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Jeff Lee

@jeffleelab.bsky.social
54 followers 69 following 4 posts

Wellcome Early-Career Fellow | RNA Biologist | Motor neuron disease | University of Glasgow

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Reposted by Jeff Lee
Matthew Taliaferro @jmtali.bsky.social · 11/06/2026
New paper! How do RNAs "know" where to go inside a cell? We dug into the sequence elements that route RNAs to the right place. It turns out that, in mammals, they're surprisingly massive (>200 nt), multipartite, and wonderfully complicated. 🧵
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Reposted by Jeff Lee
Alfredo Castello @alf-castello.bsky.social · 04/04/2026
Proud of Louisa Iselin. Not the easiest PhD, covid, two supervisors (shabazlab.bsky.social) moving labs, but she pushed through and delivered a really solid piece of work on how interferon reshapes RNA-protein interactions post-translationally www.cell.com/cell-reports...
cell.com
RNA binding as an emerging regulatory dimension in the type I IFN response
Iselin et al. explore how the type I IFN response regulates RNA-binding activity using RNA-interactome capture and extend the RIC protocol to assess the role of phosphorylation in this process. Focusi...
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Reposted by Jeff Lee
Matthew Taliaferro @jmtali.bsky.social · 15/12/2025
Excited to share that this work is now published in its final form! link.springer.com/article/10.1...
link.springer.com
TDP-43 directly inhibits mRNA accumulation in neurites through modulation of mRNA stability - The EMBO Journal
The subcellular localization of many mRNAs to neuronal projections allows neurons to efficiently and rapidly react to spatially restricted external cues. However, for most of these RNAs, the mechanism...
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Reposted by Jeff Lee
Alfredo Castello @alf-castello.bsky.social · 03/06/2025
🚨🚨 News from the @castello-lab.bsky.social and @shabazlab.bsky.social. Our work, led by Louisa Iselin, reveals pervasive changes in the RNA-bound proteome induced by interferon. #RNA, #immunity, #interferon, #host-virus www.biorxiv.org/content/10.1...
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Reposted by Jeff Lee
Matthew Taliaferro @jmtali.bsky.social · 03/03/2025
Excited to share our latest work! We asked if and how TDP-43 regulates RNA transport in neurons and if this is misregulated in ALS. We found that it works to keep RNAs *out* of neurites, and that loss of TDP-43 activity results in specific RNAs aberrantly accumulating there.
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Reposted by Jeff Lee
Alfredo Castello @alf-castello.bsky.social · 17/02/2025
Amazing work of our dear friends @ilandavis.bsky.social and @jeffylee.bsky.social characterising the interlinked roles of two key RBPs in drosophila brain development, congratulations 🍾🥂🎉🎉🎉 www.science.org/doi/10.1126/...
science.org
Imp/IGF2BP and Syp/SYNCRIP temporal RNA interactomes uncover combinatorial networks of regulators of Drosophila brain development
RNA binding protein combinations control neuronal identity through a network of temporal regulators.
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Reposted by Jeff Lee
Ilan davis @ilandavis.bsky.social · 12/02/2025
Jeff Lee et al paper from my lab is out now www.science.org/doi/10.1126/... I am very grateful to Jeff, Nile's and Tamsin for all the hard work on this tour de force paper. Jeff deserves more credit than me for masterminding it and the outstanding data analysis: 2 RBPs over 3 developmental times.
science.org
Imp/IGF2BP and Syp/SYNCRIP temporal RNA interactomes uncover combinatorial networks of regulators of Drosophila brain development
RNA binding protein combinations control neuronal identity through a network of temporal regulators.
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Jeff Lee @jeffleelab.bsky.social · 10/02/2025
Following our recent publication, here’s a striking collage of developing fly brain! 🧠✨ Highlighting the dynamic expression of RNA-binding proteins Imp (green) and Syp (magenta) www.science.org/doi/10.1126/...
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Jeff Lee @jeffleelab.bsky.social · 10/02/2025
🧠🔬How do RNA-binding proteins shape brain development? Our latest study reveals how Imp & Syp form combinatorial networks to regulate Drosophila neurogenesis. Excited to share this work in #ScienceAdvances! 📜 Read more: www.science.org/doi/10.1126/... #ilandavislab #RNA #neurogenesis
science.org
Imp/IGF2BP and Syp/SYNCRIP temporal RNA interactomes uncover combinatorial networks of regulators of Drosophila brain development
RNA binding protein combinations control neuronal identity through a network of temporal regulators.
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