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JMCC Plus @jmccplus.bsky.social · 09/02/2026

Stuck between a ROCK2 and a hard place? New research just out shows selective ROCK2 inhibition reduces microvascular obstruction after myocardial I/R but doesn’t limit infarct size. Highlights distinct roles for ROCK isoforms in #cardioprotection. 🫀 www.sciencedirect.com/science/arti... #CardioSky

sciencedirect.com

Selective ROCK2 inhibition reduces microvascular obstruction but does not reduce myocardial infarction after ischaemia and reperfusion

Myocardial ischaemia/reperfusion (I/R) injury causes infarction, microvascular obstruction (MVO), and haemorrhage. MVO, often driven by vasospasm, lac…

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JMCC Plus @jmccplus.bsky.social · 08/01/2026

🫀🦠 How does #COVID19 damage the heart? New research from Gross et al. using human iPSC-derived #cardiomyocytes uncovers cellular responses to SARS-CoV-2, shedding light on mechanisms of cardiac injury. www.sciencedirect.com/science/arti...

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JMCC Plus @jmccplus.bsky.social · 09/12/2025

🚨 New paper alert! Feder et al. have recently shown that persistently increased #CaMKIIδ autophosphorylation drives pathological sarcoplasmic reticulum #calcium loss in a murine model of #doxorubicin-induced #cardiomyopathy. 💔 ➡️📉 Check it out: www.sciencedirect.com/science/arti...

sciencedirect.com

Persistently increased CaMKIIδ autophosphorylation mediates pathologic SR Ca loss in a murine model of Doxorubicin-induced cardiomyopathy

Doxorubicin (DOX)-induced cardiomyopathy (DICM) manifests as left ventricular (LV) systolic dysfunction. DOX triggers oxidative stress and CaMKIIδ act…

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JMCC Plus @jmccplus.bsky.social · 07/11/2025

On your way to #AHA or just looking for some weekend reading? Check out the latest paper from Warren et al who uncovered region-specific metabolic and signalling changes in the endocardium vs epicardium in a mini-pig model of #HCM 🫀🫀 sciencedirect.com/science/arti... #CardioSky #AnimalModel

sciencedirect.com

Signaling pathway alterations in hearts of a porcine model harboring a β-myosin heavy chain (MYH7-R403Q) gene variant

The disease-causing myosin variant (MYH7-403Q) is linked to hypertrophic cardiomyopathy (HCM). We carried out a research study of signaling pathways i…

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JMCC Plus @jmccplus.bsky.social · 03/11/2025

New work from Daoud et al. shows that removal of YAP/TAZ from vascular smooth muscle cells triggers inflammation and immune activation- indicating these factors as essential in vascular health.#vascularbiology sciencedirect.com/science/arti... #CardioSky

sciencedirect.com

YAP/TAZ deletion in vascular smooth muscle cells mirrors atherosclerosis-associated transcriptional programs

The transcriptional co-activators YAP (YAP1) and TAZ (WWTR1) are central regulators of vascular smooth muscle cell (VSMC) phenotype and vascular homeo…

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JMCC Plus @jmccplus.bsky.social · 23/10/2025

New work from Nicole S. York and the group of Leigh Anne Swayne at the University of Victoria charts how #H9c2 heart cells change shape, signal, & express genes during differentiation—revealing both their promise & limits as #cardiomyocyte models. #CardioSky sciencedirect.com/science/arti...

sciencedirect.com

Quantification of morphological, functional, and biochemical features of H9c2 rat cardiomyoblast retinoic acid differentiation

Cell culture models enable advancement in our understanding of heart development and heart disease. The H9c2 rat ventricular cardiomyoblast cell line …

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JMCC Plus @jmccplus.bsky.social · 03/10/2025

Looking for some weekend reading? 📜 New work from from the University of Ottawa Heart Institute, show how metabolic substrates regulate effects of Wnt/β-catenin signaling in #cardiomyocytes, specifically affecting regulation of #Connexin43 sciencedirect.com/science/arti...

sciencedirect.com

Wnt/β-catenin signaling regulates cardiac Cx43 in a metabolic substrate-dependent manner

Both Nav1.5 and Cx43 are critical for the fast electrical impulse conduction in the myocardium and their reductions create the arrhythmogenic substrat…

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JMCC Plus @jmccplus.bsky.social · 12/08/2025

🧬 New pig models of neonatal #HCM show severe cardiac #hypertrophy and perinatal lethality from MYBPC3 and MYH7 mutations. Pigs were highly sensitive to sarcomeric gene disruption, developing severe HCM, suggesting they may not be ideal genetic models. 🔗 www.sciencedirect.com/science/arti...

