In a model of pancreatic ductal adenocarcinoma, extrachromosomal DNAs are shown to be a source of high-level focal amplification driving MYC heterogeneity and phenotypic adaptation.

Main Finding: High-grade osteosarcomas frequently exhibit a loss–translocation–amplification (LTA) pattern of chromothripsis that inactivates TP53 and amplifies oncogenes.Concept: Ongoing chromothrips...

Un equipo de científicos revela el mecanismo del osteosarcoma, un tumor que se extiende desde los huesos: “Hay cromosomas que son como Frankenstein”

Study identifies a novel mechanism driving osteosarcoma and provides insights to help predict patient outcomes.

Find people followed by the people you follow, but who you don't follow, using R and the atrrr package

We provide open data that helps scientists understand life and that informs solutions to real-world problems, such as infectious diseases, climate change and food security.

Studying in Lisbon, I found most of my peers were planning to emigrate. Now the government is turning to taxes to stop the brain drain In the autumn of 2018, I moved to Lisbon for a month-long course at the Universidade de Lisboa. I struggled to find any…

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