iiinova — where your digital self keeps evolving

Jenn Sydeski 🧬 📈 🩺 ⛑️ @jennifersydeski.com · 13/05/2026

I'm not super worried about #Hanta virus atm. Like many, I am more generally concerned about national leadership in this space, so I'm grateful for state and local/county level #publichealth folks doing good work.

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Jenn Sydeski 🧬 📈 🩺 ⛑️ @jennifersydeski.com · 27/04/2026

Hey friends! Here's a fun and happy story to start your week! ⛑️I'm in the Medical Reserve Corps, which 🧵 💙 Quick thanks to @americanheart.bsky.social, @guinnessworldrecords.com, @acrisurestadium.bsky.social, @hamlinisland.bsky.social, #DoctorMike, #NFLDraft, & the awesome volunteers & participants!

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Jenn Sydeski 🧬 📈 🩺 ⛑️ @jennifersydeski.com · 07/12/2025

Doing a year-in review and looking for something totally else, but just found one of my favorite podcast experiences from back in my #ConnectWolf days with Mitch Turck 😍 share.transistor.fm/s/2b920ea3

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Jenn Sydeski 🧬 📈 🩺 ⛑️ @jennifersydeski.com · 11/08/2025

$100 to be a tech investor 💫 Or more for bigger perks! 🌈 Brad and I at @ektovr.bsky.social are inviting our community to join in as an EKTO investor before our big consumer launch at #PAX this month 🩵

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Jenn Sydeski 🧬 📈 🩺 ⛑️ @jennifersydeski.com · 21/05/2025

TL;DR 💙 Touchin grass n'at 🌿 Toodles! ✌️ 🧵@pittsburghai.bsky.social L;R Thanks for doing stuff with me! PGH.AI’s off to a strong repeatable start, Sheetz inno-infrastructure is deployed and we just got some major innovation props, @ektovr.bsky.social's commercialization launch is set up and running,

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Jenn Sydeski 🧬 📈 🩺 ⛑️ @jennifersydeski.com · 19/05/2025

Personalized ctDNA testing shows promise in detecting minimal residual disease in metastatic invasive lobular carcinoma, offering a potential tool for early relapse detection and treatment monitoring. ascopubs.org/doi/10.1200/...

1. Feasibility of Personalized ctDNA Testing: The study demonstrates that personalized ctDNA assays can be developed and are feasible for monitoring metastatic ILC.

2. Early Detection of Relapse: ctDNA levels were found to rise before clinical or radiographic evidence of disease progression, indicating potential for early relapse detection.

3. Correlation with Treatment Response: Changes in ctDNA levels correlated with treatment responses, suggesting utility in monitoring therapeutic efficacy.

4. Potential for Personalized Monitoring: This approach underscores the potential of ctDNA testing as a personalized tool for disease monitoring in metastatic ILC patients.

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Jenn Sydeski 🧬 📈 🩺 ⛑️ @jennifersydeski.com · 17/05/2025

AI-driven research reveals that the enzyme PHGDH, beyond its known metabolic role, acts as a transcriptional regulator promoting amyloid pathology in Alzheimer's disease. Targeting this function offers a promising therapeutic avenue. www.cell.com/cell/fulltex...

1. PHGDH's Dual Role: Traditionally recognized for its metabolic functions, PHGDH also regulates gene expression, influencing Alzheimer's disease progression.

2. AI-Powered Discovery: Utilizing AI, researchers identified PHGDH's structural similarity to transcription factors, unveiling its unexpected role in gene regulation.

3. Therapeutic Potential: Inhibiting PHGDH's transcriptional activity with a blood-brain barrier-permeable molecule reduced amyloid pathology in preclinical models.

4. Beyond Genetic Mutations: This finding highlights a non-genetic contributor to Alzheimer's, offering new hope for treatments targeting sporadic cases.

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Jenn Sydeski 🧬 📈 🩺 ⛑️ @jennifersydeski.com · 16/05/2025

In a world-first, doctors used CRISPR to correct a deadly genetic mutation inside a baby's liver, offering hope for treating rare diseases with personalized gene editing. www.npr.org/sections/sho...

1. First In-Body CRISPR Treatment: Doctors successfully edited DNA inside a living patient, a baby with CPS1 deficiency, marking a significant medical milestone.

2. Rapid Development: The custom therapy was developed and approved in just six months, showcasing the potential for swift responses to rare genetic conditions.

3. Improved Health Outcomes: Post-treatment, the baby showed remarkable health improvements, including better protein tolerance and immune response.

4. Future of Personalized Medicine: This case paves the way for bespoke gene-editing therapies, potentially transforming treatment for countless rare genetic disorders.

