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Joseph Buxbaum

@jdbux.bsky.social
253 followers 444 following 114 posts

Director, Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai. Shakuhachi student.

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Joseph Buxbaum @jdbux.bsky.social · 28/09/2026
One of the most exciting findings from the recent ASC papers is one that suggests a genetic mechanism that can explain the male bias of autism. I wrote a summary of the study on Linkedin. www.linkedin.com/pulse/what-e...
linkedin.com
What explains the male bias in autism?
Here are a few of the theories proposed to explain the male bias in autism, some with more evidence than others. However, it is fair to say that none of these theories, or combinations of them, clearl...
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Joseph Buxbaum @jdbux.bsky.social · 27/09/2026
With the completion of the most recent Autism Sequencing Consortium (ASC) data freeze, the ASC and collaborator sites have submitted six linked papers, with additional manuscripts expected within six months. For links to the manuscripts with brief summaries go to: www.linkedin.com/pulse/six-ne...
linkedin.com
Six new manuscripts from the Autism Sequencing Consortium
With the completion of the most recent Autism Sequencing Consortium (ASC) data freeze, the ASC and collaborator sites have submitted several linked papers, with additional manuscripts expected within ...
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The Daily Show @thedailyshow.com · 25/09/2026
"Please ban us!" Journalists beg White House to ban them from covering JD Vance
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Jeremy Berg @jeremymberg.bsky.social · 18/09/2026
Today's installment in the NIH institute director shitshow... A new director for the National Institute for Dental and Craniofacial Research (NIDCR). www.nih.gov/news-events/... As far as I can tell, he has three publications and has never received NIH funding. 1/2
nih.gov
Dr. Jonathan Burke selected as director of the National Institute of Dental and Craniofacial Research
Dr. Burke will start his role on Sept. 20, 2026.
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Joseph Buxbaum @jdbux.bsky.social · 22/08/2026
White House Taps Mean Teen In Zara Fitting Room As New Press Secretary — theonion.com/white-house-...
theonion.com
White House Taps Mean Teen In Zara Fitting Room As New Press Secretary
WASHINGTON—Touting her overall cruelty and particular delight at making others feel miserably self-conscious, the White House on Monday tapped a mean teenager from a Zara fitting room as its new press...
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Joseph Buxbaum @jdbux.bsky.social · 21/08/2026
www.facebook.com/share/18iRzm...
facebook.com
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Joseph Buxbaum @jdbux.bsky.social · 20/08/2026
m.facebook.com/story.php?st... Four more hours to comment.
m.facebook.com
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turrigiano.bsky.social @turrigiano.bsky.social · 02/08/2026
Some good news! Not a done deal, but important step. If you wondered if submitting your comments on the OMB rules change mattered, the answer is a resounding YES
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Princess Vimentin PhD | Cancer Biologist @princess-vimentin.bsky.social · 02/08/2026
Yaaas! Good news on a Sunday! The senate moves to temporarily ban the OMB proposal that would allow political appointees in charge of approving federal grants, especially #NIH grants. Recall that the OMB rule yielded 500k comments, 95% of them against it. 🧪 www.politico.com/news/2026/08...
politico.com
Senate finalizes funding patch that would block Trump’s grant overhaul
Language is included to delay the president’s move to put political appointees in charge of grant approval.
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Cole Donovan @colesci.bsky.social · 02/08/2026
This is an outstanding result, but we’re not done yet! The NSF update is still open for comment and not directly impacted. Keep the pressure up! fight2win.standupforscience.net
fight2win.standupforscience.net
Stand up for Science
Stand up for Science
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Prof Peter Hotez MD PhD DSc(hon) @peterhotezmdphd.bsky.social · 03/08/2026
Qing
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Prof Peter Hotez MD PhD DSc(hon) @peterhotezmdphd.bsky.social · 02/08/2026
CNN 1
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Prof Peter Hotez MD PhD DSc(hon) @peterhotezmdphd.bsky.social · 03/08/2026
#ScienceUnderSiege @publicaffairs1796.bsky.social @michaelemann.bsky.social @peterhotezmdphd.bsky.social
Science Under Siege
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Prof Peter Hotez MD PhD DSc(hon) @peterhotezmdphd.bsky.social · 03/08/2026
medicine.yale.edu/news-article...