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JMCC Plus @jmccplus.bsky.social · 08/08/2025

12-week-old #ob/ob mice show mild DCM with no major structural changes in #MAMs. Proteins linked to lipid metabolism and stress response were increased in MAMs, while hypoxic stress triggered more cardiomyocyte death. www.sciencedirect.com/science/arti...

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JMCC Plus @jmccplus.bsky.social · 06/08/2025

Calling all #immunofluorescence scientists! Teng et al. showed glyoxal enhances IF signal and co-localisation while reducing staining artifacts, making it a superior alternative to PFA in murine cardiac tissue research. www.sciencedirect.com/science/arti...

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JMCC Plus @jmccplus.bsky.social · 31/07/2025

📈 Circulating adropin is linked to higher risk of #AKI in patients with acutely decompensated #heartfailure (#ADHF) after decongestive therapy. It outperformed conventional biomarkers like urinary ACR and NT-proBNP. #CardioRenal #Biomarkers www.sciencedirect.com/science/arti...

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JMCC Plus @jmccplus.bsky.social · 29/07/2025

Kazantzi et al show that #MEK–ERK1/2 and #PKC pathways independently and synergistically modulate ETB receptor upregulation under flow cessation. These signalling axes may be promising targets for #cerebrovascular disease. Read more here! www.sciencedirect.com/science/arti...

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JMCC Plus @jmccplus.bsky.social · 26/06/2025

NIH-funded and need to publish in an open-access journal? JMCC Plus is fully OA and we're offering a 50% APC discount until 30 Sept 2025! Submit your work and join our growing community of cardiovascular researchers. #OpenAccess #Cardiac #Research www.sciencedirect.com/journal/jour...

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JMCC Plus @jmccplus.bsky.social · 23/06/2025

New in JMCC Plus: This study presents a multidimensional analysis to investigate culture-induced alterations in living #myocardial slices, demonstrating structural integrity despite changes to slices’ functional and #molecular profiles Read more here! www.sciencedirect.com/science/arti...

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JMCC Plus @jmccplus.bsky.social · 20/06/2025

Exciting news! Clarivate has released the inaugural #ImpactFactor for 2024, and JMCC Plus, just 3 years since its launch, has earned a spot in Q2! A huge thank you to our authors, reviewers, and readers for helping us reach this milestone. #AcademicPublishing #JMCCPlus

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JMCC Plus @jmccplus.bsky.social · 16/06/2025

Heart failure alters organelle dynamics. Latchman et al. reveal striking shifts in failing cardiomyocytes- more rounded #mitochondria, disrupted SR-mitochondria juxtaposition and altered lipid droplet size across #heart #failure types . www.sciencedirect.com/science/arti... ‪@upenn.edu @temple.edu‬

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JMCC Plus @jmccplus.bsky.social · 11/06/2025

New #CardioBreakthrough: Gemfibrozil—beyond lipid-lowering—blocks caspase‑11‑driven pyroptosis in mouse hearts, reducing infarct size during ischemia/reperfusion. A promising repurposed therapy post-#AMI! Congratulations to all authors. Want to know more?

sciencedirect.com

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JMCC Plus @jmccplus.bsky.social · 12/05/2025

The JMCC and JMCC Plus Reception is in full swing at #ISHR World Congress 2025! A great opportunity to bring our editorial team and reviewers together, while hearing from JMCC #EiC Rong Tian and JMCC Plus #EiC @davorpavlovic.bsky.social

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JMCC Plus @jmccplus.bsky.social · 12/05/2025

The 25th World Congress of #ISHR 2025 in Nara, Japan, has officially begun with over 1000 members attending! A fantastic start to the conference, welcomed by traditional Japanese music, before hearing from this years' ISHR awardees. @ishr-aus.bsky.social

