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Joshua Weinstein

@jaweinst.bsky.social

wlab.bio

Joshua Weinstein @jaweinst.bsky.social · 04/06/2026

Delighted to share our new preprint on xVDM (cross-linked volumetric DNA microscopy), turning the protein scaffolds inside intact tissue into dense, DNA-encoded proximity networks for transcriptome and protein mapping. www.biorxiv.org/content/10.6...

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Reposted by Joshua Weinstein

Nature Protocols @natprot.nature.com · 25/02/2026

New Article! Volumetric DNA microscopy for mapping spatial transcriptomes in three dimensions

dlvr.it

Volumetric DNA microscopy for mapping spatial transcriptomes in three dimensions

Nature Protocols, Published online: 24 February 2026; doi:10.1038/s41596-025-01329-3This protocol for encoding spatial information via DNA sequences enables template-free reconstruction of three-dimensional gene expression patterns in intact specimens, thereby overcoming the limitations of two-dimensional spatial imaging.

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Reposted by Joshua Weinstein

Nature Biotechnology @natbiotech.nature.com · 24/02/2026

Volumetric DNA microscopy captures spatial information of RNA within an intact organism go.nature.com/42hJ1Q2 rdcu.be/e5kML

go.nature.com

Spatial transcriptomic imaging of an intact organism using volumetric DNA microscopy - Nature Biotechnology

Volumetric DNA microscopy captures spatial information of RNA within an intact organism.

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Joshua Weinstein @jaweinst.bsky.social · 27/03/2025

1. Finer detail – not quite at organism-wide cellular resolution yet, but we’re getting there. 2. Benchmarking gene-enrichments across the organism using spatial array-based datasets. 3. Further development of GSE for embedding 10^7 points/UMIs with research-grade compute.

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Joshua Weinstein @jaweinst.bsky.social · 27/03/2025

The paper builds on our earlier preprint: doi.org/10.1101/2023... What’s new (highlights):

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Joshua Weinstein @jaweinst.bsky.social · 27/03/2025

Delighted to share our new paper on 3D imaging of an intact organism via a distributed molecular network, now out in Nature Biotechnology: doi.org/10.1038/s415... www.nature.com/articles/s41...

doi.org

Spatial transcriptomic imaging of an intact organism using volumetric DNA microscopy - Nature Biotechnology

Volumetric DNA microscopy captures spatial information of RNA within an intact organism.

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