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Adaptive potential determines how populations respond to environmental change. This study compiles evolvability estimates from over 170 multicellular species, revealing substantial variation across th...

Aging has effects on the immune system that are similar in men and women, but also reshapes their immune systems in unique, sex-specific ways, however these differences are rarely taken into…

Una investigación publicada en Nature Medicine aporta un dato sorprendente: los efectos pueden prolongarse hasta 8 años

Here, the authors show that strategies to restore host–microbiota symbiosis by preserving butyrate levels delay multimorbidity and extend lifespan in mice with mitochondrial dysfunction, in associatio...

The new OLGIMA method for histological gastric cancer risk assessment is based on the severity of glandular atrophy and intestinal metaplasia, in both antrum and corpus, according to the Updated Sydn...

Optogenetic stimulation enables direct and selective stimulation of smooth muscle cells and thus provides a new opportunity to restore gastric contractility in cases of gastroparesis. Herein, we demo...

In a prospective study involving 92 physicians from multiple institutions, access to large language model assistance on top of conventional resources increased a score expressing the quality of their ...

Several factors make small bowel bleeding (SBB) increasingly common in clinical practice. Medical advances have extended the lives of patients with advanced comorbidities including chronic kidney dise...

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Irritable bowel syndrome (IBS) is a common disorder of gut–brain interaction characterised by symptoms of abdominal pain, occurring at least 1 day per week, and a change in stool frequency or form. Individuals with IBS are usually subtyped according to their predominant bowel habit, which is used to direct symptom-based treatment. However, this approach is probably an oversimplification of a complex and multidimensional condition, and other factors, such as psychological health, are known to influence symptom severity and prognosis.

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Accurate reporting of polyp characteristics is crucial for effective resource allocation in endoscopic resection referrals. We present our experience with pre-referral management of challenging colore...

Abstract. Inflammatory bowel disease [IBD] patients are at increased risk of developing colorectal neoplasia [CRN]. In this review, we aim to provide an up

Visceral pain is a major clinical issue, most commonly associated with gastrointestinal disorders. This Review discusses molecular mechanisms by which neurons are sensitized in the gut, outlining sign...

HLADQA1*05 is associated with a higher risk of LOR and immunogenicity, particularly to infliximab. HLADQA1*03 seems to play a protective role against LOR, particularly to adalimumab. Female sex and in...