Sign in

Jason Climer

@jrclimer.bsky.social
235 followers 295 following 8 posts

Assistant prof at UIUC interested in memory and how neural representations evolve over time. climerlab.org

PostsRepliesMedia
Jason Climer @jrclimer.bsky.social · 23/07/2025
If you’re interested in these questions, I’m recruiting a post-doc to join our team at the University of Illinois Urbana-Champaign! You may find the job posting here: mcb.illinois.edu/climerpostdoc
mcb.illinois.edu
Climer Lab postdoc search.docx | School of Molecular & Cellular Biology | Illinois
021
Jason Climer @jrclimer.bsky.social · 23/07/2025
There’s a lot left to understand here. Why are so few neurons stable? What are the molecular and activity factors that are driving the increased excitability in the stable cells? What is the role of these changes in memory function? Why does drift seem to vary across brain regions and species?
110
Jason Climer @jrclimer.bsky.social · 23/07/2025
So what drives drift? We looked closely at the neurons and found that a small group of them were stable. These stable neurons were more excitable than neighboring cells, making the fate of the cells predictable.
162
Jason Climer @jrclimer.bsky.social · 23/07/2025
We then looked at sensory variability - controlling or varying the smells animals received each day. Again, drift persisted at the same rate - suggesting that subtle sensory variability that is not relevant to the task isn’t the driver of drift either.
110
Jason Climer @jrclimer.bsky.social · 23/07/2025
We first looked at behavior - comparing similar to dissimilar speed profiles - and found that there was no difference in drift between these sets of data. Place cells drifted at the same rate in both sets of behavior, ruling out behavior as the driver of drift.
110
Jason Climer @jrclimer.bsky.social · 23/07/2025
Representational drift is how neurons change information across time. It is controversial because stable memory is thought to be encoded by stable representations. It may be due to behavioral or sensory variability, so we looked at this in place cells using multisensory virtual reality.
100
Jason Climer @jrclimer.bsky.social · 23/07/2025
This was a phenomenal team project, and I deeply respect and admire my co-authors. Daniel Oh will finish his PhD soon and Heydar Davoudi is on the faculty job market this fall.
100
Jason Climer @jrclimer.bsky.social · 23/07/2025
I’m excited to share my final co-first author paper from my postdoc in Dan Dombeck's lab! We explored how behavior, senses, and neurons influence how much information in the brain changes over time. www.nature.com/articles/s41... #science #research #neuroscience #hippocampus #placecells
nature.com
Hippocampal representations drift in stable multisensory environments - Nature
Tracking of individual place cells in mouse CA1 shows that representational drift is not influenced by changes in environment or behaviour, and is lower for more excitable place cells.
28325
Reposted by Jason Climer
Michael Goard @michaelgoard.bsky.social · 25/06/2025
Very happy to see a Transmitter (@thetransmitter.bsky.social) piece on our recent work on estrous cycle modulation of hippocampal structure and function. Thanks to Sydney Wyatt (@sydneywyatt.bsky.social) for covering the work and its context: www.thetransmitter.org/neuroendocri...
thetransmitter.org
Spatial learning circuitry fluctuates in step with estrous cycle in mice
Cyclic shifts in estradiol levels coincide with changes in dendritic spine density and the activity of place cells in the CA1 region of the hippocampus, a new study shows.
03010
Reposted by Jason Climer
Bratislav Misic @misicbata.bsky.social · 20/06/2025
Benchmarking methods for mapping functional connectivity in the brain | doi.org/10.1038/s415... What is the best measure of functional connectivity (FC)? led by @zhenqi.bsky.social in @natmethods.nature.com ⤵️
48744
Reposted by Jason Climer
Steve Maren @stevemaren.bsky.social · 24/05/2025
🚨New paper alert! 🚨 Inactivation of the nucleus reuniens causes relapse of extinguished fear. Here we show this “circuit-induced relapse” depends on hippocampal fear memories and is mediated by hippocampal engrams. Congrats to the team!
urldefense.com
Hippocampal ensembles regulate circuit-induced relapse of extinguished fear
Molecular Psychiatry - Hippocampal ensembles regulate circuit-induced relapse of extinguished fear
27122
Reposted by Jason Climer
allen institute @alleninstitute.org · 25/03/2025
✨ Announcing a new glutamate indicator - iGluSnFR4! ✨ Launched as a pair, iGLuSnFR4s and iGluSnFR4f have high-sensitivity and fast activation/deactivation for recording synapses. More on the indicators and what they are already revealing: www.biorxiv.org/content/10.1... 🧠📈
311526
Reposted by Jason Climer
Tim Behrens @behrenstimb.bsky.social · 25/03/2025
This is great from @neuralreckoning.bsky.social
132
Reposted by Jason Climer
bioRxiv Neuroscience @biorxiv-neursci.bsky.social · 21/03/2025
All-optical electrophysiology reveals behavior-dependent dynamics of excitation and inhibition in the hippocampus www.biorxiv.org/content/10.1101/202…
097
Reposted by Jason Climer
Jon Rueckemann @jonrueckemann.bsky.social · 18/11/2024
This list has doubled. Who haven’t I found?
121