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Jenn Sydeski 🧬 📈 🩺 ⛑️ @jennifersydeski.com · 14/05/2025

The #FDA is rapidly implementing #AI across all centers by June 30, 2025, following a successful pilot that enhanced scientific review efficiency, aiming to expedite therapy evaluations and reduce administrative burdens. How do we feel about this? oncodaily.com/insight/fda-...

1. Agency-Wide AI Integration: The FDA plans to deploy a unified, secure generative AI system across all centers by June 30, 2025, to streamline internal workflows.

2. Efficiency Gains from Pilot: A recent AI pilot demonstrated significant improvements in scientific review processes, prompting the accelerated rollout.

3. Leadership Endorsement: FDA Commissioner Martin Makary emphasized the importance of valuing scientists' time and reducing non-productive tasks through AI.

4. Focus on Therapeutic Acceleration: The initiative aims to expedite the evaluation of new therapies, benefiting patients by bringing treatments to market more swiftly.

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Jenn Sydeski 🧬 📈 🩺 ⛑️ @jennifersydeski.com · 13/05/2025

Scientists have developed a non-invasive method to 3D print tissues inside the body using ultrasound and a special bioink, eliminating the need for surgery and opening new avenues for internal tissue repair and drug delivery. singularityhub.com/2025/05/12/s...

1. Ultrasound-Activated Bioink: A new bioink remains liquid at body temperature but solidifies into desired structures when exposed to focused ultrasound, enabling precise internal tissue formation.

2. Non-Invasive Internal Printing: This technique allows for the creation of tissues, biosensors, and drug depots directly inside organs without surgical intervention, reducing risks and recovery time.

3. Real-Time Monitoring: The bioink includes components that respond to ultrasound, allowing scientists to monitor the printing process in real-time and ensure accurate placement.

4. Versatile Applications: Beyond tissue repair, this method has potential uses in targeted drug delivery and the creation of internal biosensors, marking a significant advancement in regenerative medicine.

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Jenn Sydeski 🧬 📈 🩺 ⛑️ @jennifersydeski.com · 13/05/2025

Researchers detected #measles virus in Houston #wastewater in early January 2025, ten days before clinical cases were reported, demonstrating wastewater sequencing as a powerful #earlywarning tool for #infectiousdisease #outbreaks. ajph.aphapublications.org/doi/epdf/10....

1. Early Detection via Wastewater Sequencing: Measles virus was identified in wastewater samples on January 7, 2025, preceding confirmed clinical cases by ten days, showcasing the potential of wastewater surveillance for early outbreak detection.

2. High Sensitivity and Specificity: The sequencing-based method proved highly sensitive, detecting measles RNA in wastewater where no cases had been reported for over 31 months, and was validated through PCR testing.

3. Correlation with Clinical Cases: The presence of measles in wastewater corresponded with two infected travelers residing in the area, indicating the method's effectiveness in reflecting real-time community infections.

4. Public Health Implications: This approach offers a non-invasive, community-wide surveillance tool that can inform public health responses and interventions ahead of clinical case confirmations.

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Jenn Sydeski 🧬 📈 🩺 ⛑️ @jennifersydeski.com · 12/05/2025

Political shifts in the U.S. are threatening mRNA research, with funding cuts and anti-vaccine sentiments endangering advancements in cancer, HIV, and rare disease treatments. www.nature.com/articles/d41...

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Jenn Sydeski 🧬 📈 🩺 ⛑️ @jennifersydeski.com · 12/05/2025

New data shows the shingles vaccine may reduce dementia risk by up to 20%, especially in women. While the exact mechanism is unclear, the immune response to vaccination appears protective. A promising twofer: prevent shingles and lower dementia risk. erictopol.substack.com/p/the-shingl...

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Jenn Sydeski 🧬 📈 🩺 ⛑️ @jennifersydeski.com · 20/03/2025

Happy Spring ☔🌱🌸🌷 The Northern hemisphere will start tilting towards the Sun! ☀️

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Jenn Sydeski 🧬 📈 🩺 ⛑️ @jennifersydeski.com · 13/03/2025

FDA just cleared the ReWalk 7, the latest in Lifeward’s lineup of wearable exoskeletons for spinal cord injury. More features, more accessibility, and backed by Medicare. #MedTech www.globenewswire.com/news-release/…

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Jenn Sydeski 🧬 📈 🩺 ⛑️ @jennifersydeski.com · 11/03/2025

I missed it by a few minutes, but my buddy and I celebrated by hitting up an arcade for half an hour and watching some Gaming Historian videos 🎮🕹️ Happy Mar10 Day 😘

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Jenn Sydeski 🧬 📈 🩺 ⛑️ @jennifersydeski.com · 09/03/2025

Neffy is an epinephrine nose spray for allergic reactions like anaphylaxis and just got approved by the FDA for kids 💊💉💦 www.pharmacytimes.com/view/fda-appr…

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Jenn Sydeski 🧬 📈 🩺 ⛑️ @jennifersydeski.com · 09/03/2025

Fully basking in fake spring despite the fact that winter is waiting around the corner with a baseball bat 🤣 I love seasons because after a few weeks, I'm ready for a change in the vibe.