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JMCC Plus @jmccplus.bsky.social · 09/05/2025

Looking for some weekend reading or on your way to the ISHR meeting in Japan? Check out the recent work from Alican Guran, @k8weeks.bsky.social et al. investigating the role of B56α as a mediator of cardiac responses to β-AR stimulation! sciencedirect.com/science/arti...

sciencedirect.com

PP2A-B56α is a key determinant of cardiac protein phosphorylation and functional responses to β-adrenergic signalling

B56α is a protein phosphatase 2 A (PP2A) regulatory subunit which modulates the heart's inotropic response to acute β-adrenergic receptor (β-AR) stimu…

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JMCC Plus @jmccplus.bsky.social · 31/03/2025

A recent study found that women undergoing cardiac surgery show reduced CD39/CD73 expression and greater #fibrosis. Using a #CD39 mimetic and #CD73 enhancer improved cardiac function and reduced fibrosis in an ovariectomy + high-fat diet mouse model. Read more: www.sciencedirect.com/science/arti...

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JMCC Plus @jmccplus.bsky.social · 21/03/2025

New Paper Alert! New work just published investigated the differences in the #electrophysiology of the left and right stellate ganglia What repercussions may this have for #Arrhythmia generation? Congrats to the Authors and thanks to the Reviewers! sciencedirect.com/science/arti... #CardioSky

sciencedirect.com

Electrophysiological comparison of left versus right stellate ganglia neurons

The stellate ganglia of the peripheral autonomic nervous system innervate the heart and continuously fine-tune cardiac function to meet physiological …

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JMCC Plus @jmccplus.bsky.social · 12/02/2025

Exciting news! Join us for another exclusive ISHR-ES webinar: The Beating Edge of Cardiac Metabolism! 🫀💡 📅 Friday, 7th March 2025 | ⏰ 14:00 to15:00 GMT + 1| 💻 Live Online Hear from three leading experts as they dive into cutting-edge research & innovations. 🔗 Register now: buff.ly/4aWIbv1

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JMCC Plus @jmccplus.bsky.social · 03/02/2025

New research by Grazide and colleagues has revealed a novel biomarker for myocardial infarction risk. Rubicon, a negative regulator of autophagy, could aid in the early detection of individuals at high risk for MI Read more here: buff.ly/3WyWO1i

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JMCC Plus @jmccplus.bsky.social · 30/01/2025

We are delighted to share that JMCC Plus is now officially indexed in PubMed Central (PMC)! Well done to all the editorial team, particularly our EiC @davorpavlovic.bsky.social and deputy @gundrylab.bsky.social 🎉

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JMCC Plus @jmccplus.bsky.social · 20/01/2025

Can we predict survival after #CardiogenicShock? New research from researchers at Helsinki University and the Luxembourg Institute of Health show that a particular miRNA (miR-20b-5p) is associated with survival in cardiogenic shock! #CardioSky

sciencedirect.com

Circulating levels of miR-20b-5p are associated with survival in cardiogenic shock

Cardiogenic shock (CS) is a medical emergency with high in-hospital mortality. New biomarkers are needed to identify patients at a greater risk of adv…

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JMCC Plus @jmccplus.bsky.social · 24/12/2024

Wishing everyone Happy Holidays from the #JMCCPlus team! 2024 has been a great year for the journal, but wouldnt have been possible without the hard work of the editors, reviewers, authors and readers, so thanks! Looking forward to what #2025 brings! #CardioSky

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JMCC Plus @jmccplus.bsky.social · 20/12/2024

We are pleased to have recently published the abstracts from both the ISHR_ES and ISHR-Southeast Asia meetings.. Interested in the latest work presented there? Check out the following links! sciencedirect.com/journal/jour... sciencedirect.com/journal/jour... #CardioSky

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JMCC Plus @jmccplus.bsky.social · 18/12/2024

In our December issue, fantastic research by Jiang et al. highlights how perivascular #fibrosis in intramyocardial blood vessels may play a key role in #myocardialinfarction (#MI) progression. Read more here: www.sciencedirect.com/science/arti...

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JMCC Plus @jmccplus.bsky.social · 11/12/2024

Congratulation to the authors on this great piece of work just published in our journal! Learn more about it in the thread below from @dr-yktham.bsky.social

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