Reposted by Jeffrey Townsend
In his Int J Cancer editorial, @jeffreytownsend.bsky.social cautions that a pan-cancer co-mutation map can reflect tissue. Vaeyens et al. published their data, so we re-ran their BRAF/KRAS/EGFR calls within tumour types and against chance. Textbook exclusions hold; no co-occurrence does.
![Top 10 gene-wide cancer effects in colon and rectal adenocarcinoma plus cancer effects for the six genes previously identified as “private”. Genes are sorted by the cross-cohort maximum, and those identified by De Angelis et al. [1] are in boldface. *: Rectal adenocarcinoma effects are shift-aligned to the colon adenocarcinoma cohort scale](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:cqduu3mqruibnzbzdkz65rhx/bafkreifxo6gsbh5eky7gy3f3ijeq3f2fes3qqewjgds7s4cqvj4x6buq2m)
![Gene-wide cancer effects in colon and rectal adenocarcinoma. Gene-level cancer effect estimates (grey circles) aggregate selection across all observed variants within a gene, including those nominated by by De Angelis et al. [1] (colored circles); and shift-aligned parity (dashed line) after correcting the global colon and rectal adenocarcinoma scale difference](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:cqduu3mqruibnzbzdkz65rhx/bafkreigzpy5o3a6ioxmrktj73zebvnzoejljzy4wbl2kmf5pxyeaq6px3y)
