iiinova — where your digital self keeps evolving

Jihane Basbous @jihanebasbous.bsky.social · 26/08/2026

Thrilled to share a preprint from a collaborative project with M Stucki’s team. We uncover a 2-component mechanism in which chromatin adaptors provide molecular specificity while TOPBP1 condensates organize and sustain ATM signaling at sites of DNA damage doi.org/10.64898/2026.08.21.746129

doi.org

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Jihane Basbous @jihanebasbous.bsky.social · 01/08/2026

Thrilled to share our new preprint showing that TopBP1 condensates orchestrate nuclear actin remodeling during replication stress, thereby linking stress signaling, nuclear envelope organization, and genome stability. Led brilliantly by our former PhD student Elia Moarbess ! lnkd.in/g4UFD_MM

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Reposted by Jihane Basbous

Andrea Musacchio @andrea-musacchio.bsky.social · 04/12/2025

Give the laurels to the one who earned them. A thread that aims to attribute credits to the originators of important ‘firsts’ This is on the making. Please contribute to accurate historical records with comments and reading recommendations 🧵👇

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Reposted by Jihane Basbous

Cláudio Gomes Lab - Protein Misfolding in Disease @claudiogomeslab.bsky.social · 01/06/2025

📢 International Symposium on Protein Interactions and Self-Assembly Join us in ☀️ Lisbon 🇵🇹 🗓️ 14–16 July 2025 🗣️ A great programme + short talks selected from abstracts. 🔗 Check it here: twin2pipsa.campus.ciencias.ulisboa.pt/ISPIS2025.html 🔬 Powered by #TWIN2PIPSA at @cienciasulisboa.bsky.social

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Jihane Basbous @jihanebasbous.bsky.social · 16/05/2025

Our latest work "TopBP1 biomolecular condensates: a new therapeutic target in advanced-stage colorectal cancer" led by Laura Morano, is now out in @eLife! Huge thanks to our collaborators at IGH and IRCM. And a special thought goes to Angelos Constantinou. 🙏 doi.org/10.7554/eLif...

doi.org

TopBP1 biomolecular condensates: a new therapeutic target in advanced-stage colorectal cancer

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Reposted by Jihane Basbous

Lopes_Lab @lopeslab.bsky.social · 07/05/2025

Exciting PhD project available in our lab (time sensitive)! 👇

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Reposted by Jihane Basbous

Andrew Deans @genomestability.bsky.social · 25/04/2025

FANCX=FAAP100, new Fanconi Anemia gene Two new papers identify 3 families with FAAP100 homozygous mutations leading to severe developmental and hematologic abnormalities leading to death in utero or in early life. www.jci.org/articles/vie... www.jci.org/articles/vie...

jci.org

JCI - Genetic inactivation of FAAP100 causes Fanconi anemia due to disruption of the monoubiquitin ligase core complex

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Reposted by Jihane Basbous

Vincenzo Costanzo @labvincenzo.bsky.social · 17/01/2025

Join the first Keystone conference dedicated to DNA replication gaps and cancer! Send an abstract to be selected for a talk. www.keystonesymposia.org/conferences/...

keystonesymposia.org

DNA Replication Gaps, Cancer and Disease | Keystone Symposia

Join us at the Keystone Symposia on DNA Replication Gaps, Cancer and Disease, April 2025, in Daejeon, with field leaders!

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Jihane Basbous @jihanebasbous.bsky.social · 04/12/2024

Dear Colleagues, We are extending our early bird registration deadline to December 17th as there have been some issues both with the Carte Achat service as well as with the website. All have now been sorted.We look forward to seeing you for this special event that will honour the memory of Angelos.

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