iiinova — where your digital self keeps evolving

JN117 @jn117.bsky.social · 29/07/2026

I wonder if humans have broad enough immunity now that there are no easy gaps in our immunity for a variant to quickly exploit and rise to dominance.

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JN117 @jn117.bsky.social · 17/05/2026

Double check that it still meets your needs. I found that I need more cushion than I did 30 years ago!

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JN117 @jn117.bsky.social · 11/05/2026

Nice visualization. Thank you.

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JN117 @jn117.bsky.social · 28/04/2026

And your companion essay "The 'false-positive PCR' problem is not a problem" was the best ever written on the topic! Many thanks for explaining so clearly. virologydownunder.com/the-false-po...

virologydownunder.com

The "false-positive PCR" problem is not a problem

There clearly is no PCR crisis or false positive plague or casedemic. The false-positive PCR problem is not a problem.

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JN117 @jn117.bsky.social · 24/03/2026

Wastewater disconnect from hospitalization? On Feb 14, wastewater analysis showed very high levels of infection in Minnesota, but there was limited impact on hospitalization for COVID-19. The hospitalization had been falling since December 28. Feb 15 showed 2.1 hospitalizations per 100K per week.

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JN117 @jn117.bsky.social · 18/03/2026

New paper explains a new genetic analysis technique for discriminating direct animal-to-human spillover events versus lab-developed spillover events. Using this analytical approach, SARS-CoV-2 shows no evidence of lab-processing prior to infecting humans. (gift link) www.nytimes.com/2026/03/09/s...

nytimes.com

Scientists Get a Glimpse of How New Pandemics Are Made

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JN117 @jn117.bsky.social · 18/03/2026

Great picture. You should share this during Office Hours!

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JN117 @jn117.bsky.social · 16/03/2026

Mountain climber with LC "I want to share everything I can with others about my story. If there were a fairy that said "30/100 of the M&Ms in that bag are shit pebbles" I wouldn't have even stuck my hand in the bag. I'm the fairy. Avoid COVID. "

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JN117 @jn117.bsky.social · 16/03/2026

I'd be curious to know what your thoughts are. Instead of "safe", I'd probably say "has a good safety record." And instead of "effective", I'd try to quantify the protection--i.e. prevents 80% of hospitalizations, etc.

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JN117 @jn117.bsky.social · 15/03/2026

When it comes to vaccines, the words "safe", "immunity" and "prevent" have caused incredible confusion and sparked endless debates. @kmpanthagani.bsky.social 's recent article does a great job explaining how misunderstandings arise. Recommended! www.youcanknowthings.com/when-work-do...

youcanknowthings.com

When “work” doesn’t work

I recently gave a talk on vaccine communication, and the most common feedback I got was appreciation for the section on words that confuse people. I’ve written before how a lot of “misinformation” ca...

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JN117 @jn117.bsky.social · 10/03/2026

Happy TWiVersary :-) Thanks for letting us listen in on your discussions. I've learned a lot too!

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JN117 @jn117.bsky.social · 10/03/2026

I wish the outcome had been very different. So disappointing.

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JN117 @jn117.bsky.social · 08/03/2026

Either the authors or I am having a malfunction -- I do not see the graphs/figures anywhere in the paper nor on the web site.

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Kristen Panthagani, MD, PhD @kmpanthagani.bsky.social · 02/03/2026

RFK uses many of the same rhetorical tricks over and over again. It’s tempting to play whack-a-mole with every rumor, but research shows a better (and less exhausting) method: “prebunking” — or teaching people to recognize the patterns used to sell falsehoods. Today's post does just that 👇🏽

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Denis - The COVID Info Guy @thecovidinfoguy.bsky.social · 24/02/2026

Australia: "Most flu deaths this century were recorded in 2025, ABS finds" Last Year (2025): 🔹COVID-19: ~2,161 deaths 🔹Influenza: ~1,701 deaths 🔹RSV: ~582 deaths

abc.net.au

Most flu deaths this century were recorded in 2025, ABS finds

There were more deaths associated with influenza last year than any other year this century, according to the Australia Bureau of Statistics.