Lyme
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Prof Peter Hotez MD PhD DSc(hon) @peterhotezmdphd.bsky.social · 03/08/2026
Science Under Siege
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Prof Peter Hotez MD PhD DSc(hon) @peterhotezmdphd.bsky.social · 03/08/2026
More BS
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Joseph Buxbaum @jdbux.bsky.social · 29/07/2026
apnews.com/article/roos...
apnews.com
Giant metal roosters spread autism acceptance in Maine after town zoning spat
Giant metal roosters are popping up on lawns in and around a coastal Maine community and as far away as New Zealand in support of a 6-year-old autistic girl and her love of the colorful creations.
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Joseph Buxbaum @jdbux.bsky.social · 06/07/2026
www.facebook.com/share/v/1E9m...
facebook.com
Facebook
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Lauren Dobson-Hughes @ldobsonhughes.bsky.social · 24/06/2026
Musk says not a single person has died due to him axing USAID. Sadly, part of my job involves tracking aid spending. So here’s a thread with just some of the people who lost their lives because of USAID cuts
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Joseph Buxbaum @jdbux.bsky.social · 20/06/2026
The Science That Turned Lizard Venom Into GLP-1s Is Under Attack www.nytimes.com/2026/06/20/o...
nytimes.com
Opinion | The Science That Turned Lizard Venom Into GLP-1s Is Under Attack
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Joseph Buxbaum @jdbux.bsky.social · 19/06/2026
Large-scale transcriptomic study reveals that eating disorders (ED) and OCD share common molecular substrate in the human brain. ED and OCD converge on cortico-striatal transcriptional programs. Downregulation links mitochondrial function and inhibitory synaptic signaling. doi.org/10.1016/j.ce...
doi.org
Redirecting
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Hannah Waters @hanner.bsky.social · 18/06/2026
My first art credit! 💅 Art director Samuel Velasco and I wanted a new visual metaphor for the genome — not a code or a sequence, but its tangled, twisted physical form. More cool yarn sculptures inside! Also it's a great piece by @philipcball.bsky.social that will change the way you think about DNA
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Quanta Magazine @quantamagazine.org · 18/06/2026
The human genome is no blueprint or algorithm — it’s something else entirely, something living with promiscuous logic. Can new genomic AI models, such as Evo 2 and AlphaGenome, untangle these tricky knots or will the genome confound them, too? www.quantamagazine.org/why-the-huma...
quantamagazine.org
Why the Human Genome’s Tangled Physicality May Confound AI | Quanta Magazine
Our genetic heritage is not a blueprint or an algorithm, as many biologists have imagined, but something else entirely.
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AAUP @aaup.org · 16/06/2026
Yet another disastrous move for public education: Shifting the Office for Civil Rights to the DOJ will strip marginalized students of vital protections leaving them more exposed to systemic discrimination, unsurprisingly subverting the core mission of the Office for Civil Rights. #AcademicSky
npr.org
Trump further guts Education Dept. by shifting oversight of special ed, civil rights
The moves to the federal departments of Health and Human Services and Justice, respectively, would further dismantle an agency that President Donald Trump has vowed to close.
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AFT @aft.org · 16/06/2026
📢 The Department of Education is shifting key special education and civil rights responsibilities to other agencies. AFT President @rweingarten.bsky.social responded, calling the move “a dagger to the heart” of the department’s mission to protect the most vulnerable. Read her statement ⤵️
aft.org
AFT’s Weingarten on Education Department’s Move of Special Ed and Civil Rights Offices to Other Agencies
WASHINGTON—AFT President Randi Weingarten issued the following statement after the federal Department of Education announced it was moving two of its most crucial functions to the Department of Health...