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Jenn Sydeski 🧬 📈 🩺 ⛑️ @jennifersydeski.com · 09/03/2025

Reading this book about the situation at Twitter after Elon Musk purchased it, and finding it's really insightful about what's happening right now in the US government.

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Jenn Sydeski 🧬 📈 🩺 ⛑️ @jennifersydeski.com · 08/03/2025

Standing up for science in Pittsburgh sometimes involves sitting down. #Accessibility #Pittsburgh #Pitt #CMU

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Jenn Sydeski 🧬 📈 🩺 ⛑️ @jennifersydeski.com · 06/03/2025

Ember on her throne, otherwise known as the pup-asan chair.

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Jenn Sydeski 🧬 📈 🩺 ⛑️ @jennifersydeski.com · 06/03/2025

My nerdling's first protest was the March for Science in 2017, and now we're talking about how real change takes time. Two steps forward, one step back. #BeTheHelpers

Pittsburgh Science March 3-7-2025 11am Schenley Plaza

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Jenn Sydeski 🧬 📈 🩺 ⛑️ @jennifersydeski.com · 24/02/2025

Take breaks, friends. You are not alone, but part of mighty movements and communities. 🩵 We are more powerful as a group than as many individuals, because of the benefits of the collective. You are not obligated to complete the work, but neither are you free to desist from it (Pirkei Avot 2:21)

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Jenn Sydeski 🧬 📈 🩺 ⛑️ @jennifersydeski.com · 19/02/2025

Yes! Sharing screenshots for simplicity, but or links and discussions, I posted these over the last few days so just scroll down my page 🩵

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Jenn Sydeski 🧬 📈 🩺 ⛑️ @jennifersydeski.com · 19/02/2025

Today, I introduced myself in a new way—focusing on what I do uniquely well, not just where I’ve been and what I've done. It was awkward, imperfect… and a win. Growth is messy, but clarity comes with practice. Try the hard thing. Say it out loud. Refine as you go. You’ll get there.

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Jenn Sydeski 🧬 📈 🩺 ⛑️ @jennifersydeski.com · 18/02/2025

Eddie is the only one still awake on this Three Dog Night 🐕🐕🐕

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Jenn Sydeski 🧬 📈 🩺 ⛑️ @jennifersydeski.com · 24/01/2025

My favorite thing I get to mute to eliminate from my feed is "football" 😍 You can mute a word, so topics that you don't care about or need a break from are less likely to be in your feed. What are you excited to mute? 🌿

Screenshot to illustrate moderation location

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Jenn Sydeski 🧬 📈 🩺 ⛑️ @jennifersydeski.com · 17/01/2025

Shadow has been so gruntled this week in Pittsburgh 🤣❄️ #winter #huskymix #home

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Jenn Sydeski 🧬 📈 🩺 ⛑️ @jennifersydeski.com · 15/01/2025

Hi friends! I'm looking for a strategic leadership role in health technology, life sciences, and adjacent industries. More about me at www.jennifersydeski.com or feel free to DM ⭐ 🧬 🧪 🤖 🩻 ⚕️ 💉 💊 🩸 📊 🩺 🫀 📱 🔬 ⚙️ 🚑 ❤️‍🩹 🏥 🦴 🧠 🩹 🩼 💻 💡 🧫 🧪 ⚗️ 🏢 📈 #JobHunt #JobSearch #OpenToWork #Med #Bio #Tech #Science

Resume of Jenn Sydeski - read more at https://www.linkedin.com/in/jenniferlynsydeski/

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Jenn Sydeski 🧬 📈 🩺 ⛑️ @jennifersydeski.com · 09/01/2025

Ember is so sleepy. #Hygge vibes tonight. Thinking about the vital core components of genuine #community and how to identify when one of those is at risk.

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Jenn Sydeski 🧬 📈 🩺 ⛑️ @jennifersydeski.com · 06/01/2025

My mum has been in the hospital for weeks. They keep making communication errors that impact her health and delay recovery. Today is a rough day, and I'm working from home while my partner provider-wrangles. I see gaps to solve. My laptop looks a little sus tho. #PatientAdvocacy #Healthcare #Tech

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