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JN117 @jn117.bsky.social · 23/02/2026

This was a really cool experiment. Thank you all for this excellent contribution to our understanding! (I've been reading "Air-Borne." It is just fascinating how understanding airborne transmission-- despite it crucial importance to our lives--has not been a greater focus of humanity's efforts.)

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JN117 @jn117.bsky.social · 19/02/2026

Also, the "test negative" approach used in the study might only only detect sequelae that happen at a greater rate for COVID than for other respiratory illnesses. The comparator group all were all being tested for COVID, suggesting they had symptomatic viral illness.

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JN117 @jn117.bsky.social · 19/02/2026

Not sure the study is capable of supporting the authors' conclusions. I don't think medical records ever capture when conditions go away. Probably the study is simply finding that most new Long Covid conditions are first diagnosed in the first year after infection.

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JN117 @jn117.bsky.social · 03/02/2026

Surprisingly comprehensive article on recent research in Nordic countries showing health impacts of COVID-19 on cognitive problems, health care utilization, and rates of depression. www.sciencenorway.no/covid19-long...

sciencenorway.no

Researchers: Not testing for Covid-19 is creating problems

People have become sicker after the pandemic, but without Covid-19 testing it's difficult to understand why.

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JN117 @jn117.bsky.social · 18/01/2026

That is a nice summary. The full research article is here: wwwnc.cdc.gov/eid/article/...

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JN117 @jn117.bsky.social · 16/01/2026

Thank you for explaining this.

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JN117 @jn117.bsky.social · 09/01/2026

Very nice! Did this project require any outside air system (i.e. HRV/ERV)?

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JN117 @jn117.bsky.social · 04/01/2026

I agree. They mention 28-week protection in this press release (which would cover flu season). There were 33 cases (2.8%) of flu in placebo group versus 8 (0.7%) in the CD388 group (450 mg dose). Conceptually, it reminds me of lenacapavir for prevention of HIV. www.cidara.com/news/cidara-...

cidara.com

Cidara Therapeutics Announces Positive Topline Results from its Phase 2b NAVIGATE Trial Evaluating CD388, a Non-Vaccine Preventative of Seasonal Influenza - Cidara Therapeutics

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JN117 @jn117.bsky.social · 04/01/2026

www.cidara.com Cidara Therapeutics is currently in a Phase 3 trial of a long-acting anti-viral against all strains of influenza. In earlier human testing (n=5,000), the preventive medication was 76% effective with a single 450 mg sub-cutaneous dose.

cidara.com

Targeted Immunotherapy for Transformative Outcomes - Cidara Therapeutics

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JN117 @jn117.bsky.social · 04/01/2026

Further in the article, they describe CD388 as "prevents the virus from unclipping , so that the virus is no longer infectious ... by attacking a protein that is essential for replication, the molecule works against every influenza mutation". So it is an anti-viral.

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Chise @sailorrooscout.bsky.social · 28/12/2025

GOOD NEWS! Researchers have shown Alzheimer’s disease can be REVERSED- not just prevented. Using a potent neuroprotective compound called P7C3-A20, they found RESTORING balance to a central cellular energy molecule (NAD+) not only PREVENTED disease features but REVERSED them, EVEN at late stages.

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JN117 @jn117.bsky.social · 17/12/2025

By the way, Bluesky posted recently that they restored access to >18 in MS. bsky.app/profile/bsky...

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JN117 @jn117.bsky.social · 15/12/2025

There is a new HHS web page about Lyme. www.hhs.gov/lyme/index.h...

hhs.gov

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JN117 @jn117.bsky.social · 11/12/2025

There were some unpleasant common side effects. investor.lilly.com/news-release...

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JN117 @jn117.bsky.social · 11/12/2025

Wishing you a speedy full recovery.

