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Jonathon L. Baker, Ph.D. @jonbakerlab.bsky.social · 01/09/2026

Oral Microbiology and Immunology 4th Edition is out (ASM Press; ISBN: 978-1-683-67511-2). I wrote Chapter 9: From Bacterial Genetics to Genomics! Many thanks to the Editors for the honor of contributing! #microbiology #dentistry www.wiley.com/en-us/shop/g...

wiley.com

Oral Microbiology and Immunology, 4th Edition

<p><b>The updated reference integrating oral microbiology and immunology for dentistry</b> <p>The study of oral microbiology and immunology has entered a new era, shaped by transformative advances in ...

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Jonathon L. Baker, Ph.D. @jonbakerlab.bsky.social · 23/08/2026

New publication in collaboration with the Pfeifer Lab at OHSU. We identified commercially available drugs capable of inhibiting GtfC, a critical enzyme for biofilm initiation and cohesion by the pathogen, Streptococcus mutans. #microbiology #dentistry www.nature.com/articles/s41...

nature.com

Drug repurposing for glucosyltransferase inhibition for targeted oral biofilm disruption - npj Biofilms and Microbiomes

npj Biofilms and Microbiomes - Drug repurposing for glucosyltransferase inhibition for targeted oral biofilm disruption

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Jonathon L. Baker, Ph.D. @jonbakerlab.bsky.social · 09/08/2026

Without the ability to create MUFAs, the cells of all 3 species were more susceptible to acid stress and antibiotics. Furthermore, S. mutans had its ability to produce toxins impaired and S. mutans and S. pneumoniae were more susceptible to killing by human neutrophils.

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Jonathon L. Baker, Ph.D. @jonbakerlab.bsky.social · 30/04/2026

J. Craig Venter (1946-2026) Polarizing, but an absolute science rock star who drove some of the most significant scientific accomplishments in my lifetime. Forever grateful and proud to have had the privilege of 5 formative years learning #bioinformatics while working for @jcv.bsky.social

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Jonathon L. Baker, Ph.D. @jonbakerlab.bsky.social · 09/04/2026

Importantly, all three methylation systems appear to contribute to pathogenicity, as their loss leads to reduced virulence associated traits.

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Jonathon L. Baker, Ph.D. @jonbakerlab.bsky.social · 09/04/2026

We found methylation in UA159 at: 1️⃣ GATC via DpnII 2️⃣ CGANNNNNNNTCY via HsdM (previously unstudied in S. mutans) 3️⃣ CTGNAG via DnmA—both the gene and motif were discovered in this study Deletion of any of these systems resulted in a complete loss of methylation at the cognate DNA sequence.

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Jonathon L. Baker, Ph.D. @jonbakerlab.bsky.social · 09/04/2026

New preprint! Using cutting edge epigenomics, we comprehensively identified DNA methylation in the model oral pathogen Streptococcus mutans UA159 and uncovered its three distinct sources. #microbiology #dentistry www.biorxiv.org/content/10.6...

biorxiv.org

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Jonathon L. Baker, Ph.D. @jonbakerlab.bsky.social · 27/03/2026

Congratulations to our NIH R25 DORS Intern, Sadie Drucker, who presented her research this week at the International Association for Dental Research conference in San Diego, and is a Finalist for the Cariology Research Group Student Research Award! Way to go Sadie! #microbiology #dentistry

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Jonathon L. Baker, Ph.D. @jonbakerlab.bsky.social · 06/03/2026

Matthew Barbisan and Mingzhe Guo did a great job presenting some of their research in our lab at OHSU School of Dentistry Research Day 2026!

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Jonathon L. Baker, Ph.D. @jonbakerlab.bsky.social · 03/03/2026

At the OHSU School of Dentistry AI in Research Symposium, I presented that AI is a major driver of advances in third-generation sequencing technologies (e.g., Nanopore and PacBio). Our lab is using Nanopore sequencing to study DNA and RNA modifications in oral bacteria. #microbiology #dentistry

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Jonathon L. Baker, Ph.D. @jonbakerlab.bsky.social · 07/01/2026

There were 3 main sources of 6mA: 1) at GATC via DpnII (motif/genes already known; PMID 39624001) 2) at CGANNNNNNNTCY via HsdM (characterized in other species, but not S. mutans, novel recognition motif) 3) at the novel motif CTGNAG via a currently unknown gene Preprint and GitHub repo soon

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Jonathon L. Baker, Ph.D. @jonbakerlab.bsky.social · 07/01/2026

Epigenomics and epitranscriptomics, the next revolution enabled by third-generation sequencing. Our lab used nanopore sequencing to characterize the epigenome of the model pathogen Streptococcus mutans UA159 at single-nucleotide resolution, revealing 3 types of methylation. #microbiology

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Jonathon L. Baker, Ph.D. @jonbakerlab.bsky.social · 03/01/2026

Nice to see this out! Our group found the tools and suggestions provided here super helpful!

