv
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
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Juraj Ahel @juraj-ahel.bsky.social · 22/05/2025
Happy that my work on RNF213 has been published as a part of doi.org/10.1038/s414...! Many thanks to all the groups involved: @clausenlab.bsky.social @e3chembio.bsky.social @fletcherlab.bsky.social Have a look at the summary from Fletcher lab for an insider perspective of the paper's history:
doi.org
ATP functions as a pathogen-associated molecular pattern to activate the E3 ubiquitin ligase RNF213 - Nature Communications
RNF213 is an E3 ligase with ATPase activity. Here, the authors show that RNF213 is activated by ATP binding and senses cellular energy states, and reveal a transthiolation mechanism induced by immune ...
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