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JN117 @jn117.bsky.social · 04/12/2025

you could track it down to a small number of houses or buildings and then seek individual permission to go further. That way it preserves informed consent, if that even applies.

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JN117 @jn117.bsky.social · 04/12/2025

I would want to know. Pemgarda and Paxlovid would then be on my shopping list.

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JN117 @jn117.bsky.social · 01/12/2025

Is COVID "mild"? In a study of 9,000 people who had COVID in 2024, COVID was so "mild" that 24-26% of people had at least one symptom lasting 84 days (fatigue, shortness of breath/respiratory distress, cough, or smell/taste disorder) that they don't have prior. www.shionogi.com/global/en/ne...

shionogi.com

New Clinical Data on the Efficacy of Antiviral Treatments for Post-COVID-19 Condition

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JN117 @jn117.bsky.social · 30/11/2025

The 5 pre-specified symptoms were fatigue, dyspnea or respiratory distress, cough, smell disorder, taste disorder.

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JN117 @jn117.bsky.social · 30/11/2025

Shionogi press release: An observational study found a reduction in incidence of post-COVID condition (PCC) in those who took anti-virals (26% versus 24%). PCC defined as persistence of any of 5 specified symptoms on both days 28 & 84. www.shionogi.com/global/en/ne...

shionogi.com

New Clinical Data on the Efficacy of Antiviral Treatments for Post-COVID-19 Condition

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JN117 @jn117.bsky.social · 19/11/2025

A nice summary article on remission/cures of autoimmune disease in these initial small trials. It seems like various ways of depleting B cells are all working. The article mentions teclistamab, which I was not familiar with. www.medpagetoday.com/rheumatology...

medpagetoday.com

Myeloma Drug Performs Well in Autoimmune Diseases

Safety could be problematic, however

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JN117 @jn117.bsky.social · 14/11/2025

This seems like a significant breakthrough in understanding lupus pathogenesis. It connects EBV infection to the disease. Stanford has licensed the technology to a startup, EBVio Inc, founded by the scientists. med.stanford.edu/news/all-new...

med.stanford.edu

Stanford Medicine scientists tie lupus to a virus nearly all of us carry

The Epstein-Barr virus can convert B cells it’s infected into diabolical overlords that reprogram myriad other immune cells to attack our tissues, Stanford Medicine scientists have found.

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Eric Topol @erictopol.bsky.social · 13/11/2025

Our randomized, placebo-controlled trial of tirzepatide (Zepbound) for #LongCovid has already enrolled 500 participants of 1000 planned in less than 2 weeks! longcovid.scripps.edu/locitt-t/

longcovid.scripps.edu

LoCITT-T - Long COVID Treatment Trial

The Long COVID Treatment Trial-Tirzepatide (LoCITT-T) is investigating the efficacy of repurposing this drug to treat Long COVID.

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JN117 @jn117.bsky.social · 12/11/2025

I do not see the product on sale yet. No pricing was given.

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JN117 @jn117.bsky.social · 12/11/2025

In clinical testing, the RSV test had 94% positive agreement with PCR for subjects within 5 days of symptom onset. www.accessdata.fda.gov/cdrh_docs/re...

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JN117 @jn117.bsky.social · 12/11/2025

Interestingly, the test is licensed for people 6 months and older, so it includes a swab guard to prevent the swab from going deeper than intended.

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JN117 @jn117.bsky.social · 12/11/2025

Unfortunately, no pictures of the actual test cartridge, but the FDA summary of decision shows some diagrams. It has two side-by-side test strips--one with Flu & COVID and the other with RSV. www.accessdata.fda.gov/cdrh_docs/re...

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JN117 @jn117.bsky.social · 12/11/2025

October 27, 2027 -- FlowFlex introduced first US-approved RSV+Flu+COVID home test. Product is made in their new San Diego, CA facility. Press release: www.aconlabs.com/acon-laborat... @danielgriffinmdphd.bsky.social

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