ALT: a cartoon character says to shreds you say while talking on a cell phone

Trump news at a glance: president says Democrats should be arrested for ‘seditious behavior’, drawing outrage

The Council of the Inspectors General on Integrity and Efficiency is funded largely through a no-year revolving account, rather than the regular appropriations that lapsed Oct. 1.

3 teens injured in Colorado high school shooting, including suspected shooter

Through a synthetic-bioinformatic natural product approach combined with peptide optimization, a nature inspired antibiotic, paenimicin, was identified from Paenibacillaceae family. Paenimicin feature...

ALT: a cartoon of a dog holding a basket of food with the words this never ends

Ageing populations worldwide face increasing challenges of multimorbidity (that is, the co-occurrence of two or more chronic conditions). The combination of chronic kidney disease (CKD) and dementia occurs more frequently than it would by simple coincidence, owing to several underlying biological and clinical mechanisms. Population-based cohort studies are an important epidemiological tool and have contributed to improved understanding of these mechanisms. These mechanisms include uniquely shared haemodynamic features of vasculature, overlapping risk factor profiles, and direct neurotoxic effects of accumulating waste products due to poor kidney function. The effect of these pathways is suggested to differ across gender, relevant demographic subgroups, and populations from low- to middle-income countries. Yet, given their study design, population-based cohort studies also inherently face several methodological challenges. These challenges pertain to the use of biomarkers that do n