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European Society of Human Genetics @eshg.bsky.social · 13/06/2026
Attend the Leena Peltonen Award lecture now at #eshg2026 with Nicola Whiffin from Oxford University and learn About her recent discovieries in rare diseases and the broader inclusion of non-coding variants in clinical genetic testing that led to the Leena Peltonen Award. Congratulations!
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turrigiano.bsky.social @turrigiano.bsky.social · 29/05/2026
new kick in the teeth for US science. These are PROPOSED new rules that just dropped in the federal register. TLDR: would effectively allow political appointees to direct the $ where ever they want. Comments open until July 13.
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𝔸𝕞𝕓𝕖𝕣 𝔻𝕒𝕨𝕟 @amberdawn1116.bsky.social · 12/05/2026
“Could you fucking NOT?!”
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Joseph Buxbaum @jdbux.bsky.social · 07/05/2026
www.npr.org/2026/05/05/n...
npr.org
The Trump administration is finding new ways to withhold federal funding for science
Billions in funding were cut under President Trump were restored in 2026. Now, watchdogs say the administration is finding other ways to withhold money – and scientists are feeling the consequences.
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Joseph Buxbaum @jdbux.bsky.social · 29/04/2026
www.nature.com/articles/d41...
nature.com
Key US science panels are being axed — and others are becoming less open
A Nature analysis shows that the Trump administration has terminated more than 100 advisory committees to science agencies — and reduced the transparency and independence of those that remain.
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Joseph Buxbaum @jdbux.bsky.social · 31/03/2026
an amazing collaboration that identified a completely new pathway in Down syndrome - bioengineer.org/researchers-...
bioengineer.org
Researchers Link RNA Editing Dysregulation to Abnormal Fetal Brain
A groundbreaking collaborative effort led by researchers from the Icahn School of Medicine at Mount Sinai and the Lieber Institute for Brain Development has unveiled a previously unknown biological
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Joseph Buxbaum @jdbux.bsky.social · 30/03/2026
An amazing and inspiring collaboration across the Americas shows that the genetic architecture of autism is consistent across diverse ancestral populations. urldefense.proofpoint.com/v2/url?u=htt...
urldefense.proofpoint.com
Deleterious coding variation associated with autism is shared across ancestries
Nature Medicine - Genetic analyses in more than 15,000 individuals from across the Americas, including individuals with autism and family members, define the genetic landscape of autism in Latin...
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Debby Silver @debbysilver.bsky.social · 19/03/2026
Delighted to share that our study is now out @cp-cellstemcell.bsky.social www.cell.com/cell-stem-ce... Congrats to Dr. @federicamosti.bsky.social for the culmination of a beautiful thesis!
cell.com
Species-specific chromatin architecture and neurogenesis mediated by a human enhancer
How human-specific DNA changes shape brain development is poorly understood. Mosti et al. discover a human enhancer, HAR1984, which drives ETV5 and TRA2B expression via human-enriched chromatin intera...
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Joseph Buxbaum @jdbux.bsky.social · 16/03/2026
Judge Strikes Down Kennedy’s Vaccine Policies www.nytimes.com/2026/03/16/h...
nytimes.com
Judge Strikes Down Kennedy’s Vaccine Policies
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Joseph Buxbaum @jdbux.bsky.social · 10/03/2026
How Congress can restore the independence of US science www.nature.com/articles/d41...
nature.com
How Congress can restore the independence of US science
Members must go beyond reinstating US government research spending and re-establish decentralized governance at the National Institutes of Health and other agencies.
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Joseph Buxbaum @jdbux.bsky.social · 09/03/2026
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Joseph Buxbaum @jdbux.bsky.social · 28/02/2026
www.fda.gov/news-events/...
fda.gov
FDA Launches Framework for Accelerating Development of Individualized Therapies for Ultra-Rare Diseases
The U.S. Food and Drug Administration today issued draft guidance for sponsors seeking approval for targeted individualized therapies by generating substantial evidence of effectiveness and safety whe...