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Jonathon L. Baker, Ph.D. @jonbakerlab.bsky.social · 17/12/2025

Very pleased to share that our recent article with @veeninglab.com in @natcomms.nature.com was selected for the Editor's Highlights, which aims to showcase the 50 best papers recently published in the area of #microbiology & infectious diseases! www.nature.com/collections/...

nature.com

Microbiology and infectious diseases

This page highlights recent articles on all aspects of bacteriology, mycology, parasitology and virology, covering the biology of pathogens, host-pathogen ...

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Jonathon L. Baker, Ph.D. @jonbakerlab.bsky.social · 25/11/2025

fasR (spv0647) is a transcriptional regulator, a ∆fasR strain grew poorly at higher temperature (mimicking fever), reduced unsaturated fatty acids, and reduced expression of fabM, fakB3, and bioY-all involved in fatty acid synthesis and/or utilization.

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Jonathon L. Baker, Ph.D. @jonbakerlab.bsky.social · 22/11/2025

This research was also just accepted for publication at the journal mSpectrum!

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Jonathon L. Baker, Ph.D. @jonbakerlab.bsky.social · 22/11/2025

Last week, Molly Burnside from our lab did an amazing job presenting her research on Corynebacterium at the 2025 @asm.org Conference on Biofilms. Molly is applying to PhD programs this fall, and she is going to have a huge amount of success wherever she decides to go! #microbiology #dentistry

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Jonathon L. Baker, Ph.D. @jonbakerlab.bsky.social · 14/11/2025

OHSU was very well represented at the 2025 ASM #Biofilms Conference! #microbiology #dentistry

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Jonathon L. Baker, Ph.D. @jonbakerlab.bsky.social · 18/10/2025

With my colleague Dr. Jens Kreth representing OHSU and the USA at what was a fantastic conference! #microbiology #dentistry #immunology

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Jonathon L. Baker, Ph.D. @jonbakerlab.bsky.social · 13/09/2025

After spending 7 months earlier this year visiting our lab at @ohsunews.bsky.social on a scholarship, Dr. Felipe Farias da Silva recently presented his work with us at the 2025 meeting of the Brazilian Society of Dental Research. Way to go Felipe! #microbiology #dentistry

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Jonathon L. Baker, Ph.D. @jonbakerlab.bsky.social · 21/08/2025

This summer, we hosted Sadie Drucker (Scripps Coll.) and Michelle Lee (Oregon State Univ.), through our NIH-funded DORS program. They did an amazing job, and Sadie won Best Poster at the OHSU Summer Internship Symposium! We wish them the best on the next step in their careers!

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Jonathon L. Baker, Ph.D. @jonbakerlab.bsky.social · 20/08/2025

Microbiology faculty welcoming incoming OHSU President, Dr. Shereef Elnahal, at a celebration for the Knight family’s $2B donation to our university to fight cancer. #microbiology

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Jonathon L. Baker, Ph.D. @jonbakerlab.bsky.social · 16/08/2025

The Baker Lab at OHSU, Summer 2025. 🦠🔬🧫🧪 #microbiology

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Jonathon L. Baker, Ph.D. @jonbakerlab.bsky.social · 28/07/2025

The viral component of the microbiome has been understudied compared to the bacterial component, despite playing a crucial role in both microbial ecology and human health. We also discovered 478 novel species-level viruses. Congratulations to Jonah Tang on his first first-author publication!

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Jonathon L. Baker, Ph.D. @jonbakerlab.bsky.social · 28/07/2025

New publication! We examined the viruses present in the human oral microbiome of children with severe cavities versus healthy teeth and there was a significant difference in the diversity of viruses present in the groups! journals.asm.org/eprint/FDPZ4...

journals.asm.org

The salivary virome during childhood dental caries | mSphere

Dental caries is the most common chronic infectious disease worldwide and is caused by dysbiosis of the oral microbiome featuring an increased abundance of acid-tolerant, acid-producing, and biofilm-f...

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Reposted by Jonathon L. Baker, Ph.D.

ᐯIᑕTOᖇ ᑎIᘔET, ᗰᗪ @nizet.bsky.social · 21/07/2025

If high quality treatment is provided to everyone with bacterial infections + innovative new antibiotics funded ... By 2050: Health costs ⬇️ $97 billion The economy ⬆️ $960 billion Generated health benefits 🟰 $680 billion to countries Return on Investment 🟰 28 to 1 www.cgdev.org/publication/...

