Plesa, Jung and colleagues conduct an in vitro transcriptomic reprogramming screen and identify splicing factor SRSF1 as capable of reducing transcriptomic age without loss of cell identity; they then...

The rebuttal letter is a vitally important document when revising a manuscript for a journal. Here we discuss how to communicate about your manuscript revisions in the best possible light.

Jonathan, a giant tortoise who has lived on the remote South Atlantic island of St. Helena for almost two centuries, could hold the key to a longer life.

The secret to Jonathan the tortoise’s extreme longevity may be in keeping genes tidy

The extraordinary lifespan variation in domestic dogs provides a natural experiment for testing how intrinsic rates of biological aging shape lifespan. Using 1640 methylomes from 894 dogs, we develope...

What is the ultimate goal of biogerontology (the study of the biology of aging)? A fashionable answer these days, often encountered, is that it is to extend healthspan not lifespan. Here we argue that...

Currently, no generalizable tools exist for predicting the impact of interventions on aging using gene expression changes. Here, we build a model for predicting potential geroprotectors by deconstruct...

In this Review, Dimmeler and Augustin discuss microvascular aging as an emerging key driver of tissue dysfunction and systemic decline, highlighting how single-cell and multiomic approaches are uncove...

Ageing reflects progressive decanalization of mammalian cell identity, driven by erosion of a regulatory grammar written during development.

New studies pour cold water on a prominent rejuvenation idea.

Aging is often described as a monotonic accumulation of cellular damage, yet all-cause mortality follows a U-shaped trajectory with age, suggesting non-monotonic molecular changes. We investigated lin...

Cancer Gene Therapy - Clinical translation of senescence-related pan-cancer multi-omics: tools for assessment and immunotherapy prediction

Peto’s paradox establishes how cancer incidence mostly does not scale predictably with body size or lifespan among different species. Here, the authors explore this relationship by examining the evolu...

Organisms vary in their lifespan. Understanding this variation may help us live healthier and longer. Here, we focus on species living twice as long as humans, or more. Out of the 101 multicellular s

In the nervous system, aging causes deterioration of cellular and molecular processes that are associated with declines in cognition, sensory perception, and motor coordination. Aging is also the stro...

Mutations accumulate in cells with age, while caloric restriction extends lifespan across diverse animals. Grońska-Pęski et al. study the effect of caloric restriction on mutations genome-wide in mice...

Understanding the primary molecular and cellular drivers of aging and how they trigger systemic functional decline remains a fundamental challenge. This review focuses on two proposed drivers of agin

Scientists are studying why some species live so much longer than others

At the SENESCENCE2030 Annual Conference and Industry–Academia Workshop held in Coimbra, Portugal, in May 2026, researchers, clinicians, industry representatives and policy stakeholders identified the ...

Comparative and functional analyses of Myotis bats uncover unique patterns of adaptation in virus-interacting proteins and longevity-associated pathways, linking two hallmarks of bat biology.

Ageing has often been conceptualized as a gradual, linear decline, yet growing evidence suggests it unfolds through dynamic, stage-specific transitions. In this Perspective, the authors examine such e...

Biological sciences; Genetics; Cell biology

Aging is influenced by both genetic and environmental factors, yet comparative studies across species with different natural lifespans remain limited. We examined how reduced ambient temperature (18 °...

Retaining Europe's brightest researchers to drive the next generation of life science breakthroughs.

The Greenland shark (Somniosus microcephalus) is a deep-sea vertebrate inhabiting the cold waters of the North Atlantic and Arctic Ocean and is renowned for its exceptional longevity, with individual...

Because of population aging and morbidity expansion, extending healthspan has become a global challenge and it is required to elucidate molecular mechanisms ...

Novo Nordisk's ziltivekimab failed to reduce cardiovascular events in the phase 3 ZEUS trial despite confirmed IL-6 target engagement.

Biological age describes how a person is aging on molecular, cellular, and physiological levels. At the present time, biological age is not something that can b...

Dietary restriction (DR) extends lifespan in many animal species. In C. elegans , Eat mutants with pharyngeal defects that impair feeding exhibit reduced growth rate and fertility and are typically lo...

Aging remains a mystery of biology, and debate regarding why we age has been ongoing for centuries. Many theories of aging have been proposed, most of which focus on errors and the gradual accumulati