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Joseph Buxbaum @jdbux.bsky.social · 25/02/2026
sparkns.org/news-and-ins... what an amazing opportunity!!
sparkns.org
Nine Principal Investigators Join the SPARK NS Program, 2026 Cohort
The nine projects are collectively eligible for up to $18 million in funding and support for drug development.
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Joseph Buxbaum @jdbux.bsky.social · 21/02/2026
www.rollingstone.com/politics/pol...
rollingstone.com
New Documents Reveal a Controversial Vaccine Study's Unusual Path to CDC Approval
A new investigation has found irregularities in the ethics review of a grant to study effects of a birth dose of hepatitis B vaccine in Guinea-Bissau.
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Elizabeth Jacobs, PhD @elizabethjacobs.bsky.social · 21/02/2026
A lot of people, including me, were wondering how an IRB could ever approve this study. The answer is that no IRB did. The person who “signed off” on approval from the only ethics board that reviewed it had resigned three years earlier. His signature was used without his knowledge.
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Popehat @kenwhite.bsky.social · 09/02/2026
Your Ring camera can scam passing dogs and compare them to databases of missing dogs and that’s heartwarming and there are absolutely no sinister implications that’s why the guy in the button-down and Dockers is soothing
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Joseph Buxbaum @jdbux.bsky.social · 09/02/2026
A good moment to remember all that Paul Allen did for science and for Seattle and for the Seahawks !!! www.science.org/doi/10.1126/...
science.org
Paul G. Allen (1953–2018)
Cofounder of Microsoft, visionary, and philanthropist
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Joseph Buxbaum @jdbux.bsky.social · 12/01/2026
www.ncronline.org/opinion/ncr-...
ncronline.org
Catholic Vice President Vance takes to social media to justify killing of Renee Good
After the tragic shooting of Renee Good at the hands of ICE, the Catholic vice president of the United States took to social media to justify the killing.
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Science Magazine @science.org · 30/12/2025
President Donald Trump’s administration has declined to reappoint Walter Koroshetz as head of the NIH’s neuroscience institute—even though the agency’s director had backed his renewal. scim.ag/4pZD0kq
scim.ag
Firing of neuroscience institute chief adds to NIH’s leadership vacuum
Trump administration declines to renew appointment of Walter Koroshetz, against NIH director’s wishes
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Alt National Park Service @altnps.bsky.social · 28/12/2025
Peter Thiel says he’ll leave California if they pass a 1% wealth tax on billionaires for five years. So… how much would it take to make him leave the U.S.?
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Joseph Buxbaum @jdbux.bsky.social · 02/12/2025
www.nytimes.com/interactive/... 43% fewer grants funded in mental health, 47% fewer grants funded in human genomics/genetics research, and 61% fewer grants funded in minority health.
nytimes.com
The U.S. Is Funding Fewer Grants in Every Area of Science and Medicine
A quiet policy change means the government is making fewer bets on long-term science.
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Joseph Buxbaum @jdbux.bsky.social · 20/11/2025
autismsciencefoundation.org/press_releas...
autismsciencefoundation.org
CDC’s New Autism Webpage Distorts Science and Rejects Decades of Evidence on Vaccine Safety - Autism Science Foundation
NEW YORK, NY (November 20, 2025) We are appalled to find that the content on the CDC webpage “Autism and Vaccines” has been changed and distorted, and is now filled with anti-vaccine rhetoric and outr...
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Joseph Buxbaum @jdbux.bsky.social · 20/11/2025
www.reuters.com/business/hea...
reuters.com
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Joseph Buxbaum @jdbux.bsky.social · 15/11/2025
www.theepochtimes.com/health/how-g...
theepochtimes.com
Autism Has 2 Main Genetic Drivers–How Treatments Can Help
Three children, one major genetic difference, three different outcomes.
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