Phosphorylation of hundreds of protein extracellular domains is mediated by two kinase families but the functional role of these kinases is underexplored. We find that the presynaptic release of the t...

Liraglutide, a member of the family of blockbuster weight-loss drugs, reduces headaches by half in a small study.

UC Davis faculty Sergey Stavisky, Theanne Griffith and Elisa Zhang receive prestigious early-career recognition from McKnight Endowment Fund and the Howard Hughes Medical Institute.

Satellite glial cells (SGCs) envelop the somata, axon hillock, and initial axon segment of sensory neurons in the dorsal root ganglia (DRG), playing a critical role in regulating the neuronal microenv...

Nageotte nodules, once overlooked, may hold the key to understanding and treating diabetic peripheral neuropathy.

Fofie et al. present a high-content screening platform using hiPSC-derived nociceptors cultured on multi-well multielectrode arrays to identify peripheral analgesics with diverse mechanisms of action....

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The authors describe a susceptibility of the peripheral nervous system to neuronal senescence with age or injury relevant for sensory dysfunction, such as chronic pain.

The recent approval of suzetrigine for acute pain treatment highlights both the success of targeting peripheral sensory neurons for pain management and the potential of developing new pain therapies p...

Nageotte nodules in the dorsal root ganglia were first described 100 years ago, but little is known about them. Here, the authors link Nageotte nodules to neurodegeneration in diabetic neuropathy in h...

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During pathological conditions, tactile stimuli can aberrantly engage nociceptive pathways leading to the perception of touch as pain, known as mechan…

This randomized clinical trial assesses the effect of metformin on knee pain among patients with symptomatic knee osteoarthritis and overweight or obesity.

The unexpected elimination of funding for the decades-long research project focused on women's health shocked scientists. They were heartened by the quick restoration of support.

In shock move, four institute directors at the US biomedical agency are removed from their posts.

Despite the prevalence of chronic pain, the approval of novel, non-opioid therapeutics has been slow. A major translational challenge in analgesic development is the difference in gene expression and ...

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Zhang et al. identify unimodal neural representations in the spinal cord of cutaneous mechanical and heat stimuli gated by a shared feed-forward local inhibitory neuron type and a neural transition du...

This position will be responsible for managing and overseeing the day-to-day operations of the Human Nociceptor and Spinal Cord Molecular Signature Center under the direction of Dr. Ted Price. Key dut...