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Jonathon L. Baker, Ph.D. @jonbakerlab.bsky.social · 16/06/2025

Excited to see this out! We identified a novel regulator of fatty acid composition in S. pneumoniae (among a lot of other cool stuff in the paper)!

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Jonathon L. Baker, Ph.D. @jonbakerlab.bsky.social · 30/05/2025

The Baker Lab at OHSU, Spring 2025. 🧬🔬🧫🦠 #microbiology

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Jonathon L. Baker, Ph.D. @jonbakerlab.bsky.social · 26/03/2025

Exciting news! Our very first hire, Jonah Tang, was accepted into and will be joining the Bioinformatics Graduate Program at the University of Oregon! After 1.5 years in the lab, Jonah is already an author on 3 submitted publications and several more that are in preparation. Congratulations Jonah!

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Jonathon L. Baker, Ph.D. @jonbakerlab.bsky.social · 11/03/2025

Tomorrow, 1:30pm. AADOCR in NYC. Honored to be a speaker alongside @jmarkwelch.bsky.social and @mbio.bsky.social Editor in Chief Marvin Whiteley. #microbiology #dentistry

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Jonathon L. Baker, Ph.D. @jonbakerlab.bsky.social · 05/03/2025

The Baker Lab was very well represented at OHSU School of Dentistry Research Day! I’m so proud of my team! #microbiology #dentistry

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Jonathon L. Baker, Ph.D. @jonbakerlab.bsky.social · 18/02/2025

Excited to speak at the University of Colorado School of Medicine this Friday! #microbiology

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Reposted by Jonathon L. Baker, Ph.D.

ᐯIᑕTOᖇ ᑎIᘔET, ᗰᗪ @nizet.bsky.social · 10/02/2025

𝗪𝗼𝗿𝘁𝗵 𝗦𝗵𝗮𝗿𝗶𝗻𝗴: 𝗥𝗼𝗹𝗲 𝗼𝗳 𝘁𝗵𝗲 𝗡𝗜𝗛 𝗶𝗻 𝗦𝘂𝘀𝘁𝗮𝗶𝗻𝗶𝗻𝗴 𝘁𝗵𝗲 𝗘𝗰𝗼𝗻𝗼𝗺𝘆 www.unitedformedicalresearch.org/wp-content/u...

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Jonathon L. Baker, Ph.D. @jonbakerlab.bsky.social · 26/01/2025

Happy to share that I was a Finalist for the OHSU 2024 Distinguished Faculty Award in Collaboration! In the last 5 years, collaborated with 83 co-authors from 29 institutions in 9 countries. Congratulations to the other finalists and winner, Dr. Lyndie Foster Page! www.linkedin.com/feed/update/...

linkedin.com

OHSU School of Dentistry on LinkedIn: #dentistry #ohsuschoolofdentistry #ohsudentistry #ohsu #ohsuresearch

Oregon Health & Science University celebrated its 2024 Distinguished Faculty Award winners recently and the OHSU School of Dentistry had a winner and several…

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Jonathon L. Baker, Ph.D. @jonbakerlab.bsky.social · 24/11/2024

A great week at FOP-UNICAMP! We brainstormed ways to get dentists involved in National Action Plans being implemented to combat antibiotic resistance (AMR), showed how to use sequencing to analyze AMR, and also practiced developing grant proposals with the students 🇳🇴🇧🇷🇺🇸

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Jonathon L. Baker, Ph.D. @jonbakerlab.bsky.social · 18/11/2024

In Brazil this week at the Faculdade de Odontologia de Piracicaba with my good friend @AMRTwilight to promote awareness of antimicrobial resistance and antibiotic stewardship. who.int/campaigns/worl…

who.int

World Antimicrobial Awareness Week 2024

World Antimicrobial Awareness Week aims to increase awareness of global antimicrobial resistance (AMR) and to encourage best practices.

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Jonathon L. Baker, Ph.D. @jonbakerlab.bsky.social · 16/11/2024

First start-to-finish, completely in-house RNA-seq in our lab this month, what a time to be alive.

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Jonathon L. Baker, Ph.D. @jonbakerlab.bsky.social · 05/10/2024

Last month I hosted the annual Symposium for our RESISFORCE Project here at @OHSUNews. We hosted 25 researchers from 🇳🇴🇧🇷🇮🇳🇨🇦🇯🇵🇺🇸 to share their research and build collaborations to address the global challenge of #AntimicrobialResistance. Thanks to @forskningsradet for funding!

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