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Jérôme Salignon

@jeromesalignon.bsky.social
16 followers 95 following 12 posts
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Reposted by Jérôme Salignon
Aging Science News @agingbiology.bsky.social · 04/08/2026
Pasta, a Versatile Transcriptomic Clock, Maps the Chemical and Genetic Determinants of Aging and Rejuvenation advanced.onlinelibrary.wiley.com/doi/10.1002/...
advanced.onlinelibrary.wiley.com
Pasta, a Versatile Transcriptomic Clock, Maps the Chemical and Genetic Determinants of Aging and Rejuvenation
Pasta is a transcriptomic aging clock built on an age-shift learning framework and trained on 17 000 samples across 21 datasets. It accurately predicts relative biological age across tissues, platfor....
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Jérôme Salignon @jeromesalignon.bsky.social · 09/06/2025
Can we measure & shift a cell’s age? Meet Pasta, a plug-and-play transcriptomic clock that flags perturbations that ↑ (cancer therapy) or ↓ (regenerative medicine) biological age. doi.org/pqhh bsky.app/profile/jero...
doi.org
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Jérôme Salignon @jeromesalignon.bsky.social · 09/06/2025
Can we measure & shift a cell’s age? Meet Pasta, a plug-and-play transcriptomic clock that flags perturbations that ↑ (cancer therapy) or ↓ (regenerative medicine) biological age. doi.org/pqhh #aging #AI 🧵 bsky.app/profile/jero...
doi.org
Pasta, an age-shift transcriptomic clock, maps the chemical and genetic determinants of aging and rejuvenation
As the prevalence of age-related diseases rises, understanding and modulating the aging process is becoming a priority. Transcriptomic aging clocks (TACs) hold great promise for this endeavor, yet mos...
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Jérôme Salignon @jeromesalignon.bsky.social · 09/06/2025
Can we measure & shift a cell’s age? Meet Pasta, a plug-and-play transcriptomic clock that flags perturbations that ↑ (cancer therapy) or ↓ (regenerative medicine) biological age. doi.org/pqhh #aging #AI 🧵 bsky.app/profile/jero...
doi.org
Pasta, an age-shift transcriptomic clock, maps the chemical and genetic determinants of aging and rejuvenation
As the prevalence of age-related diseases rises, understanding and modulating the aging process is becoming a priority. Transcriptomic aging clocks (TACs) hold great promise for this endeavor, yet mos...
000
Jérôme Salignon @jeromesalignon.bsky.social · 05/06/2025
Can we measure & shift a cell’s age? Meet Pasta, a plug-and-play transcriptomic clock that flags perturbations that ↑ (cancer therapy) or ↓ (regenerative medicine) biological age. doi.org/pqhh #aging #AI 🧵👇
clock face built from pasta shapes with Vitruvian-man—logo for Pasta transcriptomic ageing clock.
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Reposted by Jérôme Salignon
Floris Barthel @florisbarthel.bsky.social · 16/04/2025
🚨 Pre-print alert! 🚨 We generated chromosome-scale diploid genome assemblies for the widely used fibroblast lines BJ and IMR-90. These models of replicative senescence and telomere shortening now have fully resolved telomeres, subtelomeres, and centromeres. 🧬 🧵👇
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Reposted by Jérôme Salignon
Prof Claire Hills @chillslincoln79.bsky.social · 23/11/2024
Emerging insights in senescence: pathways from preclinical models to therapeutic innovations 👩‍🔬🧪🔬🥼👨‍🔬 #senescence #SASP #ageing #inflammation #NephSky #CardioSky #Senescent Full details 👇 ✨️ www.nature.com/articles/s41...
nature.com
Emerging insights in senescence: pathways from preclinical models to therapeutic innovations - npj Aging
npj Aging - Emerging insights in senescence: pathways from preclinical models to therapeutic innovations
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