In this Physiology Shorts video, hear from Research Fellow at Imperial College London, Josca Schoonejans, as she takes us behind her paper titled, 'Cardiovascular outcome in 12-month-old male and…

Scientific Reports - Bile acids and ursodeoxycholic acid alter gene expression in primary myometrial cells

Funding is often secured through Wellcome Trust or MRC DTP Fellowships. Further information about this and specific projects studying under the supervision of Departmental supervisors who have obtaine...

Children of mothers with intrahepatic cholestasis of pregnancy (ICP) are more likely to develop metabolic disease later in life. Using a mouse model of gesta...

YouTube video by The Physiological Society

Abstract figure legend Maternal obesity induces systemic inflammation and high insulin and leptin levels, potentially promoting hepcidin release into circulation and thus iron sequestration in specif....

Studies showed that metabolic imbalances during pregnancy in obesity impair the maternal-fetal axis, resulting in fetal growth disturbances with highe…

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Gestational diabetes mellitus (GDM) is a pregnancy complication that can be associated with increased risks of adverse maternal and neonatal outcomes.…

Abstract figure legend This study described the effects of exposure to maternal obesogenic diet and metformin treatment during pregnancy on offspring cardiovascular outcomes. Maternal diet-induced ob...

TikTok video by Tommy’s

Here, a mouse foster nursing model was used to track milk cells in the pup over a period of 21 days. The foster nursing model consisted of wild-type mice fostered by tdTomato+ dams, enabling maternal...

Maternal mortality rates in the US have been increasing steadily over the past decade, with rates significantly increased versus the rest of the developed world, despite the vast healthcare infrastruc...

Women with intrahepatic cholestasis of pregnancy (ICP) have hypercholanemia alongside an increased risk of dyslipidemia. We investigated how cholic acid (CA) supplementation in murine pregnancy impac...

Dr Isadora Clivatti Furigo

Objective Investigation of serum bile acid profiles in pregnancies complicated by gestational diabetes mellitus (GDM) in a multi-ethnic cohort of women who are lean or obese. Design Prospective co.....

Objective and design To determine whether ER stress affects the inhibitory pathways of the human immune system, particularly the immunosuppressive effect of IL-10 on macrophages. Material or subjects ...

Aims/hypothesis Metformin is increasingly used to treat gestational diabetes (GDM) and pregnancies complicated by pregestational type 2 diabetes or polycystic ovary syndrome but data regarding long-te...

Background: Metformin is commonly used to treat gestational diabetes mellitus. This study investigated the effect of maternal metformin intervention during obese glucose-intolerant pregnancy on the go...

The obesity epidemic has led to more women entering pregnancy overweight or obese. In addition to adverse short-term outcomes, maternal obesity and/or gestational diabetes predispose offspring to dev...