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Janelia GENIE

@janeliagenie.bsky.social

The Genetically-ENcoded Indicator and Effector (GENIE) project at the Janelia Research Campus of HHMI has the organization, multidisciplinary know-how, and technology to greatly accelerate optimization of protein sensors for observing biological function.

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Janelia GENIE @janeliagenie.bsky.social · 29/07/2025

🧠🪰 New from GENIE @HHMIJanelia: far-red #RubyACRs from the Spudich Lab enable robust optogenetic inhibition in freely behaving #Drosophila — validated with ephys, imaging & behavior. 📄 Paper bit.ly/3H7S7af 🪰 Get flies bit.ly/41iVNwK med.uth.edu/bmb/spudich/ #OptoInhibition #FlyNeuro #FlyOptogenetics

Activation of RubyACRs in the pIP10 neuron suppressed pulse song of male flies during courtship.

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Janelia GENIE @janeliagenie.bsky.social · 27/03/2025

Improved genetically-encoded GABA indicator are now published. iGABASnFR2 has 4.2X better sensitivity and 20% faster kinetics; detects direction selective GABA release in the retina 📃Preprint: bit.ly/4hISy7b 🧪Plasmids & AAVs: bit.ly/3FDh8Jl @addgene.bsky.social @hhmijanelia.bsky.social #Neuroscience

Fluorescence images of primary neurons expressing iGABASnFR variants at peak brightness after field stimulation with 40 APs

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